Comparison of the antidepressant sertraline on differential depression-like behaviors elicited by restraint stress and repeated corticosterone administration

Ulloa, José Luis; Castañeda, Patricia; Berríos, Camilo; Dı́az-Véliz, Gabriela; Mora, Sergio; Bravo, Javier A.; Araneda, Karina; Menares, Camilo; Morales, Paola; Fiedler, Jenny L.

doi:10.1016/j.pbb.2010.08.001

Cited by 57 publications

(45 citation statements)

References 65 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In addition, the hippocampus participates in the intersection between cognition and emotion and plays a crucial in the pathophysiology of mood disorders (Campbell and Macqueen, 2004; Femenía et al, 2012). Similar to other studies (Bondi et al, 2008), we previously reported that chronic stress in rodents produces anhedonia, impairs associative learning, and increases immobility in the forced swimming test (FST) (Bravo et al, 2009; Ulloa et al, 2010; Castaneda et al, 2015). Notably, these behavioral modifications are accompanied by dendritic atrophy and spine density reduction of pyramidal neurons in the hippocampus and prefrontal cortex (McEwen and Seeman, 1999; Vyas et al, 2002; Fernandez-Guasti et al, 2012; Castaneda et al, 2015).…”

Section: Introductionsupporting

confidence: 84%

The ROCK Inhibitor Fasudil Prevents Chronic Restraint Stress-Induced Depressive-Like Behaviors and Dendritic Spine Loss in Rat Hippocampus

García-Rojo

Fresno

Vilches

et al. 2016

IJNPPY

View full text Add to dashboard Cite

Background:Dendritic arbor simplification and dendritic spine loss in the hippocampus, a limbic structure implicated in mood disorders, are assumed to contribute to symptoms of depression. These morphological changes imply modifications in dendritic cytoskeleton. Rho GTPases are regulators of actin dynamics through their effector Rho kinase. We have reported that chronic stress promotes depressive-like behaviors in rats along with dendritic spine loss in apical dendrites of hippocampal pyramidal neurons, changes associated with Rho kinase activation. The present study proposes that the Rho kinase inhibitor Fasudil may prevent the stress-induced behavior and dendritic spine loss.Methods:Adult male Sprague-Dawley rats were injected with saline or Fasudil (i.p., 10 mg/kg) starting 4 days prior to and maintained during the restraint stress procedure (2.5 h/d for 14 days). Nonstressed control animals were injected with saline or Fasudil for 18 days. At 24 hours after treatment, forced swimming test, Golgi-staining, and immuno-western blot were performed.Results:Fasudil prevented stress-induced immobility observed in the forced swimming test. On the other hand, Fasudil-treated control animals showed behavioral patterns similar to those of saline-treated controls. Furthermore, we observed that stress induced an increase in the phosphorylation of MYPT1 in the hippocampus, an exclusive target of Rho kinase. This change was accompanied by dendritic spine loss of apical dendrites of pyramidal hippocampal neurons. Interestingly, increased pMYPT1 levels and spine loss were both prevented by Fasudil administration.Conclusion:Our findings suggest that Fasudil may prevent the development of abnormal behavior and spine loss induced by chronic stress by blocking Rho kinase activity.

show abstract

Section: Introductionsupporting

confidence: 84%

The ROCK Inhibitor Fasudil Prevents Chronic Restraint Stress-Induced Depressive-Like Behaviors and Dendritic Spine Loss in Rat Hippocampus

García-Rojo

Fresno

Vilches

et al. 2016

IJNPPY

View full text Add to dashboard Cite

show abstract

“…The behavioral tests measuring emotionality, anxiety, learning, and memory also reveal the well-established effects of CRS. We find a lack of effect of stress (or lineage) in the FS test (36,41). CRS has a profound effect on the structure and function of the hippocampus (42), and, with a single exception in the CRTX, differential expression of apoptosis genes of >1.2 is restricted to the CA1 and CA3 (Fig.…”

Section: Discussionmentioning

confidence: 74%

“…We also replicate the finding that this transgenerational epigenetic modification influences how individuals respond to events in their own life history (4,22) as well as the work of others that CRS experience influences an individual's physiological and behavioral phenotypes as an adult. CRS has an immediate and long-lasting effect on BW that correlates with CORT secretion later in life (35)(36)(37)(38) as well as a negative relationship between stress and CORT and TESTO (39,40). The behavioral tests measuring emotionality, anxiety, learning, and memory also reveal the well-established effects of CRS.…”

Section: Discussionmentioning

confidence: 99%

Epigenetic transgenerational inheritance of altered stress responses

Crews

Gillette

Scarpino

et al. 2012

Proc. Natl. Acad. Sci. U.S.A.

