Comparison of the Adsorption of Several Drugs to Typical Filter Materials

Lindenberg, Marc; Wiegand, Cornelia; Dressman, Jennifer B.

doi:10.14227/dt120105p22

Cited by 33 publications

(18 citation statements)

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“…With respect to both chosen model drugs prednisolone and acetylsalicylic acid, the results indicate that the nylon/ polyamide material is unacceptable for dissolution testing. The high adsorption property of nylon has been reported by other authors (3,6). Therefore, other filter materials should be used for dissolution experiments.…”

Section: Discussionsupporting

confidence: 73%

Evaluation of Drug Adsorption to Membrane Filters under Biowaiver Test Conditions

Kiehm¹,

Dressman

2008

Dissolution Technol.

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Section: Discussionsupporting

confidence: 73%

Evaluation of Drug Adsorption to Membrane Filters under Biowaiver Test Conditions

Kiehm¹,

Dressman

2008

Dissolution Technol.

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“…BMZ adsorbed in filters was also verified using standard solutions (19). The HPLC method was used to analyze BMZ release in dissolution medium.…”

Section: Dissolution Methods Validationmentioning

confidence: 99%

Discriminative Dissolution Method for Benzoyl Metronidazole Oral Suspension

Silva

Paula

et al. 2015

AAPS PharmSciTech

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Abstract. A dissolution method for benzoyl metronidazole (BMZ) oral suspensions was developed and validated using a high-performance liquid chromatography (HPLC) method. After determination of sink conditions, dissolution profiles were evaluated using different dissolution media and agitation speeds. The sample insertion mode in dissolution media was also evaluated. The best conditions were obtained using a paddle, 50 rpm stirring speed, simulated gastric fluid (without pepsin) as the dissolution medium, and sample insertion by a syringe. These conditions were suitable for providing sink conditions and discriminatory power between different formulations. Through the tested conditions, the results can be considered specific, linear, precise, accurate, and robust. The dissolution profiles of five samples were compared using the similarity factor (f 2 ) and dissolution efficiency. The dissolution kinetics were evaluated and described by the Weibull model. Whereas there is no monograph for this pharmaceutical formulation, the dissolution method proposed can be considered suitable for quality control and dissolution profile comparison of different commercial formulations.

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“…For each formulation, the difference in the amount of fenofibrate dissolved after 60 min was 60%, 75%, and 60% for formulations A, B, and C, respectively (CA versus PTFE). The main reason for these results is probably that fenofibrate adsorbs differently to the two evaluated filters, which is a common problem discussed in other publications (20,21). Dressman and coworkers (20) have shown that another poorly water soluble drug, griseofulvin, dissolved in simulated intestinal fluid adsorbed to similar CA filters producing a recovery in the filtered samples of 73.7 ± 2.3% and 71.6 ± 3.6%, with and without discarding the first 2 mL of each sample, respectively.…”

Section: Paddle Dissolutionmentioning

confidence: 75%

“…Sample fractions were collected at predetermined intervals (5,10,15,20,25,30,45, 60 min). The equipment was fitted with 22.6-mm cells (internal diameter) and the temperature kept at 37.0 ± 0.5 °C.…”

Section: Usp 4: Flow-through Cell Apparatusmentioning

confidence: 99%

Dissolution Model Development: Formulation Effects and Filter Complications

Berthelsen¹,

Holm²,

Jacobsen³

et al. 2016

Dissolution Technol.

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This study describes various complications related to sample preparation (filtration) during development of a dissolution method intended to discriminate among different fenofibrate immediate-release formulations. Several dissolution apparatus and sample preparation techniques were tested. The flow-through cell apparatus (USP 4) was found unfit for dissolution testing of fenofibrate MeltDose formulations due to clogging of filters and varying flow rates. A mini paddle dissolution setup produced dissolution profiles of the tested formulations that correlated well with clinical data. The work towards the mini paddle dissolution method demonstrates that sample preparation influenced the results. The investigations show that excipients from the formulations directly affected the drug-filter interaction, thereby affecting the dissolution profiles and the ability to predict the in vivo data. With the tested drug-formulation combination, the best in vivo-in vitro correlation was found after filtration of the dissolution samples through 0.45-µm hydrophobic PTFE membrane filters.

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Comparison of the Adsorption of Several Drugs to Typical Filter Materials

Cited by 33 publications

References 0 publications

Evaluation of Drug Adsorption to Membrane Filters under Biowaiver Test Conditions

Evaluation of Drug Adsorption to Membrane Filters under Biowaiver Test Conditions

Discriminative Dissolution Method for Benzoyl Metronidazole Oral Suspension

Dissolution Model Development: Formulation Effects and Filter Complications

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