Comparison of Synthetic and Fermentation Chloramphenicol (Chloromycetin) in Rickettsial and Viral Infections

Smadel, Joseph E.; Jackson, Elizabeth B.; Ley, Herbert L.; Lewthwaite, R.

doi:10.3181/00379727-70-16870

Cited by 18 publications

(4 citation statements)

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“…The average day on which therapy was begun for the treated group was 6.2 and the last febrile day of the illness was 7.4. This may be compared with that of the last febrile day of illness in the untreated group; this varied between 12 and 31 and averaged 17.1 days.…”

mentioning

confidence: 99%

Chloramphenicol (Chloromycetin) in the Treatment of Tsutsugamushi Disease (Scrub Typhus)

Smadel¹,

Woodward²,

Ley³

et al. 1949

J. Clin. Invest.

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mentioning

confidence: 99%

Chloramphenicol (Chloromycetin) in the Treatment of Tsutsugamushi Disease (Scrub Typhus)

Smadel¹,

Woodward²,

Ley³

et al. 1949

J. Clin. Invest.

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“…COMMENT A group of older patients with various clinical mani¬ festations and who had diseases associated with hiatus hernia was observed. Although a number of authors 4 have reported the fact that bleeding is found in patients with hiatus hernia, 13 patients in our group had chronic anemia for a comparatively long time before the basic underlying cause-hiatus hernia-was detected. In 2 patients the anemia was so severe that they had been treated for pernicious anemia elsewhere.…”

Section: Report Of Casesmentioning

confidence: 59%

Treatment of Hiatus Hernia in Older Persons

Pickhardt¹

1950

JAMA

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It is of interest to note the anatomic misdirection of fiber that sometimes occurs in other neural regenerations, particularly in the facial nerve. The facial muscles will not always react as they should when a facial nerve regenerates. The amazing thing is that the third nerve will regenerate to the point where, for all practical pur¬ poses, it functions normally. To see one of these nerves at the time of surgical intervention, one would say that the nerve could never regenerate because only the tiniest thread held the two ends together. Many times the portion of the nerve trunk that is left is only about one tenth of the normal diameter of the third nerve. Dr. Smith inquired about the careful obser¬ vation and recording of everything that happens in regard to the movement of the eyeballs and particularly of the pupils. My material has been voluminous, and my associates and I are now gaining enough experience on which to plan our obser¬ vations. A great deal of this material was seen by various ophthalmologists and many neurologists, and we have not really worked out an accurate routine of examination. I do not believe that sympathetic factors have anything to do with causing mul¬ tiple aneurysms. It is fairly well established that most of these are due to a congenital malformation, and I cannot conceive of sympathetic inhibition having anything to do with their formation. The ophthalmologist is most frequently the first to examine patients with intra;ranial aneurysms ; therefore he must be informed as to the appropriate forms of treatment.Clinical experience has shown that esophageal hiatus hernia in older persons often presents diagnostic and therapeutic problems. The reasons for this are that the hiatus hernia may exist without symptoms ; it may produce a syndrome which simulates other diseases, as for example, cholelithiasis or cardiovascular disease ; it may be associated with other diseases and produce complications, the symptoms of which dominate the clinical picture, and, finally, the treatment of hiatus hernia, whether medical or surgical, is not infrequently followed by a recurrence of the symptoms. In this article we wish to stress two aspects of this subject, namely, varied clinical manifestations of associated diseases of hiatus hernia which were encountered in a group of patients and the surgical treatment by phrenic interruption. r CLINICAL STUDY This study is based on a series of 29 patients whose age range was from 50 to 86 years. Seven were men ; 22 were women. In each case the presence of an

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“…Chloramphenicol has shown definite inhibitory activity against several of the Chlamydozoaceae in chick embryos (12,13,92,93,94), but larger doses were required than for comparable effects against rickettsiae. The results with intracerebral and intranasal infections in mice are not outstand ing (73,92,93) and appear about equal to those obtained with penicillin.…”

Section: Virus and Rickettsial Infections 225mentioning

confidence: 99%

Chemotherapy of Virus and Rickettsial Infections

Eaton¹

1950

Annu. Rev. Microbiol.

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Comparison of Synthetic and Fermentation Chloramphenicol (Chloromycetin) in Rickettsial and Viral Infections

Cited by 18 publications

References 0 publications

Chloramphenicol (Chloromycetin) in the Treatment of Tsutsugamushi Disease (Scrub Typhus)

Chloramphenicol (Chloromycetin) in the Treatment of Tsutsugamushi Disease (Scrub Typhus)

Treatment of Hiatus Hernia in Older Persons

Chemotherapy of Virus and Rickettsial Infections

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