Comparison of the Addition of Siberian Ginseng (Acanthopanax senticosus) Versus Fluoxetine to Lithium for the Treatment of Bipolar Disorder in Adolescents: A Randomized, Double-Blind Trial

Weng, Shenhong; Tang, Jihua; Wang, Gaohua; Wang, Xiaoping; Wang, Hui

doi:10.1016/j.curtheres.2007.08.004

Cited by 18 publications

(14 citation statements)

References 14 publications

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“…This hypothesis is in accordance with our findings and publications, where ADAPT-232 and other adaptogens have demonstrated beneficial effects on cognitive function in humans (Bogatova et al, 1997; Hartz et al, 2004; Narimanian et al, 2005; Darbinyan et al, 2007; Fintelmann and Gruenwald, 2007; Weng et al, 2007; Olsson et al, 2009; Aslanyan et al, 2010; Panossian and Wikman, 2010; Edwards et al, 2012). Two clinical pilot studies showed that ADAPT-232 significantly improved attention and increased speed and accuracy during stressful cognitive tasks in comparison to a placebo control (Aslanyan et al, 2010).…”

Section: Discussionsupporting

confidence: 93%

Synergy and Antagonism of Active Constituents of ADAPT-232 on Transcriptional Level of Metabolic Regulation of Isolated Neuroglial Cells

Panossian¹,

Hamm²,

Kadioglu³

et al. 2013

Front. Neurosci.

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Gene expression profiling was performed on the human neuroglial cell line T98G after treatment with adaptogen ADAPT-232 and its constituents – extracts of Eleutherococcus senticosus root, Schisandra chinensis berry, and Rhodiola rosea root as well as several constituents individually, namely, eleutheroside E, schizandrin B, salidroside, triandrin, and tyrosol. A common feature for all tested adaptogens was their effect on G-protein-coupled receptor signaling pathways, i.e., cAMP, phospholipase C (PLC), and phosphatidylinositol signal transduction pathways. Adaptogens may reduce the cAMP level in brain cells by down-regulation of adenylate cyclase gene ADC2Y and up-regulation of phosphodiesterase gene PDE4D that is essential for energy homeostasis as well as for switching from catabolic to anabolic states and vice versa. Down-regulation of cAMP by adaptogens may decrease cAMP-dependent protein kinase A activity in various cells resulting in inhibition stress-induced catabolic transformations and saving of ATP for many ATP-dependant metabolic transformations. All tested adaptogens up-regulated the PLCB1 gene, which encodes phosphoinositide-specific PLC and phosphatidylinositol 3-kinases (PI3Ks), key players for the regulation of NF-κB-mediated defense responses. Other common targets of adaptogens included genes encoding ERα estrogen receptor (2.9–22.6 fold down-regulation), cholesterol ester transfer protein (5.1–10.6 fold down-regulation), heat shock protein Hsp70 (3.0–45.0 fold up-regulation), serpin peptidase inhibitor (neuroserpin), and 5-HT3 receptor of serotonin (2.2–6.6 fold down-regulation). These findings can be reconciled with the observed beneficial effects of adaptogens in behavioral, mental, and aging-associated disorders. Combining two or more active substances in one mixture significantly changes deregulated genes profiles: synergetic interactions result in activation of genes that none of the individual substances affected, while antagonistic interactions result in suppression some genes activated by individual substances. These interactions can have an influence on transcriptional control of metabolic regulation both on the cellular level and the level of the whole organism. Merging of deregulated genes array profiles and intracellular networks is specific to the new substance with unique pharmacological characteristics. Presumably, this phenomenon could be used to eliminate undesirable effects (e.g., toxic effects) and increase the selectivity of pharmacological intervention.

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Section: Discussionsupporting

confidence: 93%

Synergy and Antagonism of Active Constituents of ADAPT-232 on Transcriptional Level of Metabolic Regulation of Isolated Neuroglial Cells

Panossian¹,

Hamm²,

Kadioglu³

et al. 2013

Front. Neurosci.

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“…For depression as the primary diagnosis, no nonrandomised controlled trials were located but two uncontrolled studies were located: one in which 40 cases of “melancholia” were treated with a formula called modified Wen Dan Tang [28] and the other in which 20 patients with prolonged partial remitted major depressive disorder associated with fatigue or loss of energy were treated with Japanese formulae comparable to the two Chinese formulae: Liu Wei Di Huang Wan and Bai Wei Di Huang Wan [29]. The RCTs [30–38] are discussed in the following section, and Figure 1 shows a summary of the selection process and the excluded studies [28, 29, 39–72]. …”

Section: Resultsmentioning

confidence: 99%

“…Several of the herbs have sedative or anxiolytic potential activity which may be beneficial in depressed patients [39]. The remaining herbs have a range of uses and actions and it becomes more apparent why a formula such as Xiao Yao San with or without modifications might be used widely for a range of conditions.…”

