Comparison of the activity of small molecular interferon inducers: Tilorone and acridine drugs

Gláz, E; Tálas, Margarita

doi:10.1007/bf01317436

Cited by 9 publications

(2 citation statements)

References 16 publications

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“…The results so far have not yielded a more active compound. Other synthetic inducers that have been reported include anionic polymers (28,36,106,125), tilorone (30,58,91), cationic dyes (57), and propane-.diamine (75).…”

Section: Production Of Interferonmentioning

confidence: 99%

Properties of bovine interferons

et al. 1984

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This study was done in an attempt to elucidate some of the properties of bovine IFNs. Maximum levels of both fibroblast and leukocyte IFNs occurred prior to 24 h whereas maximum levels of immune IFN were not reached until after 72 h. The latter species of IFN was unstable at either pH 2 or 56 degrees C whereas both the fibroblast and leukocyte IFNs were more stable under these conditions. Studies of cross-species protection between fibroblast and leukocyte IFNs indicate that the former was more protective for other species than the latter.

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Section: Production Of Interferonmentioning

confidence: 99%

Properties of bovine interferons

et al. 1984

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“…In our study, the existence of the antiviral effect of Tilorone and Cridanimod was confirmed, including the protection from lethal infection in mice (expectedly) and the ability to reduce viremia in rats (less expectedly). The doses in our study are equivalent to the recommended human therapeutic doses, and they represent the lower end of a range of doses in the literature because the majority of papers describe effects at higher dosages (100–250 mg/kg Tilorone, or >300 mg/kg Cridanimod to mice, per os) [ 20 ].…”

Section: Discussionmentioning

confidence: 99%

Tilorone and Cridanimod Protect Mice and Show Antiviral Activity in Rats despite Absence of the Interferon-Inducing Effect in Rats

et al. 2022

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The synthetic compounds, Tilorone and Cridanimod, have the antiviral activity which initially had been ascribed to the capacity to induce interferon. Both drugs induce interferon in mice but not in humans. This study investigates whether these compounds have the antiviral activity in mice and rats since rats more closely resemble the human response. Viral-infection models were created in CD-1 mice and Wistar rats. Three strains of Venezuelan equine encephalitis virus were tested for the performance in these models. One virus strain is the molecularly cloned attenuated vaccine. The second strain has major virulence determinants converted to the wild-type state which are present in virulent strains. The third virus has wild-type virulence determinants, and in addition, is engineered to express green fluorescent protein. Experimentally infected animals received Tilorone or Cridanimod, and their treatment was equivalent to the pharmacopoeia-recomended human treatment regimen. Tilorone and Cridanimod show the antiviral activity in mice and rats and protect the mice from death. In rats, both drugs diminish the viremia. These drugs do not induce interferon-alpha or interferon-beta in rats. The presented observations allow postulating the existence of an interferon-independent and species-independent mechanism of action.

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