Comparison of the antiatherosclerotic effects of dihydropyridine calcium channel blocker and HMG-CoA reductase inhibitor on hypercholesterolemic rabbits

The Lectin-Like Oxidized Low-Density Lipoprotein Receptor-1 and its Soluble Form: Cardiovascular Implications

“…In the aorta of hypercholesterolemic rabbits, benidipine, a dihydropyridine-type calcium channel blocker, significantly prevented the up-regulation of VCAM-1 mRNA expression and tended to inhibit LOX-1 mRNA expression, while pravastatin significantly prevented the up-regulation of both VCAM-1 and LOX-1 mRNA expression 116) . Moreover, aspirin and salicylate (but not indomethacin) reduced oxLDL-mediated LOX-1 expression in a dose-and time-dependent fashion 117) .…”

Identification, synthesis and characterization of process related impurities of benidipine hydrochloride, stress-testing/stability studies and HPLC/UPLC method validations

“…It blocks three different types of calcium channels (L, N and T) in the cell membrane by its unique mechanism of action. Benidipine has different unique chemical properties compared to the other calcium channel blocker agents [2] , such as strong and long acting effect due to its high affinity and unique membrane binding sites, renal protective effect due to its triple (L, N and T) calcium channel blockage, and cardioprotective and vasoprotective effect due to its vascular selectivity and positive effect on nitric oxide production. As a solid, benidipine hydrochloride is stable to variations in heat and moisture, and is fairly stable to light exposure [3] .…”

Synthesis of Some New 1,2,3,4-Tetrahydropyrimidine-2-thione and Their Thiazolo[3,2-a]pyrimidine, Thiazino and Benzothiazepine Derivatives

“…In addition, the chemistry and the synthesis of 1,2,3,4‐tetrahydropyrimidine‐2‐thione have attracting wide spread attention in recent years. The present popularity of these tetrahydropyrimidines is mainly because of their close structural relationship to the clinically important dihydropyridine calcium‐channel blockers and related compounds . 1,2,3,4‐Tetrahydropyrimidine‐2‐thione is known as versatile heterocyclic compound that has been subjected to a large variety of structural modification in order to synthesized derivatives with different biological properties.…”