Section: Discussionmentioning

confidence: 99%

Chinese Herbal Medicine and Depression: The Research Evidence

Butler

Pilkington

2013

Evidence-Based Complementary and Alternative Medicine

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Background. Alternative approaches for managing depression are often sought and herbal mixtures are widely used in China. The aim of this paper was to provide an overall picture of the current evidence by analysing published systematic reviews and presenting a supplementary systematic review of trials in Western databases. Methods. Searches were conducted using AMED, Cochrane Library, EMBASE, MEDLINE/PubMed, PsycINFO, and trial registers. Results were screened and selected trials were evaluated by two reviewers working independently. Systematic reviews were identified and assessed using key criteria. Results. Five systematic reviews were located addressing the Chinese literature, adjunctive use of Chinese herbs, and the formulae Chaihu-Shugan-San, Xiao Yao San, and Free and Easy Wanderer Plus. The supplementary review located 8 trials, 3 of which were not included in previous reviews. Positive results were reported: no significant differences from medication, greater effect than medication or placebo, reduced adverse event rates when combined or compared with antidepressants. However, limitations in methodology and reporting were revealed. Conclusions. Despite promising results, particularly for Xiao Yao San and its modifications, the effectiveness of Chinese herbal medicine in depression could not be fully substantiated based on current evidence. Further well-designed, well-reported trials that reflect practice may be worth pursuing.

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“…RAS has been used extensively in China, Russia, Korea and Japan as an adaptogen (Brekhman and Dardymov, 1969;Davydov and Krikorian, 2000). Nowadays, there are some RAS products on the market of many countries, including drugs and healthy food (Davydov and Krikorian, 2000;Weng et al, 2007). In China, it is common for people using RAS to make medicinal liquor or to stew pigs, milk *Corresponding author.…”

Section: Introductionmentioning

confidence: 99%

“…cows and pigeons. In vitro and in vivo studies have demonstrated that RAS possesses many pharmacological effects, such as anti-stress, anti-fatigue, immuno-enhancing effect and anti-depressive effect, etc (Weng et al, 2007;Deyama et al, 2001). Among the active components in RAS and its extracts, isofraxidin (Figure 1) is the remarkable one and has been reported to possess strong biological activity (Zhang et al, 2002;Wang et al, 2003).…”

mentioning

confidence: 99%

Preparative enrichment and separation of isofraxidin from Acanthopanax senticosus with HPD100C macroporous resin

Yang¹,

Ge²,

Yang³

et al. 2012

J. Med. Plants Res.

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Isofraxidin is known as the major pharmacological component in Acanthopanax senticosus. In the present study, in order to screen a suitable resin for the preparative separation and purification of isofraxidin, the adsorption and desorption properties of 26 widely used commercial macroporous resins were evaluated. The preliminary research results indicated that HPD100C and HPD300 have better properties. By comparing static adsorption kinetics of HPD100C and HPD300, HPD100C was selected as the most suitable resin. Langmuir and Freundlich isotherms models were used to describe the interaction between solutes and resins at 25, 30, 35°C, respectively, and the equilibrium experimental data fit better to the Langmuir isotherms. Dynamic adsorption and desorption tests have been carried out to optimize the process parameters. The optimal conditions were as follows: For adsorption, the concentration of isofraxidin in sample solution: 0.0436 mg/ml, processing volume: 24 BV, flow rate: 2 BV/h, temperature: 25°C; for desorption, ethanol-water solution: 60:40 (v/v), eluent volume: 4 BV, flow rate: 3 BV/h. Under the conditions aforementioned, the content of isofraxidin increased 23.92-fold and its recovery was 93.79 ± 0.44%. In conclusion, HPD100C demonstrated the best ability for separating isofraxidin among the 26 tested resins.

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Comparison of the Addition of Siberian Ginseng (Acanthopanax senticosus) Versus Fluoxetine to Lithium for the Treatment of Bipolar Disorder in Adolescents: A Randomized, Double-Blind Trial

Abstract: Our study found no significant difference in these adolescents with BD treated with lithium plus adjunctive A senticosus or fluoxetine. All treatments were generally well tolerated.

Cited by 18 publications

References 14 publications

Synergy and Antagonism of Active Constituents of ADAPT-232 on Transcriptional Level of Metabolic Regulation of Isolated Neuroglial Cells

Synergy and Antagonism of Active Constituents of ADAPT-232 on Transcriptional Level of Metabolic Regulation of Isolated Neuroglial Cells

Chinese Herbal Medicine and Depression: The Research Evidence

Preparative enrichment and separation of isofraxidin from Acanthopanax senticosus with HPD100C macroporous resin

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