Comparison of swept-source OCTA and indocyanine green angiography in central serous chorioretinopathy

Abstract

Background To compare swept-source optical coherence tomography angiography (SS-OCTA) and indocyanine green angiography (ICGA) in patients with central serous chorioretinopathy (CSC). Methods SS-OCTA and ICGA images of 39 eyes with symptomatic CSC were collected and aligned. Spatial overlap of the annotations of the coarse granulated high reflective area on choriocapillary OCTA and the hyperfluorescence area on mid-phase ICGA was calculated according to the Jaccard index (JI). SS-OCTA findings of fellow eyes and changes in SS-OCTA abnormalities during the follow-up were also analyzed. Results Three main types of abnormalities in choriocapillaris SS-OCTA images were found: type A, coarse granulated high reflective area (39 eyes [100%]); type B, roundish dark halo around Type A (32 eyes [82.1%]); and type C, coarse granulated low reflective area (39 eyes [100%]). The mean JI of type A on SS-OCTA and the hyperfluorescence area on ICGA were 0.55 ± 0.15 for grader 1 and 0.49 ± 0.15 for grader 2. The mean area of type A abnormalities on SS-OCTA and hyperfluorescence on ICGA was 3.976 (IQR, 2.139–8.168) and 3.043 (IQR, 1.408–4.909) mm2 (P = 0.199). The areas of type A, B and C abnormalities on SS-OCTA after laser treatment or observation were 3.36mm2 (IQR, 2.399–9.312), 2.9mm2 (IQR, 2.15–3.7), and 0.19mm2 (IQR, 0.08–0.23), respectively, which was smaller than those in the baseline (7.311mm2 (IQR 3.788–11.209), P < 0.001; 4.3mm2 (IQR, 2.8–9.8), P = 0.002;0.33mm2 (IQR, 0.23–0.38), P < 0.001). The change in the type A, B or C area was not significantly different between the two groups (P = 0.679, 0.732, and 0.892). Conclusion The coarse granulated high reflective area in SS-OCTA corresponded well with the hyperpermeability area in ICGA. SS-OCTA promotes noninvasive visualization and follow-up quantifications of the choroidal vasculature in CSC patients.

Correlative study on retinal microvascular changes and sex hormones in male patients with central serous chorioretinopathy

“…In the present study, OCTA revealed that the SCT of the affected eyes of CSC patients was significantly thicker than that of the healthy eyes. Previous researchers speculated that SCT thickening may be associated with choroidal vasodilatation, choroidal vascular hyperpermeability, and choroidal interstitial edema; in addition, SCT thickening has also been proven to be an important trigger of choroidal structural and functional changes [21][22][23]. Moreover, this study also identified a reduced choriocapillary blood flow area in CSC patients compared to their healthy eyes, thus indicating that in addition to SCT thickness changes, CSC also involves pathological changes such as choriocapillaris injury and reduced blood flow.…”

Comparison of Chorioretinal Parameters in Diabetic Retinopathy with or without Pan-Retinal Photocoagulation Using Ultrawide-Field Swept-Source Optical Coherence Tomography Angiography

“…In this study, we quantified structural and vascular parameters in the central and peripheral retinal and choroidal layers in eyes diagnosed with severe NPDR or PDR with and without PRP using ultrawide-field SS-OCTA, which made it possible to obtain an image with a 24 mm × 20 mm rectangular scan, while still maintaining a lateral resolution of 10 µm [12][13][14][15]. No significant difference was found in retinal thickness and vessel density of SCP or DCP between eyes with and without PRP.…”

Quantitative assessment of intervortex anastomosis in central serous chorioretinopathy and fellow eyes: Does the size of anastomotic vessels matter for the diagnosis?

“…As we all know, even the fellow eyes of the CSC cases have thicker choroid [16], dilated choroidal vessels and hyperreflective areas identified on swept source OCTA [17]. Therefore, determining whether there is intervortex anastomosis in the fellow eyes will strengthen the presence of intervortex anastomosis as a common feature of the pachychoroid spectrum.…”