Comparison of the action of lysergic acid diethylamide and apomorphine on the copulatory response in the female rat

Eliasson, Mona; Meyerson, Bengt J.

doi:10.1007/bf00426833

Cited by 29 publications

(11 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The choice for apomorphine, ±8‐OH‐DPAT, and paroxetine were based on studies described in the literature. Several studies showed the inhibiting effect of apomorphine on female sexual behavior, by a decrease in proceptive behavior [23], lordosis [24–26], and incentive motivation [23] after administration of dopamine‐increasing agents. Also the inhibiting effect of ±8‐OH‐DPAT on lordosis behavior [27–29] was described in the literature in the past.…”

Section: Introductionmentioning

confidence: 99%

A New Female Rat Animal Model for Hypoactive Sexual Desire Disorder; Behavioral and Pharmacological Evidence

Snoeren

Chan

Jong

et al. 2011

The Journal of Sexual Medicine

View full text Add to dashboard Cite

Introduction Female sexual dysfunction (FSD) affects 33–48% of women. Female rats with low sexual activity might model FSD. Aim In this study, we have investigated whether in a population of normal female rats, subpopulations of rats exist with different levels of sexual behavior. Methods Sexually experienced, intact, estradiol-primed female rats were placed in an empty compartment adjacent to a compartment with a male. The females were allowed, during 30 minutes, to switch between the compartments via a hole through which only the females could pass (paced mating). Next, we investigated the acute effects on female sexual behavior of apomorphine, a D1- and D2-type dopamine receptor agonist, (+/–)-8-hydroxy-2-(dipropylamino)tetralin hydrobromide (±8-OH-DPAT), a 5-HT1A receptor agonist, and paroxetine, a selective serotonin reuptake inhibitor. Main Outcome Measures Time spent in compartments, proceptive behaviors, contact–return latencies, and percentages of exits were quantified. Results Based on their behavior in the paced mating sex test, estradiol-primed, intact female rats can be divided into three groups: those that mostly avoid the male, a large middle group, and those that mostly approach the male. The avoiders also showed significantly less proceptive behavior than the male approachers. The sexual behavior of the females was relatively stable over time, suggesting the existence of different endophenotypes in female rats. Apomorphine and ±8-OH-DPAT had an inhibiting effect on sexual behavior, but only females dosed with apomorphine showed a different response in avoiders and approachers, more inhibiting effect in avoiders than approachers. Paroxetine had no effect on proceptive behavior. Discussion The stable, male-avoiding behavior of some females might correspond to the characteristics of women with FSD. Therefore, these avoiders are a promising new model for FSD, specifically for sexual desire and/or arousal disorders. Furthermore, the apomorphine data suggest that differences in the dopamine system may (partly) underlie the differences in sexual behaviors between avoiders and approachers.

show abstract

Section: Introductionmentioning

confidence: 99%

A New Female Rat Animal Model for Hypoactive Sexual Desire Disorder; Behavioral and Pharmacological Evidence

Snoeren

Chan

Jong

et al. 2011

The Journal of Sexual Medicine

View full text Add to dashboard Cite

show abstract

“…Some authors have claimed that LSD also influcences dopaminergic receptors ( Grabowska et aL, 1974;Pieri et al, 1974;Da Prada et aL, 1975). However, Eliasson and Meyerson (1976) demonstrated that the predominant action of LSD on the female copulatory response is not mediated by increased dopamine activity, as the selective dopamine antagonist pimozide did not prevent the LSD-induced decrease in L.R. Since tritiated LSD binds to 5-HT1 and 5-HT 2 receptors to the same extent (Peroutka and Snyder, 1979), we found the drug useful in the present study, where the population of 5-HT receptors involved in the lordotic behavior was investigated.…”

Section: Discussionmentioning

confidence: 95%

“…Compounds that reduce the 5-HT level in the brain facilitate lordosis, and drugs that increase brain 5-HT inhibit it (Meyerson et al, 1973;Meyerson et aL, 1974;Everitt et aL, 1975;Meyerson and Eliasson, 1977;Meyerson and Malmnds, 1978;Sietnieks and Meyerson, 1980, 1983). In addition, a variety of facilitatory and inhibitory actions appear to be exerted by other neurotransmitters such as dopamine (Everitt et aL, 1975;Eliasson and Meyerson, 1976;Foreman and Moss, 1979), norepinephrine (Foreman and Moss, 1978;Glaude, 1979) andacetylcholine (Lindstr6m, 1973;Clemens et aL, 1981).…”

