Comparison of the antimicrobial and antioxidant activities of tea tree (Melaleuca alternifolia) oil and its main component terpinen-4-ol with their nanoemulsions

Badr, Mai M.; Taktak, Nehad E. M.; Badawy, Mohamed E. I.

doi:10.21608/ejchem.2022.131758.5808

Cited by 6 publications

(3 citation statements)

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“…Additionally, Brun et al found that TTO products exhibited inhibition against antibiotic-resistant S. aureus and Pseudomonas aeruginosa [25]. The antimicrobial effect exhibited by TTO may be assigned to terpinen-4-ol, which is the primary constituent of TTO [26,27]. The terpinen-4-ol constituent causes cell death by irreversibly destroying the microbial membrane and inducing the loss of cytoplasm, as reported previously [28].…”

Section: Discussionmentioning

confidence: 70%

The Biological Activity of Tea Tree Oil and Hemp Seed Oil

Lakatos

Apori

Dunne

et al. 2022

Applied Microbiology

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The interest in hemp seed oil (HSO) and tea tree oil (TTO) in the medical and food industries is increasing. The current study compares their bioactivity to other plant oils, mainly focusing on hemp seed oils (HSOs) with various cannabidiol (CBD) contents. A DPPH assay was employed to evaluate the antioxidant activity. The antimicrobial activity against Escherichia coli, Staphylococcus aureus, and Salmonella enteritidis was evaluated using time–kill, minimum inhibition concentration (MIC), and Kirby–Bauer disk diffusion methods. Tea tree oil showed significantly higher antimicrobial activity against S. enteritidis compared to E. coli and S. aureus (p < 0.05). The antioxitant activity range (lowest to highest) was sesame < vetiver < rosehip < tea tree < organic hemp < pure hemp < 5% CBD < vitamin C. Tea tree oil and 5% CBD showed antioxidant activity at IC50 of 64.45 μg/mL and 11.21 μg/mL, respectively. The opposing antimicrobial and antioxidant results for TTO and HSO indicate that these activities arise from different components within the oil compositions.

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Section: Discussionmentioning

confidence: 70%

The Biological Activity of Tea Tree Oil and Hemp Seed Oil

Lakatos

Apori

Dunne

et al. 2022

Applied Microbiology

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“…D-Limonene is a monocyclic monoterpene with remarkable antioxidant activity in ABTS (IC 50 � 603.23 µM) and DPPH (IC 50 � 384.73 µM) [46]. According to past reports, β-caryophyllene [47], nerolidol [48], α-pinene [43], caryophyllene oxide [40], α-phellandrene [49], p-cymene [50], terpinen-4-ol [51], and α-terpineol [52] exhibited antioxidant efects. Te moderate antioxidant ability of H. favum L-EO and S-EO may be related to these major components.…”

Section: Antioxidant Activity Antioxidant Activities Of H Favummentioning

confidence: 99%

Exploring the Composition and Bioactivity of Hedychium flavum Leaf and Stem Essential Oil: In Vitro Assessment of Antibacterial, Antioxidant, Cytotoxicity, and Enzyme Inhibitory Activities

