Comparison of systemic PUVA and NB‐UVB in the treatment of vitiligo: an open prospective study

Bhatnagar, Abha; Kanwar, AJ; Parsad, Davinder; De, Dipankar

doi:10.1111/j.1468-3083.2006.02035.x

Cited by 66 publications

(90 citation statements)

References 13 publications

(31 reference statements)

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“…4,8 In this context, NB-UVB phototherapy is recommended in preference to oral PUVA because of evidence of greater efficacy and safety, as well as because of the substantial repigmentation rates that are achieved, particularly on the face, trunk and proximal extremities. 1,4,[24][25][26] In this regard, a lower likelihood of erythema and xerosis development, carcinogenic effects and a lack of oral treatment obligation were reported advantages of NB-UVB phototherapy when compared with PUVA. 27 Considering the mechanism of action of phototherapy, while failing to achieve complete normalization of levels of oxidantantioxidant markers compared with control levels, the use of NB-UVB phototherapy for 6 months in the present study was associated with significant improvement in oxidantantioxidant imbalance, shown by reduction in MDA levels and an increase in GSH-Px levels.…”

Section: Discussionmentioning

confidence: 99%

Role of oxidative stress in the pathogenesis of vitiligo with special emphasis on the antioxidant action of narrowband ultraviolet B phototherapy

Karsli¹,

Akçalı

Özgöztaşı

et al. 2014

J Int Med Res

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Objectives: To evaluate the role of oxidative stress in the pathogenesis of vitiligo and the effect of narrowband (NB) ultraviolet (UV) B phototherapy on oxidative stress markers. Methods: Patients with vitiligo and healthy control subjects were included in the study. Patients in the vitiligo group were treated with an NB-UVB regimen (3 Â weekly for 6 months). Erythrocyte superoxide dismutase activity (SOD), erythrocyte malonyldialdehyde (MDA) and erythrocyte glutathione peroxidase activity (GSH-Px) levels were assessed in all participants at baseline, and after NB-UVB phototherapy in patients with vitiligo. Results: A total of 24 patients with vitiligo and 27 control subjects were included in the study. Before treatment, erythrocyte MDA levels were significantly higher, and SOD and GSH-Px levels were significantly lower, in patients with vitiligo compared with controls. NB-UVB phototherapy was associated with a significant reduction in MDA levels and a significant increase in GSH-Px levels, compared with baseline, in patients with vitiligo. Conclusion: NB-UVB phototherapy may relieve oxidative stress in patients with vitiligo by reversing the oxidant-antioxidant imbalance that is considered to play a role in the pathogenesis of this disease.

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Section: Discussionmentioning

confidence: 99%

Role of oxidative stress in the pathogenesis of vitiligo with special emphasis on the antioxidant action of narrowband ultraviolet B phototherapy

Karsli¹,

Akçalı

Özgöztaşı

et al. 2014

J Int Med Res

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“…NB-UVB phototherapy is frequently used to treat vitiligo and is considered to be an effective method of treatment (40). However, previous studies have demonstrated that environmental doses of UVB radiation exposure may induce various cutaneous disorders (41,42).…”

Section: Discussionmentioning

confidence: 99%

The effects of phototherapy and melanocytes on keratinocytes

Tang

et al. 2018

Exp Ther Med

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Abstract. Phototherapy is widely used in the treatment of vitiligo. Previous studies have focused on the effects of ultraviolet (UV) radiation on melanocytes; however, the biological effects of phototherapy and melanocytes on keratinocytes remain to be elucidated. To investigate and assess the effects of clinically doses of broad band (BB)-UVA, narrow band (NB)-UVB and melanocytes on human keratinocytes in vitro, clinical doses of BB-UVA or NB-UVB radiation and human melanoma cell A375 co-culture were performed as stress divisors to HaCaT cells. Cell proliferation, expression of protease-activated receptor-2 (PAR-2) and nuclear factor E2-related factor 2 mRNA, lipid peroxidation and intracellular antioxidant level of keratinocytes were analyzed. It was demonstrated that UV radiation inhibited the proliferation of cells apart from following exposure to low dose (1 J/cm 2 ) UVA. Medium dose (5 J/cm 2 ) UVA radiation had no adverse effects on lipid peroxidation and increased antioxidant levels in HaCaT cells. Medium (200 mJ/cm 2 ) and high (400 mJ/cm 2 ) doses of UVB radiation induced cellular damage due to increased lipid peroxidation as indicated by levels of malondialdehyde. Furthermore, A375 co-culture treatment induced a similar effect on the lipid peroxidation of HaCaT as with low dose UVB radiation. Therefore, the results of the present study determined that clinical doses of BB-UVA and NB-UVB radiation had varying effects on proliferation and related protein levels in HaCaT cells. Co-culture with A375 had similar effects as those of low dose UVA and UVB radiation, in which the PAR-2 expression was significantly upregulated.

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“…It has been shown to be more effective than PUVA photochemotherapy, without the adverse side effect profile of psoralen (Table 1) (Bhatnagar, Kanwar et al, 2007;Yones, Palmer et al, 2007). Evidence-based guidelines suggest that NB-UVB should be used instead of PUVA in both adult and pediatric patients who have treatment-resistant disease, widespread involvement (BSA > 10-20%), or disease that severely affects quality of life Gawkrodger, Ormerod et al, 2008;Silverberg, 2010).…”

Section: Nb-uvb Phototherapymentioning

confidence: 99%

Ultraviolet B (UVB) Phototherapy in the Treatment of Vitiligo

Park¹,

Murase²

2011

Vitiligo - Management and Therapy

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Comparison of systemic PUVA and NB‐UVB in the treatment of vitiligo: an open prospective study

Abstract: NB-UVB performed better in comparison to TMP PUVA in terms of mean total repigmentation when traditionally considered therapy-resistant sites were excluded.

Cited by 66 publications

References 13 publications

Role of oxidative stress in the pathogenesis of vitiligo with special emphasis on the antioxidant action of narrowband ultraviolet B phototherapy

Role of oxidative stress in the pathogenesis of vitiligo with special emphasis on the antioxidant action of narrowband ultraviolet B phototherapy

The effects of phototherapy and melanocytes on keratinocytes

Ultraviolet B (UVB) Phototherapy in the Treatment of Vitiligo

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