Section: Discussionmentioning

confidence: 97%

“…The time-interval between antagonist and LSD treatment was based on the optimal delay taken from other studies and pilot experiments (Colpaert et aL, 1979(Colpaert et aL, , 1982. The LSD dose used has been demonstrated in previous studies at our laboratory (Eliasson, 1976(Eliasson, , 1977Sietnieks and Meyerson, 1980) to produce submaximal inhibition of L.R. under these conditions.…”

Section: Lordotic Response (Lr)mentioning

confidence: 93%

See 1 more Smart Citation

Involvement of 5-HT2 receptors in the LSD- and L-5-HTP-induced suppression of lordotic behavior in the female rat

Sietnieks

1985

J. Neural Transmission

View full text Add to dashboard Cite

Copulatory behavior in the ovariectomized rat, the lordotic response (L.R.), was induced by estrogen followed by progesterone. L.R. is inhibited by lysergic acid diethylamide (LSD) (greater than or equal to 0.05 mg/kg) and by Levo-5-hydroxytryptophan (L-5-HTP) (greater than or equal to 2.5 mg/kg). The effects of the putative 5-HT antagonists lisuride, metergoline, methysergide, mianserin, cinanserin, cyproheptadine, pirenperone and altanserin on the LSD-induced inhibition of L.R. were tested. Lisuride, metergoline, methysergide and mianserin were found to have no LSD-blocking effect. In contrast, cinanserin, cyproheptadine and pirenperone acted antagonistically to LSD, within a critical dose range. The selective 5-hydroxytryptamine2 (5-HT2) receptor antagonist altanserin effectively prevented the LSD-induced inhibition of L.R., and the doses required (0.05-0.20 mg/kg) indicated a comparatively high antagonistic potency. In addition altanserin (0.2 mg/kg) effectively prevented the lordosis inhibitory effect induced by L-5-HTP (2.5 mg/kg), after pretreatment with pargyline and RO4-4602. It is suggested that the suppression of copulatory behavior caused by LSD and L-5-HTP is mediated by 5-HT2 receptors.

show abstract

“…48,49 On the other Dopamine and sexual function F Giuliano and J Allard hand, apomorphine was found to be able to increase the lordotic response of ovariectomised rats treated with oestrogen and progesterone when given systemically. 50 Stimulation of D 2 receptors by either LY171555 or LY163502 was also found to increase the lordotic response of low receptive ovariectomised oestrogen treated rats.…”

Section: Involvement Of Da In Female Rat Sexual Motivationmentioning

confidence: 99%

Dopamine and sexual function

Giuliano

Allard²

2001

Int J Impot Res

100

View full text Add to dashboard Cite

The use of the D 1 =D 2 dopamine receptor agonist apomorphine SL for the treatment of erectile dysfunction provides a strong support in favour of a participation of the dopaminergic system in the control of sexual function. However, the exact involvement of dopamine in sexual motivation and in the control of genital arousal in humans is unknown. In contrast, experimental data suggest an implication of dopamine at all these stages of the copulatory behaviour in rodents. The release of dopamine at the level of the nucleus accumbens, which is innervated by the mesolimbic dopaminergic pathway originating in the ventral tegmental area, is positively implicated in the pre-copulatory or appetitive phase in male rats. There is also a permissive role in the copulatory or consumatory phase for dopamine released at the level of the median pre-optic area, which receives projection from the dopaminergic incertohypothalamic pathway within the hypothalamus. It is noteworthy that these participations of the dopaminergic system are not specific to sexual behaviour but rather reflect the more general involvement of dopamine in the regulation of cognitive, integrative and reward processes. Due to its role in the control of locomotor activity, the integrity of the nigrostriatal dopaminergic pathway is also essential for the display of copulatory behaviour. Somehow more specific to sexual function, it is likely that dopamine can trigger penile erection by acting on oxytocinergic neurons located in the paraventricular nucleus of the hypothalamus, and perhaps on the pro-erectile sacral parasympathetic nucleus within the spinal cord. The counterpart of such regulation of the genital arousal by dopamine has not yet been established in females. In conclusion, the central dopaminergic system is a key element of the control of sexual function.

show abstract

Comparison of the action of lysergic acid diethylamide and apomorphine on the copulatory response in the female rat

Cited by 29 publications

References 21 publications

A New Female Rat Animal Model for Hypoactive Sexual Desire Disorder; Behavioral and Pharmacological Evidence

A New Female Rat Animal Model for Hypoactive Sexual Desire Disorder; Behavioral and Pharmacological Evidence

Involvement of 5-HT2 receptors in the LSD- and L-5-HTP-induced suppression of lordotic behavior in the female rat

Dopamine and sexual function

Contact Info

Product

Resources

About