Ding,

Wu,

Yang

et al. 2024

Journal of Chemistry

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Hedychium flavum is an edible, medicinal, and aromatic plant widely cultivated for its essential oil. So far, little studies have been done on its phytoconstituents and bioactivities. Hence, the research aimed to determine the chemical constituents of leaf essential oil (L-EO) and stem essential oil (S-EO) of H. flavum and first estimate their antibacterial, antioxidant, cytotoxic, and enzyme inhibitory activities. According to gas chromatography-flame ionization detector/mass spectrometer (GC-FID/MS) assay, L-EO was mainly composed of β-pinene (33.4%), α-pinene (10.4%), humulene (6.8%), β-caryophyllene (6.0%), eucalyptol (6.0%), caryophyllene oxide (5.5%), endo-borneol (3.8%), humulene epoxide II (3.7%), and D-limonene (3.2%). The predominant components of S-EO were β-pinene (17.2%), eucalyptol (9.7%), nerolidol (7.8%), α-phellandrene (6.7%), α-pinene (5.8%), β-caryophyllene (5.4%), terpinen-4-ol (4.5%), D-limonene (4.4%), p-cymene (3.7%), endo-borneol (3.5%), and α-terpineol (3.5%). For the bioactivities, L-EO and S-EO showed strong antibacterial activity against Escherichia coli, Enterococcus faecalis, and Bacillus subtilis with the minimum inhibitory concentration (MIC) of 9.77–625.00 µg/mL and the minimum bactericidal concentration (MBC) of 9.77–1250.00 µg/mL. Both L-EO and S-EO exhibited moderate antioxidant activity in the DPPH (14.52 ± 0.93 mg/mL and 4.73 ± 0.15 mg/mL, respectively) and ABTS (4.05 ± 0.75 mg/mL and 2.38 ± 0.14 mg/mL, respectively) free radical scavenging capacity. S-EO showed selective cytotoxicity on human leukemic K562 cell line (IC50 = 93.94 ± 0.91 µg/mL), which was nearly three times that of noncancer L929 cell line (IC50 = 294.49 ± 9.40 µg/mL). In enzyme inhibitory properties, L-EO exerted a potent inhibition on α-glucosidase (IC50 = 1.03 ± 0.02 mg/mL), and both essential oils had weak inhibition against cholinesterase and tyrosinase. Thus, H. flavum L-EO and S-EO possess antibacterial, antioxidant, cytotoxic, and enzyme inhibitory activities with potential for exploitation in the food, cosmetic, and pharmaceutical industries.

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“…Consequently, T-4-ol was proposed as a potent antioxidant that overcomes the toxicities and side effects exerted by the administration of conventional drugs used for resolving rheumatoid arthritis [47]. Furthermore, Badr et al prepared separate nanoformulations of TTO and T-4-ol and scrutinized their radical-scavenging activities in terms of EC50 values (effective drug concentration that inhibited radical scavenging by 50%) [48]. The findings revealed that T-4-ol nanoemulsions possessed 7.72-fold higher DPPH-scavenging potential (EC50 = 253.65 mg/L) as compared to TTO nanoemulsions (EC50 = 1952.82 mg/L).…”

Section: Antioxidant Activity Of T-4-ol: On the Hunt For Radical Scav...mentioning

confidence: 99%

A Comprehensive Review on the Pharmacological Prospects of Terpinen-4-Ol: From Nature to Medicine and Beyond

Prerna,

Chadha,

Khullar

et al. 2024

Preprint

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Owing to their extensive biological potential, essential oils (EOs) and their bioactive phytochemicals have gained attention from the scientific community. Within this domain, Terpinen-4-ol (T-4-ol), a bioactive monoterpene alcohol and the major constituent of tea tree oil (TTO), has made its way into translational research. Recent literature on T-4-ol strongly indicates its diverse pharmacological properties, including but not limited to antimicrobial, antivirulent, antioxidant, anti-inflammatory, anti-hypertensive, and anti-cancer effects. Hence, this review provides a comprehensive overview of the multifaceted biological activities exhibited by T-4-ol, emphasizing its medicinal potential for widescale application. The antibacterial and antifungal effectiveness of T-4-ol has been discussed encompassing its role in combating a broad spectrum of bacterial and fungal pathogens, respectively. The review delves into the antivirulent prospects of T-4-ol, shedding light on its ability to attenuate virulence and mitigate bacterial pathogenesis. Scientific literature on the antioxidant and anti-inflammatory activity of T-4-ol highlighting its role in neutralizing reactive oxygen species and modulating inflammatory pathways has also been collated. Furthermore, the review elaborates on the cardioprotective and anti-hypertensive properties of T-4-ol and augments literature on its anti-cancer mechanism against various cancer cell lines. Overall, this review consolidates the existing knowledge on T-4-ol, providing a holistic understanding of its pharmacological abilities. The exploration of these diverse attributes positions T-4-ol as a promising candidate for further research and therapeutic repurposing in various biomedical applications.

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Comparison of the antimicrobial and antioxidant activities of tea tree (Melaleuca alternifolia) oil and its main component terpinen-4-ol with their nanoemulsions

Cited by 6 publications

References 0 publications

The Biological Activity of Tea Tree Oil and Hemp Seed Oil

The Biological Activity of Tea Tree Oil and Hemp Seed Oil

Exploring the Composition and Bioactivity of Hedychium flavum Leaf and Stem Essential Oil: In Vitro Assessment of Antibacterial, Antioxidant, Cytotoxicity, and Enzyme Inhibitory Activities

A Comprehensive Review on the Pharmacological Prospects of Terpinen-4-Ol: From Nature to Medicine and Beyond

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