Comparison of Test Your Memory and Montreal Cognitive Assessment Measures in Parkinson’s Disease

Abstract

Background. MoCA is widely used in Parkinson's disease (PD) to assess cognition. The Test Your Memory (TYM) test is a cognitive screening tool that is self-administered. Objectives. We sought to determine (a) the optimal value of TYM to discriminate between PD patients with and without cognitive deficits on MoCA testing, (b) equivalent MoCA and TYM scores, and (c) interrater reliability in TYM testing. Methods. We assessed the discriminant ability of TYM and the equivalence between TYM and MoCA scores and measured the interrater reliability between three raters. Results. Of the 135 subjects that completed both tests, 55% had cognitive impairment according to MoCA. A MoCA score of 25 was equivalent to a TYM score of 43-44. The area under the receiver operator characteristic (ROC) curve for TYM to differentiate between PD-normal and PD-cognitive impairment was 0.82 (95% CI 0.75 to 0.89). The optimal cutoff to distinguish PD-cognitive impairment from PD-normal was ≤45 (sensitivity 90.5%, specificity 59%) thereby correctly classifying 76.3% of patients with PD-cognitive impairment. Interrater agreement was high (0.97) and TYM was completed in under 7 minutes (interquartile range 5.33 to 8.52 minutes). Conclusions. The TYM test is a useful and less resource intensive screening test for cognitive deficits in PD.

Cognition and connectomes in nondementia idiopathic Parkinson’s disease

“…Although James Parkinson initially proposed that PD did not progress to the cerebrum (Parkinson, 2002 ), there is now substantial evidence that PD can compromise higher cortical cognitive processes. The progression may not be the same for all individuals with PD, however; some individuals remain with primary processing-speed impairments while others may present with primary memory impairments and are at greater risk for dementia (Henderson et al, 2016 ; Janvin, Larsen, Aarsland, & Hugdahl, 2006 ). Neuroimaging investigations show regional fractional anisotropy (FA) and volumetric gray and white matter (WM) differences in PD and non-PD peers (Price et al, 2016 ; Tanner et al, 2015 ).…”

“…In this work, we performed global (average values for the entire brain network for each participant) and local (average values for every individual node for each participant) connectome analyses. Given the elevated risk of developing dementia associated with amnestic mild cognitive impairment in PD (Henderson et al, 2016 ), in this study we examined structural connectome differences in people with PD who are cognitively well relative to individuals with PD who meet criteria for amnestic MCI. We also explored the correlations between topological connectome indices and the most common cognitive vulnerabilities of PD (i.e., processing speed, working memory, and episodic memory; Zgaljardic, Borod, Foldi, & Mattis, 2003 ).…”

Determining a Short Form Montreal Cognitive Assessment (s-MoCA) Czech Version: Validity in Mild Cognitive Impairment Parkinson’s Disease and Cross-Cultural Comparison

“…However, administration time is considered a disadvantage of the MoCA (Gill et al, 2008; Roalf et al, 2016; Zadikoff et al, 2008). The standard MoCA takes about 10 to 15 minutes to administer even in the healthy population (Henderson et al, 2016; Kopecek et al, 2017; Roalf et al, 2016) and is approximately two times longer than the administration time of the MMSE (Stepankova et al, 2015). However, recent work has created validated short forms of the MoCA (s-MoCA; Horton et al, 2015; Panenková, Kopeček, & Lukavský, 2016; Roalf et al, 2016).…”

The Clinical Utility of the TYM and RBANS in a One-Stop Memory Clinic in Singapore: A Pilot Study

“…3 To date, only 1 study compared the discriminant validity of the TYM and MoCA, although it was in a Parkinson disease (PD) population. 19 The TYM at its optimal cutoff point (<46) was equivalent to the MoCA (<26) in detecting CI in patients with PD (TYM: sensitivity: 0.91; specificity: 0.59). 19 Our finding that the TYM and the MoCA are equivalent concurs with this study.…”