Comparison of the abilities of eight acoustic techniques to detect and size a single bubble

Leighton, Timothy G.; Phelps, A.D.; Ramble, D.G.; Sharpe, D.A.

doi:10.1016/0041-624x(96)00053-4

Cited by 58 publications

(39 citation statements)

References 6 publications

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“…The smallest displacements are observed at the lens center making it most susceptible to error. Estimating bubble radius using optical methods or nonlinear acoustical methods based on bubble resonant effects may be more accurate (Leighton et al, 1996).…”

Section: Discussionmentioning

confidence: 99%

Mapping age-related elasticity changes in porcine lenses using bubble-based acoustic radiation force

Erpelding

Hollman

O’Donnell

2007

Experimental Eye Research

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Bubble-based acoustic radiation force aims to measure highly localized tissue viscoelastic properties. In the current investigation, acoustic radiation force was applied to laser-induced bubbles to measure age-related changes in the spatial distribution of elastic properties within in vitro porcine lenses. A potential in vivo technique to map lens elasticity is crucial to understanding the onset of presbyopia and develop new treatment options. Bubble-based acoustic radiation force was investigated as a technique to measure the spatial elasticity distribution of the lens in its natural state without disrupting the lens capsule.Laser-induced optical breakdown (LIOB) generated microbubbles in a straight line across the equatorial plane of explanted porcine lenses with 1 mm lateral spacing. Optical breakdown occurs when sufficiently high threshold fluence is attained at the focus of femtosecond pulsed lasers, inducing plasma formation and bubble generation. A two-element confocal ultrasonic transducer applied 6.5 ms acoustic radiation force-chirp bursts with the 1.5 MHz outer element while monitoring bubble position within the lens using pulse-echoes with the 7.44 MHz inner element. A crosscorrelation method was used to measure bubble displacements and determine exponential time constants of the temporal responses. Maximum bubble displacements are inversely proportional to the local Young's modulus, while time constants are indicative of viscoelastic properties.The apparent spatial elasticity distributions in 41 porcine lenses, ranging from 4 months to 5 years in age, were measured using bubble-based acoustic radiation force. Bubble displacements decrease closer to the porcine lens center, suggesting that the nucleus is stiffer than the cortex. Bubble displacements decrease with increasing lens age, suggesting that porcine lenses become stiffer with age. Bubble-based acoustic radiation force may be well-suited as a potential in vivo technique to spatially map elastic properties of the lens and guide therapeutic procedures aimed at restoring accommodation.

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Section: Discussionmentioning

confidence: 99%

Mapping age-related elasticity changes in porcine lenses using bubble-based acoustic radiation force

Erpelding

Hollman

O’Donnell

2007

Experimental Eye Research

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“…The question is to what extent that answer is accurate, which cannot be ascertained without independent measurements, and certainly is a question which should be asked whenever the environmental conditions differ significantly from the forward model on which the physics is based (Leighton et al 1998b(Leighton et al , 2002Boyd & Varley 2001;Manasseh et al 2001). While such independent measurements can be conducted to validate the technique (Leighton et al 1996(Leighton et al , 1997, in the field they may not be available, and so tests should be performed to examine whether the estimated bubble spectral generation rate can be discounted. A minimum test (which tests the process, not the model) is to determine whether the measured acoustic spectrum is reconstituted, when the estimated bubble spectral generation rate is inserted into the forward problem.…”

Section: The Inverse Problemmentioning

confidence: 99%

Quantification of undersea gas leaks from carbon capture and storage facilities, from pipelines and from methane seeps, by their acoustic emissions

Leighton

White

2011

Proc. R. Soc. A.

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In recent years, because of the importance of leak detection from carbon capture and storage facilities and the need to monitor methane seeps and undersea gas pipelines, there has been an increased requirement for methods of detecting bubbles released from the seabed into the water column. If undetected and uncorrected, such leaks can generate huge financial and environmental losses. This paper describes a theory by which the passive acoustic signals detected by a hydrophone array can be used to quantify gas leakage, providing a practical (as opposed to research), passive and remote detection system which can monitor over a period of years using simple instrumentation. The sensitivity in detecting and quantifying the flux of gas is shown to exceed by more than two orders of magnitude the sensitivity of the current model-based techniques used commercially for gas leaks from large, long pipelines.

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“…12 Use of the above methods is well-known in relation to the detection of bubbles during decompression, or phospholipidcoated micro-bubbles in order to increase ultrasonic image contrast. 13,14 The peculiarity of measurement conditions at this paper is primarily that the environmental parameters and structures exposed to the optical emission and emerging acoustic°ows are constantly changing. Secondly, the emerging bubbles have a wide range of sizes: from a few microns, which are prone to cavitation, to ones which are 100s of microns across and which can be observed visually.…”

Section: Introductionmentioning

confidence: 99%

On the possible ultrasonic inspection of micro-bubbles generated by the optical fiber tip

Казаков

Sanin

Kamensky

2016

J. Innov. Opt. Health Sci.

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We demonstrate the possibility of detection and monitoring of bubbles emerging near the tip of an optical¯ber by means of ultrasonic method. The excitation of bubbles at their resonant frequencies is performed using short ultrasonic pulses having a wide frequency range simultaneously with their modulation by means of a long pulse of a monochromatic frequency. This method allows detection of bubbles of various sizes. Used signal processing method, which allows increased bubble detection accuracy, is proposed for research in environments of biological-like medium which show continuous variations in structure and properties when exposed to optical emission. The method has been demonstrated on model objects: in a liquid and in a biological tissue phantom using various methods of bubble generation (hydrolysis and optical emission). We studied bubble formation by the tip of a¯ber of the surgical laser LSP-007/10 \IRE Polus" with a wavelength of 0.97 m coated with a highly absorbing graphite layer.

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Comparison of the abilities of eight acoustic techniques to detect and size a single bubble

Cited by 58 publications

References 6 publications

Mapping age-related elasticity changes in porcine lenses using bubble-based acoustic radiation force

Mapping age-related elasticity changes in porcine lenses using bubble-based acoustic radiation force

Quantification of undersea gas leaks from carbon capture and storage facilities, from pipelines and from methane seeps, by their acoustic emissions

On the possible ultrasonic inspection of micro-bubbles generated by the optical fiber tip

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