Comparison of temporal changes in established cardiovascular biomarkers after acute coronary syndrome between Caucasian and Chinese patients with diabetes mellitus

Buljubasic, Nermina; Zhao, Wei; Cheng, Jin M.; Li, Huijuan; Oemrawsingh, Rohit M.; Akkerhuis, Martijn; Yu, Haiyi; Zhou, Lequn; Wu, Yang-feng; Boersma, Eric; Gao, Wei

doi:10.1080/1354750x.2020.1759692

Cited by 4 publications

(3 citation statements)

References 26 publications

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“…We further report differences by self-reported race, with Asian individuals having higher 2-AAA than other groups. Individuals of Asian ancestry have relatively higher risk of T2D and some CVD compared with individuals of European ancestry with the same risk factor profile ( 29 , 30 ). The mechanisms underlying this are incompletely understood, and the risk factors for CVD in Asians may differ when compared with European ancestry ( 31 ).…”

Section: Discussionmentioning

confidence: 99%

Association of alpha-aminoadipic acid with cardiometabolic risk factors in healthy and high-risk individuals

Desine,

Gabriel,

Smith

et al. 2023

Front. Endocrinol.

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IntroductionPlasma levels of the metabolite alpha-aminoadipic acid (2-AAA) have been associated with risk of type 2 diabetes (T2D) and atherosclerosis. However, little is known about the relationship of 2-AAA to other cardiometabolic risk markers in pre-disease states, or in the setting of comorbid disease.MethodsWe measured circulating 2-AAA using two methods in 1) a sample of 261 healthy individuals (2-AAA Study), and 2) in a sample of 134 persons comprising 110 individuals with treated HIV, with or without T2D, a population at high risk of metabolic disease and cardiovascular events despite suppression of circulating virus, and 24 individuals with T2D without HIV (HATIM Study). We examined associations between plasma 2-AAA and markers of cardiometabolic health within each cohort.Results and discussionWe observed differences in 2-AAA by sex and race in both cohorts, with higher levels observed in men compared with women, and in Asian compared with Black or white individuals (P<0.05). There was no significant difference in 2-AAA by HIV status within individuals with T2D in the HATIM Study. We confirmed associations between 2-AAA and dyslipidemia in both cohorts, where high 2-AAA associated with low HDL cholesterol (P<0.001) and high triglycerides (P<0.05). As expected, within the cohort of people with HIV, 2-AAA was higher in the setting of T2D compared to pre-diabetes or normoglycemia (P<0.001). 2-AAA was positively associated with body mass index (BMI) in the 2-AAA Study, and with waist circumference and measures of visceral fat volume in HATIM (all P<0.05). Further, 2-AAA associated with increased liver fat in persons with HIV (P<0.001). Our study confirms 2-AAA as a marker of cardiometabolic risk in both healthy individuals and those at high cardiometabolic risk, reveals relationships with adiposity and hepatic steatosis, and highlights important differences by sex and race. Further studies are warranted to establish molecular mechanisms linking 2-AAA to disease in other high-risk populations.

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Section: Discussionmentioning

confidence: 99%

Association of alpha-aminoadipic acid with cardiometabolic risk factors in healthy and high-risk individuals

Desine,

Gabriel,

Smith

et al. 2023

Front. Endocrinol.

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“…Previous studies have shown that cardiovascular biomarkers, low-density lipoprotein (LDL), total cholesterol (TC), cardiac troponin T and C-reactive protein are systematically higher in Caucasian diabetic patients with acute coronary syndrome than in their Chinese counterparts [17]. Ethnic variations in cardiometabolic risk factors contribute at least in part to the excess CVDs in ethnic minorities.…”

Section: Introductionmentioning

confidence: 99%

Differences in cardiometabolic risk profiles between Chinese and Finnish older adults with glucose impairment and central obesity

