Comparison of the Adsorption Capacities of an Activated-Charcoal-Yogurt Mixture Versus Activated-Charcoal-Water Slurry In Vivo and In Vitro

Hoegberg, Lotte Christine Groth; Christophersen, Anne-Bolette; Christensen, Hanne; Angelo, Helle R.

doi:10.1081/clt-200066067

Cited by 13 publications

(15 citation statements)

References 7 publications

(15 reference statements)

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“…In this study, it is found that pH had no effect on the adsorption capacity. This is in accordance with other in vitro studies performed with paracetamol [9,10,[14][15][16].…”

Section: Discussionsupporting

confidence: 79%

“…Several in vitro studies investigate the adsorption capacity of different test substances to AC [9][10][11][13][14][15][16][17]. In this study, it is found that pH had no effect on the adsorption capacity.…”

Section: Discussionmentioning

confidence: 81%

“…So this study was performed at two different pHs (simulated gastric pH: 3.4 and simulated intestinal pH: 7.2) and the effect of pH on adsorption of paracetamol to AC was studied. Most of the previous in vitro studies [9][10][13][14][15][16] used the drugs in pure form. In this study the paracetamol was derived from tablets to simulate in vivo intoxication.…”

Section: Introductionmentioning

confidence: 99%

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In Vitro Adsorption Studies of Paracetamol to Activated Charcoal Capsule, Powder and Suspension

Panthee¹,

Lohani²

2008

TOTOXIJ

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Abstract:Introduction: Adsorption capacity of activated charcoal to paracetamol was determined at simulated gastric environment, pH 3.4 and simulated intestinal environment pH 7.2. Three formulations of activated charcoal; powder, capsule and suspension were tested. Paracetamol was derived from tablet to simulate in vivo intoxication conditions.Methods: Activated charcoal and paracetamol were mixed at both the pHs. The amount of activated charcoal was varied to obtain activated charcoal-paracetamol ratio from 10:1 to 1:1. Then the mixtures were shaken, filtered and the content of remaining paracetamol was determined by UV spectrophotometer. 4 and 263.64 [229.13; 298.15] at pH 7.2 for suspension. The effect of pH on adsorption capacity was not significant. ResultsDiscussion: Under simulated conditions, the three formulations of activated charcoal adsorbed sufficient amount of paracetamol. The data show that activated charcoal 1g/kg body weight is sufficient a poisoned patient from if given shortly after intoxication.

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“…In this study, it is found that pH had no effect on the adsorption capacity. This is in accordance with other in vitro studies performed with paracetamol [9,10,[14][15][16].…”

Section: Discussionsupporting

confidence: 79%

Section: Discussionmentioning

confidence: 81%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

In Vitro Adsorption Studies of Paracetamol to Activated Charcoal Capsule, Powder and Suspension

Panthee¹,

Lohani²

2008

TOTOXIJ

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show abstract

“…Therefore, in cases of poisoning, adsorption from the small intestine would be more efficient than that occurring in the gastric region, as has been shown in similar studies [4].…”

Section: Discussionmentioning

confidence: 55%

“…Large reductions in drug absorption occur when activated charcoal is administered soon after drug ingestion [2]. Some workers evaluated the adsorption of fluoroquinolones on some pharmaceutical adsorbents; it was observed that activated charcoal had a superior adsorption capacity to bentonite and kaolin [3][4][5].…”

Section: Introductionmentioning

confidence: 99%