Comparison of the BD Viper System With XTR Technology to the Gen-Probe APTIMA COMBO 2 Assay Using the TIGRIS DTS System for the Detection of Chlamydia trachomatis and Neisseria gonorrhoeae in Urine Specimens

Abstract

There was a high level of agreement between the systems for both CT and GC detection.

Workflow and Maintenance Characteristics of Five Automated Laboratory Instruments for the Diagnosis of Sexually Transmitted Infections

“…With clearance by the U.S. Food and Drug Administration and other regulatory agencies in Europe and elsewhere of several systems, automated molecular testing has become routine in clinical laboratory practice, ensuring diagnostic accuracy and improved result turnaround time (TAT). Studies have been published assessing clinical performances of molecular assays (2)(3)(4)(5)(6)(7)(8), and workflow and maintenance characteristics of automated instruments (9)(10)(11)(12)(13)(14)(15)(16). In addition to performance and instrumentreagent costs, hands-on time required for testing and maintenance, in-process interaction, and time to results and test capacity are key metrics that should be considered because they can influence efficiency and labor costs.…”

The performance of non-NAAT point-of-care (POC) tests and rapid NAAT tests for chlamydia and gonorrhoea infections. An assessment of currently available assays

“…Other gonorrhoea assays reviewed and not used in the modelling were Biostar (OIA)8 and NOW 23. The NOW data was excluded as the patients in the published paper were highly selected.…”

Emerging Technologies for the Clinical Microbiology Laboratory

“…This enables more rapid, accurate identification of the pathogen(s) responsible for nonspecific symptoms of urethritis or pelvic inflammatory disease and also may aid in limiting the spread of these organisms by identifying asymptomatic carriers. Additionally, the increased sensitivity of NAATs can enable the analysis of specimens obtained by less invasive techniques or of patient-collected specimens, including urine and self-collected vaginal swabs, without affecting the accuracy of the test (12,13,(17)(18)(19). The ability to use these types of specimens can contribute to higher participation in routine screening exams (12,13,(17)(18)(19).…”

“…Additionally, the increased sensitivity of NAATs can enable the analysis of specimens obtained by less invasive techniques or of patient-collected specimens, including urine and self-collected vaginal swabs, without affecting the accuracy of the test (12,13,(17)(18)(19). The ability to use these types of specimens can contribute to higher participation in routine screening exams (12,13,(17)(18)(19). Other pathogens commonly identified using qualitative NAATs include respiratory viruses, herpesviruses, Clostridium difficile, Staphylococcus aureus, methicillin-resistant S. aureus (MRSA), Streptococcus pyogenes, Streptococcus agalactiae, Bordetella pertussis, and bacterial pathogens associated with atypical pneumonia.…”