Zhang

Voutilainen

et al. 2022

J Endocrinol Invest

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Background Obesity and ethnicity play important roles in cardiovascular complications in patients with type 2 diabetes mellitus (T2DM). This study aimed to compare cardiometabolic risk profiles between Chinese and Finnish older adults of central obesity with prediabetes or T2DM. Methods Study subjects were 60–74 years old and originated from two population samples. The Finnish subjects came from the Kuopio Ischemic Heart Disease (KIHD) study (n = 1089), and the Chinese subjects came from the Shanghai High-risk Diabetic Screen (SHiDS) study (n = 818). The KIHD and SHiDS studies used similar questionnaires to determine participants’ baseline characteristics regarding the history of medication use and diseases and lifestyle factors. All study subjects participated in glucose tolerance tests and anthropometry assessments, including waist circumference measurements. Results Among study subjects of central obesity with prediabetes (n = 298), fasting and 2-h glucose, and fasting insulin and insulin resistance were significantly higher in Chinese than in Finnish (p < 0.0001–0.016). In addition, triglyceride (TG) level was higher and the low-density lipoprotein cholesterol (LDL) and LDL to high-density lipoprotein cholesterol (HDL) ratio were lower in Chinese than in Finnish (p < 0.0001–0.003). Among subjects of central obesity with T2DM (n = 251), Chinese subjects had significantly less proportions of antihypertensive, glycaemic control medication, and statin users as well as lower level of physical activity (p < 0.0001 for all), while higher blood pressure (p = 0.002 for systolic blood pressure and p < 0.0001 for diastolic blood pressure), TG levels (p < 0.05) and HDL (p = 0.002) than the Finnish counterparts. There were no differences in β-cell function (HOMA-β) between Chinese and Finnish both in prediabetes and T2DM. Conclusions Our results indicated that Chinese and Finnish older adults of central obesity with prediabetes and T2DM had similar β-cell function. However, Chinese individuals with prediabetes are prone to insulin resistance. Meanwhile, lipid metabolism dysfunction is also different between Chinese and Finnish. Chinese older adults of central obesity with prediabetes showed higher TG, but Finnish showed higher LDL and LDL/HDL. Strategic for T2DM prevention and treatment should be ethnically specific.

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“…Previous studies have shown that cardiovascular biomarkers, low-density lipoprotein (LDL), total cholesterol (TC), cardiac troponin T and C-reactive protein are systematically higher in Caucasian diabetic patients with acute coronary syndrome than in their Chinese counterparts [15]. Ethnic variations in cardiometabolic risk factors contribute at least in part to the excess CVDs in ethnic minorities.…”

Section: Introductionmentioning

confidence: 99%

Differences in Cardiometabolic Risk Profiles Between Chinese and Finnish Older Adults with Glucose Impairment and Central Obesity

Le¹,

Zhang²,

Voutilainen³

et al. 2021

Preprint

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Background Obesity and ethnicity play important roles in cardiovascular complications in patients with T2DM. This study aimed to compare cardiometabolic risk profiles between Chinese and Finnish older adults with prediabetes or type 2 diabetes mellitus (T2DM) and central obesity. Methods Study subjects were 60-74 years old and originated from two population samples. The Finnish subjects came from the Kuopio Ischemic Heart Disease (KIHD) study (n = 1089), and the Chinese subjects came from the Shanghai High-risk Diabetic Screen (SHiDS) study (n = 818). The KIHD and SHiDS studies used similar questionnaires to determine participants’ baseline characteristics regarding the history of medication use and diseases and lifestyle factors. All study subjects participated in glucose tolerance tests and anthropometry assessments, including waist circumference measurements. Results Among study subjects with prediabetes and central obesity (n = 298), fasting glucose, 2-h glucose, fasting insulin, insulin resistance, and triglyceride (TG) levels were significantly higher while the low-density lipoprotein cholesterol (LDL) and LDL to high-density lipoprotein cholesterol (HDL) ratio were lower in Chinese individuals than Finnish individuals (p <0.0001-0.003). Among subjects with T2DM and central obesity (n = 251), Chinese subjects had significantly less proportions of antihypertensive, glycaemic control medication, and statin users as well as lower level of physical activity (p < 0.0001 for all), while higher blood pressure (p = 0.002 for systolic blood pressure and p < 0.0001 for diastolic blood pressure), TG levels (p < 0.05) and HDL (p = 0.002) than the Finnish counterparts. There were no differences in β-cell function (HOMA-β) between Chinese and Finnish both in prediabetes and T2DM. Conclusions Our results indicated that Chinese and Finnish older adults with prediabetes and T2DM had similar β-cell function. However, Chinese individuals with prediabetes are prone to lipid metabolism dysfunction and insulin resistance. Strategies for preventing prediabetes from developing into diabetes in Chinese individuals should be focused on interventions such as exercise to increase insulin sensitivity and prevent insulin resistance. For Finnish individuals with prediabetes, more attention should be given to weight control.

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Comparison of temporal changes in established cardiovascular biomarkers after acute coronary syndrome between Caucasian and Chinese patients with diabetes mellitus

Cited by 4 publications

References 26 publications

Association of alpha-aminoadipic acid with cardiometabolic risk factors in healthy and high-risk individuals

Association of alpha-aminoadipic acid with cardiometabolic risk factors in healthy and high-risk individuals

Differences in cardiometabolic risk profiles between Chinese and Finnish older adults with glucose impairment and central obesity

Differences in Cardiometabolic Risk Profiles Between Chinese and Finnish Older Adults with Glucose Impairment and Central Obesity

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