290

206

View full text Add to dashboard Cite

Ancestral environmental exposures have previously been shown to promote epigenetic transgenerational inheritance and influence all aspects of an individual's life history. In addition, proximate life events such as chronic stress have documented effects on the development of physiological, neural, and behavioral phenotypes in adulthood. We used a systems biology approach to investigate in male rats the interaction of the ancestral modifications carried transgenerationally in the germ line and the proximate modifications involving chronic restraint stress during adolescence. We find that a single exposure to a common-use fungicide (vinclozolin) three generations removed alters the physiology, behavior, metabolic activity, and transcriptome in discrete brain nuclei in descendant males, causing them to respond differently to chronic restraint stress. This alteration of baseline brain development promotes a change in neural genomic activity that correlates with changes in physiology and behavior, revealing the interaction of genetics, environment, and epigenetic transgenerational inheritance in the shaping of the adult phenotype. This is an important demonstration in an animal that ancestral exposure to an environmental compound modifies how descendants of these progenitor individuals perceive and respond to a stress challenge experienced during their own life history.

show abstract

“…Repeated restraint stress is an inescapable paradigm similar to LH where the animal is enclosed daily in a narrow tube (1–6h/day) for up to 21 consecutive days (Watanabe et al, 1992, Magarinos and McEwen, 1995, Kim and Han, 2006, Ulloa et al, 2010, Yu et al, 2012, Lee et al, 2013, Voorhees et al, 2013, Cheng et al, 2014). Adult rodents exposed to repeated restraint stress exhibit a depression-like phenotype marked by reduced sucrose preference, anxiety-like exploratory deficits and increased immobility in the forced swim test (Kim and Han, 2006, Ulloa et al, 2010, Lee et al, 2013, Voorhees et al, 2013), Some of these phenotypes can only be reversed by chronic treatments with antidepressants (Stone et al, 1984, Ulloa et al, 2010, Yu et al, 2012).…”

Section: Animal Models Of Depressionmentioning

confidence: 99%

“…Adult rodents exposed to repeated restraint stress exhibit a depression-like phenotype marked by reduced sucrose preference, anxiety-like exploratory deficits and increased immobility in the forced swim test (Kim and Han, 2006, Ulloa et al, 2010, Lee et al, 2013, Voorhees et al, 2013), Some of these phenotypes can only be reversed by chronic treatments with antidepressants (Stone et al, 1984, Ulloa et al, 2010, Yu et al, 2012). Stress-related hormones, notably corticosterone, initially increase following restraint stress (Magarinos and McEwen, 1995, Kim and Han, 2006, Lee et al, 2013, Voorhees et al, 2013).…”

Section: Animal Models Of Depressionmentioning

confidence: 99%

Pathogenesis of depression: Insights from human and rodent studies

2016

View full text Add to dashboard Cite

Major depressive disorder (MDD) will affect one out of every five people in their lifetime and is the leading cause of disability worldwide. Nevertheless, mechanisms associated with the pathogenesis of MDD have yet to be completely understood and current treatments remain ineffective in a large subset of patients. In this review, we summarize the most recent discoveries and insights for which parallel findings have been obtained in human depressed subjects and rodent models of mood disorders in order to examine the potential etiology of depression. These mechanisms range from synaptic plasticity mechanisms to epigenetics and the immune system where there is strong evidence to support a functional role in the development of specific depression symptomology. Ultimately we conclude by discussing how novel therapeutic strategies targeting central and peripheral processes might ultimately aid in the development of effective new treatments for MDD and related stress disorders.

show abstract

Comparison of the antidepressant sertraline on differential depression-like behaviors elicited by restraint stress and repeated corticosterone administration

Cited by 57 publications

References 65 publications

The ROCK Inhibitor Fasudil Prevents Chronic Restraint Stress-Induced Depressive-Like Behaviors and Dendritic Spine Loss in Rat Hippocampus

The ROCK Inhibitor Fasudil Prevents Chronic Restraint Stress-Induced Depressive-Like Behaviors and Dendritic Spine Loss in Rat Hippocampus

Epigenetic transgenerational inheritance of altered stress responses

Pathogenesis of depression: Insights from human and rodent studies

Contact Info

Product

Resources

About