Comparison of the 5-Year Outcome and Morbidity of Three-Dimensional Conformal Radiotherapy Versus Transperineal Permanent Iodine-125 Implantation for Early-Stage Prostatic Cancer

Zeléfsky, Michael J.; Wallner, Kent E.; Chen, Ling; Raben, Adam; Hollister, Timothy; Wolfe, Theresa; Grann, Alison; Gaudin, Paul B.; Fuks, Zvi; Leibel, Steven A.; Walsh, Patrick C.

doi:10.1016/s0022-5347(05)68364-4

Cited by 25 publications

(35 citation statements)

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“…The clinical results ͑survival͒ associated with this technique are, up to now, on par with external beam and prostatectomy. [3][4][5][6][7][8][9][10][11] As with external beam radiation therapy, 12,13 permanent prostate implant is a treatment for which there is a dose-outcome correlation, pointing out the importance of the planning process. 14 One of the critical steps of the technique is the treatment planning: the number of seeds to be used and their positions have to be chosen to reach an optimal therapeutic efficiency.…”

Section: Introductionmentioning

confidence: 99%

Impact of interseed attenuation and tissue composition for permanent prostate implants

et al. 2006

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The purpose is to evaluate the impact of interseed attenuation and prostate composition for prostate treatment plans with 125I permanent seed implants using the Monte Carlo (MC) method. The effect of seed density (number of seeds per prostate unit volume) is specifically investigated. The study focuses on treatment plans that were generated for clinical cases. For each plan, four different dose calculation techniques are compared: TG-43 based calculation, superposition MC, full MC with water prostate, and full MC with realistic prostate tissue. The prostate tissue description is from the ICRP report 23 (W. S. Snyer, M. J. Cook, E. S. Nasset, L. R. Karkhausen, G. P. Howells, and I. H. Tipton, "Report of the task group on reference man," Technical Report 23, International Commission on Radiological Protection, 1974). According to the comparisons, the seed density has an influence on interseed attenuation. A plan with a typical low seed density (42 0.6 mCi seeds in a 26 cm3 prostate) suffers a 1.2% drop in the CTV D90 value due to interseed attenuation. A drop of 3.0% is calculated for a higher seed density (75 0.3 mCi seeds, same prostate). The influence of the prostate composition is similar for all seed densities and prostate sizes. The difference between MC simulations in water and MC simulations in prostate tissue is between 4.4% and 4.8% for the D90 parameter. Overall, the effect on D90 is ranging from 5.8% to 12.8% when comparing clinically approved TG-43 and MC simulations in prostate tissue. The impact varies from one patient to the other and depends on the prostate size and the number of seeds. This effect can reach a significant level when reporting correlations between clinical effect and deposited dose.

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Section: Introductionmentioning

confidence: 99%

Impact of interseed attenuation and tissue composition for permanent prostate implants

et al. 2006

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“…Proctitis is possible and incontinence lasting for >3 months has been reported, but no incontinence serious enough to require pads persisted for >6 months. Zelefsky et al [13] reported a 21% rate of erectile dysfunction among patients who were potent before treatment (which is worse than the rate initially reported). In summary, among those patients who have undergone BT, there are consistently fewer with subsequent incontinence and impotence.…”

Section: Morbiditymentioning

confidence: 88%

Brachytherapy versus radical prostatectomy

Ravery

2001

BJU International

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“…Although the operation is effective, it is a major procedure and may be associated with major morbidities [2]. External beam radiotherapy and brachytherapy achieve an encouraging PSA outcome, yet complications can be considerable [3]. In addition, most men in whom radiotherapy fails have higher grade cancer and radical prostatectomy in this situation is technically difficult and associated with significant complications [4].…”

Section: Introductionmentioning

confidence: 99%