Comparison of the actions of acylated and desacylated ghrelin on acid secretion in the rat stomach

Sakurada, Tomoya; Ro, Shoki; Onouchi, Tsuneko; Ohno, Shino; Aoyama, Toshiyuki; Chinen, Katsuya; Takabayashi, Hidehiko; Kato, Shingo; Takayama, Kiyoshige; Yakabi, Koji

doi:10.1007/s00535-010-0269-6

Cited by 28 publications

(14 citation statements)

References 29 publications

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“…Furthermore, ghrelin acts in synergy with gastrin to stimulate gastric acid secretion [249, 250]. Ghrelin, administrated centrally, either induces [251] or inhibits [252, 253] gastric acid secretion and possibly involves the vagus nerve.…”

Section: Physiological Functionsmentioning

confidence: 99%

Structure and Physiological Actions of Ghrelin

2013

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Ghrelin is a gastric peptide hormone, discovered as being the endogenous ligand of growth hormone secretagogue receptor. Ghrelin is a 28 amino acid peptide presenting a unique n-octanoylation modification on its serine in position 3, catalyzed by ghrelin O-acyl transferase. Ghrelin is mainly produced by a subset of stomach cells and also by the hypothalamus, the pituitary, and other tissues. Transcriptional, translational, and posttranslational processes generate ghrelin and ghrelin-related peptides. Homo- and heterodimers of growth hormone secretagogue receptor, and as yet unidentified receptors, are assumed to mediate the biological effects of acyl ghrelin and desacyl ghrelin, respectively. Ghrelin exerts wide physiological actions throughout the body, including growth hormone secretion, appetite and food intake, gastric secretion and gastrointestinal motility, glucose homeostasis, cardiovascular functions, anti-inflammatory functions, reproductive functions, and bone formation. This review focuses on presenting the current understanding of ghrelin and growth hormone secretagogue receptor biology, as well as the main physiological effects of ghrelin.

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Section: Physiological Functionsmentioning

confidence: 99%

Structure and Physiological Actions of Ghrelin

2013

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“…Ghrelin through GHS‐R1a has been shown to exert roles including the stimulation of growth hormone release, the regulation of glucose homeostasis, memory and learning processing, food addiction and neuroprotection 4 . Ghrelin is responsible for many other effects which are independent of GHS‐R1a 2 , and it also regulates gastric acid secretion and gastrointestinal motility 5,6 …”

Section: Introductionmentioning

confidence: 99%

“…4 Ghrelin is responsible for many other effects which are independent of GHS-R1a 2 , and it also regulates gastric acid secretion and gastrointestinal motility. 5,6 via mechanisms that are dependent on or independent of GHS-R1a. 7 Ghrelin has a positive effect on the proliferation of cardiomyocytes, 8 cardiac microvascular endothelial cells, 9 adipocytes, 10 osteoblastic cells, 11 pancreatic b-cells 12 and endometrial cancer cells 13 , but has an inhibitory effect on breast, 14 adrenocortical, 15 prostate 16 and thyroid carcinoma cell lines 17 .…”

Section: Introductionmentioning

confidence: 99%

The proliferative effects of ghrelin on human gastric cancer AGS cells

Tian

Fan

2012

J of Digest Diseases

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“…Octanoylated ghrelin regulates food intake by inducing hyperphagia and increasing gastrointestinal motility, modulates glucose metabolism by altering insulin secretion and sensitivity, as well as stimulates adiposity by increasing lipid storage and/or decreasing lipid expenditure (Li et al, ). Recent studies also suggest that acyl‐ghrelin stimulates gastric acid secretion via a mechanism involving the activation of the vagus nerve and histamine synthesis and release, while the desacyl‐ghrelin form has no action on gastric acid secretion (Sakurada et al, ). In addition, studies have revealed a biphasic action of acyl‐ghrelin on thermogenesis, reducing body temperature at low acyl‐ghrelin levels (Lawrence, Snape, Baudoin, & Luckman, ), whereas increasing body temperature at high acyl‐ghrelin levels (Jászberényi, Bujdosó, Bagosi, & Telegdy, ).…”

Section: Discussionmentioning

confidence: 99%

Molecular cloning and expression of ghrelin in the hypothalamus–pituitary–gastrointestinal tract axis of the Yak (Bos grunniens) in the Qinghai–Tibetan Plateau

Ding

Zhang

JiaLong

et al. 2018

Anat Histol Embryol

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Ghrelin is a very important brain-gut peptide that modulates appetite and energy metabolism in mammals. The yak is the only large mammal that can adapt to the cold temperatures and hypoxia conditions present in the Qinghai-Tibet Plateau. However, there are no reports on ghrelin molecular characterization and expression in the hypothalamus-pituitary-digestive tract axis of the yak to date. In this study, the coding region sequence of the yak ghrelin, containing a complete ORF (351) encoding for 117 amino acids, was cloned. Immunohistochemistry analysis of the yak samples showed that ghrelin-immunoreactive cells were expressed at the arcuate nucleus (ARC), the ventromedial nucleus (VMN), the dorsomedial nucleus (DMN) of the hypothalamus and also at the anterior pituitary. Ghrelin-positive cells were also present in approximately two thirds of the submucosa of the abomasum fundic gland and mucous layer of the duodenum intestinal gland. Ghrelin's mRNA highest expression occurred in the abomasum sample, followed by the duodenum, hypothalamus and lowest at the pituitary gland. The level of ghrelin mRNA measured in yak was higher than in cattle for all the tissues that were compared. The ghrelin protein and mRNA expression profiles were similar. These data imply that the high expression of ghrelin in the hypothalamus-pituitary-digestive tract axis of yak could aid adaptation to the extreme environment better than cattle, by improving appetite and fat accumulation, regulating body temperature and reducing energy consumption via regulating energy metabolism.

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Comparison of the actions of acylated and desacylated ghrelin on acid secretion in the rat stomach

Cited by 28 publications

References 29 publications

Structure and Physiological Actions of Ghrelin

Structure and Physiological Actions of Ghrelin

The proliferative effects of ghrelin on human gastric cancer AGS cells

Molecular cloning and expression of ghrelin in the hypothalamus–pituitary–gastrointestinal tract axis of the Yak (Bos grunniens) in the Qinghai–Tibetan Plateau

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