Comparison of survival between right‐sided and left‐sided colon cancer in different situations

Abstract

Mountain of studies has showed that right‐sided colon cancer (RSCC) and left‐sided colon cancer (LSCC) have different clinical presentation and biologic features and should be considered as two distinct disease entities. The survival difference between RSCC and LSCC remains controversial. Using Surveillance, Epidemiology, and End Results (SEER) database, we identified colon adenocarcinoma patients from 2004 to 2013. The 5‐year cause‐specific survival (CSS) was our primary endpoint. All statistical analyses were performed using the Intercooled Stata 13.0. All statistical tests were two‐sided. The study included 95,847 (58.72%) RSCC and 67,385 (41.28%) LSCC patients. RSCC patients were older, more often females, more Caucasian, more unmarried, more advanced T and N stage, larger tumor sizes, and more poorly differentiated tumor, while LSCC patients had more stage IV diseases. Location was an independent prognostic factor in the multivariable analysis. Compared with RSCC patients, the hazard ratio for LSCC was 0.87, 95% CI: 0.85–0.89 P < 0.001. There was no survival difference between RSCC and LSCC in the following situations: older than 68 years old, T3–4, N0, poorly differentiated, and undifferentiated diseases. We firstly reported that RSCC patients had a better prognosis than LSCC in mucinous adenocarcinoma/signet ring cell carcinoma patients. RSCC patients also had a better prognosis than LSCC in stage II disease. There is a need for further subdivisions when analyzing the survival difference between RSCC and LSCC patients. RSCC had lower mortality rate than LSCC in stage II disease and mucinous adenocarcinoma/signet ring cell carcinoma patients.

Survival of Colorectal Cancer Patients in Brunei Darussalam: Comparison between 2002-09 and 2010-17

“…The de nition of right-sided colorectal cancer (RCRC) and left-sided colorectal cancer (LCRC) varies across different studies with respect to tumors in the transverse colon (some studies consider the cecum, ascending colon, hepatic exure and transverse colon as RCRC; LCRC includes the splenic exure, descending colon, sigmoid colon and rectosigmoid cancers [69][70][71] ) whereas other studies only include the proximal two-thirds of the transverse colon (alongside cecum, ascending colon and hepatic exure) as RCRC, with the distal third of the transverse colon (alongside splenic exure, descending colon, sigmoid colon and rectosigmoid cancers) categorized as LCRC [72,73] . The effect of CRC tumor subsite on CRC patients' survival rate of our study differs from previous reports [74][75][76][77][78] . Majority of the patients in this study (89.2%) present with LCRC (tumour sites from splenic exure to the rectum), which tends to associate with lowered 5-year survival rates and higher risk of death.…”

Evaluation of Prognostic Factors for Survival in Transverse Colon Cancer

“…About OS, in the multivariate analysis of the whole study population, only tumor grade (HR = 5.26, 95% CI 1.98-14.01) and BRAF status (3.71, 95% CI 1.07-12.89) were independent prognostic factors. These results are supported by those published studies in which poor histological differentiation is associated, not only with advanced T stage and the presence of lymph node involvement [23], but also directly with unfavorable clinical outcome [41] and cause-specific survival [42].…”

Morphology and Molecular Features of Rare Colorectal Carcinoma Histotypes

“…UCs occur throughout the colon-rectum but they are more frequently detected in the right colon [104].…”

“…UCs are aggressive tumors, showing a low 5-year cancer specific survival [104]. In the setting of metastatic disease patients with UCs also have a worse prognosis [105].…”