Comparison of systemic cytokine levels in patients with acute respiratory distress syndrome, severe pneumonia, and controls

Bauer, Torsten T.; Montón, Concepción; Torres, Antoni; Cabello, Hernán; Fillela, Xavier; Maldonado, Abel; Nicolás, José‐María; Zavala, Elisabet

doi:10.1136/thorax.55.1.46

Cited by 149 publications

(114 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…A cytokine-mediated inflammatory response has been well documented in cases of pneumonia and acute respiratory distress syndrome [5,6,7]. However, few studies have focused on the role of these inflammatory mediators in infection by the Influenza A (H 1 N 1 ) virus [8].…”

Section: Introductionmentioning

confidence: 99%

Cytokine levels in bronchoalveolar lavage and serum in 3 patients with 2009 Influenza A(H1N1)v severe pneumonia

Estella

2011

J Infect Dev Ctries

View full text Add to dashboard Cite

Introduction: Pandemic Influenza A (H 1 N 1 )v pneumonia has led to a notable increase of admissions to intensive care units. A cytokinemediated inflammatory response has been well documented in pneumonia and acute respiratory distress syndrome. However, few studies have focused on the role of these inflammatory mediators in infections caused by the Influenza A (H 1 N 1 )v. In this study, we assess the inflammatory response mediated by cytokines at the local and systemic levels in three cases of severe pneumonia caused by Influenza A (H 1 N 1 ) virus. Methodology: Serum and bronchoalveolar lavage samples were obtained from three mechanically ventilated patients diagnosed with Influenza A (H1N1) virus pneumonia by bronchoscopic bronchoalveolar lavage. Levels of interleukin 6 (IL-6), interleukin 8 (IL-8), tumour necrosis factor alpha (TNFα) and interleukin 1 beta (IL-1ß) were meassured in these samples by enzyme-linked immunosorbent assay (ELISA). Results: High levels of C Reactive Protein, Procalcitonin below 1 ng/ml and absence of leukocytosis were common findings in all patients. TNF α and IL-1ß were not detected in the serum. IL-6 levels in serum were (94, pg/ml, 77 pg/ml and 84 pg/ml) respectively in the three patients, while IL-8 levels were (30,2 pg/ml, 128 pg/ml and 40,5 pg/ml). In the BAL samples, only one of the analysed cytokines, IL-1ß was present at detectable levels in two patients (21 pg/ml and 11 pg/ml respectively). Conclusions: Our results support previous findings which suggest that high levels of IL-6 and IL-8 in serum somehow participate in the inflammatory response in severe cases of pandemic influenza pneumonia.

show abstract

Section: Introductionmentioning

confidence: 99%

Cytokine levels in bronchoalveolar lavage and serum in 3 patients with 2009 Influenza A(H1N1)v severe pneumonia

Estella

2011

J Infect Dev Ctries

View full text Add to dashboard Cite

show abstract

“…Others, such as Hyers have found variability in the elevation of TNF-, however, there is speculation that TNF-is an acute phase cytokine and the timing of studies is important for its evaluation (Hyers, 1991). Although Bauer found that the TNF-levels were significantly elevated it was also speculated that the elevation was more related to the severity of the lung disease and could not be extrapolated as a possible diagnostic marker for ARDS (Bauer et al, 2000). TNF-is a known acute phase reactant and is also a cytokine involved in systemic inflammation.…”

Section: Serum Biomarkers In Permeability Edema and Ardsmentioning

confidence: 99%

“…The cytokine, TNFinduces macrophages and T H 1 cells and activates ECs and macrophages (Braun et al, 2005). Studies have been conflicting as far as elevation of TNF-in patients with ARDS pulmonary edema, for example, Bauer demonstrated that TNF-concentrations were significantly higher in patients with ARDS than those of pneumonia or of the control subjects (Bauer et al, 2000). Others, such as Hyers have found variability in the elevation of TNF-, however, there is speculation that TNF-is an acute phase cytokine and the timing of studies is important for its evaluation (Hyers, 1991).…”

Section: Serum Biomarkers In Permeability Edema and Ardsmentioning

confidence: 99%

“…Large amounts of TNF-are released in response to LPS endotoxin, bacterial products and IL-1. TNF-works with IL-1 and IL-6 to produce actions on various organ systems (Schutte et al, 1996;Braun et al, 2005;Bauer et al, 2000). TNF-also induces EC activation and barrier dysfunction both of which occur in the pathogenesis of pulmonary edema and ALI/ARDS.…”

Section: Serum Biomarkers In Permeability Edema and Ardsmentioning

confidence: 99%

See 1 more Smart Citation

Non-Cardiogenic Pulmonary Edema

Gonzales¹,

Verin²

2012

Lung Diseases - Selected State of the Art Reviews

View full text Add to dashboard Cite

“…The systemic level of IL-1β seems to reflect the severity of the lung injury rather than the diagnosis in different lung diseases 70 . The levels of IL-1β in BAL fluid from patients with ARDS did not differ between survivors and non-survivors, but low concentrations of anti-inflammatory cytokines IL-1Ra and IL-10 were associated with worse prognosis 68 .…”

Section: Lungmentioning

confidence: 99%

Interleukin-1 Family: From Genes to Human Disease

Laurincová¹

2000

BIOMED PAP

View full text Add to dashboard Cite

Interleukin-1 (IL-1) is one of the most potent proinflammatory cytokines involved both in physiological immune responses and in the development of various immunopathological disorders. The members of IL-1 family form a complex system with tight regulatory mechanisms and clarifying their role in disease remains in the centre of research interests. This review article except of summarising recent findings about IL-1 family members focuses on associations of IL-1 gene complex polymorphisms with human diseases.

show abstract

Comparison of systemic cytokine levels in patients with acute respiratory distress syndrome, severe pneumonia, and controls

Abstract: Conclusions-Serum TNF-levels were higher in patients with ARDS than in those with severe pneumonia or in control subjects. Multivariate results suggest that the levels of systemic TNF-and IL-1 reflect the severity of the lung injury rather than the diagnosis. (Thorax 2000;55:46-52)

Cited by 149 publications

References 37 publications

Cytokine levels in bronchoalveolar lavage and serum in 3 patients with 2009 Influenza A(H1N1)v severe pneumonia

Cytokine levels in bronchoalveolar lavage and serum in 3 patients with 2009 Influenza A(H1N1)v severe pneumonia

Non-Cardiogenic Pulmonary Edema

Interleukin-1 Family: From Genes to Human Disease

Contact Info

Product

Resources

About