Comparison of sublingual vs. intramuscular administration of vitamin B12 for the treatment of patients with vitamin B12 deficiency

Bensky, Merav Jacobson; Ayalon-Dangur, Irit; Ayalon-Dangur, Roi; Naamany, Eviatar; Gafter‐Gvili, Anat; Koren, Gideon; Shiber, Shachaf

doi:10.1007/s13346-018-00613-y

Cited by 33 publications

(31 citation statements)

References 17 publications

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“…We also believe that it improves patients comfort and increases compliance, as it is a non-invasive, more comfortable than intramuscular method of vitamin supplementation. A recent study by Bensky et al which compared sublingual with intramuscular method of vitamin B 12 supplementation in deficient patients concluded that sublingual application is sufficient or even superior to the latter [27]. Other routes of vitamin [28].…”

Section: Discussionmentioning

confidence: 99%

Nutritional Deficiencies in Patients after Roux-en-Y Gastric Bypass and Sleeve Gastrectomy during 12-Month Follow-Up

et al. 2019

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Introduction Roux-en-Y gastric bypass (RYGB) and laparoscopic sleeve gastrectomy (LSG) are the two most frequently performed bariatric operations. These two types of metabolic surgery alter the anatomy and function of digestive tract producing significant weight loss in morbidly obese patients but may lead to malnutrition. Aim Analysis of incidence and severity of malnutrition after bariatric surgery in patients submitted to RYGB or LSG during 12 months of follow-up. Material and Methods Retrospective study of 98 patients after RYGB (n = 47) or LSG (n = 51) assessed for nutritional deficiencies during 12 months after surgery was conducted. The differences in body mass index (BMI) and blood tests including erythrocytes, haemoglobin, total protein, albumin, iron, ferritin, transferrin, vitamin B12, folic acid, calcium and phosphorus concentrations were compared between groups before the operations and at 1 and 12 months. Results Nutritional deficiencies were common before surgery with prevalence up to 19.6% for albumin in the LSG group. Median preoperative BMI levels and albumin concentrations were higher in the RYGB group compared to the LSG group, but there was no difference in percent excess weight loss (%EWL) at 1 and 12 months between LSG and RYGB. One month after LSG erythrocyte count, haemoglobin, iron, ferritin and transferrin levels were significantly higher than in the RYGB group. These differences subsided at 12 months. At 12 months, only the prevalence of vitamin B 12 deficiency was significantly higher in the RYGB group. Conclusion Both RYGB and LSG lead to nutritional deficiencies despite different properties of operations and similar %EWL during follow-up.

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Section: Discussionmentioning

confidence: 99%

Nutritional Deficiencies in Patients after Roux-en-Y Gastric Bypass and Sleeve Gastrectomy during 12-Month Follow-Up

et al. 2019

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“…The post-treatment values significantly differed between the two groups (p < 0.001). The authors concluded that SL route should be the firstline choice of treatment in patients with VB12 deficiency 13 . Sharabi et al compared SL and oral routes in a randomized prospective study of 30 adults with VB12 deficiency.…”

Section: Discussionmentioning

confidence: 99%

“…Approximately 60% of the absorption of dietary VB12 occurs through this biochemical mechanism 12 . Through the second pathway, dietary VB12 gets absorbed by simple diffusion (without binding to IF) along the entire intestine or it gets directly absorbed by sublingual (SL) capillaries 13 . Therefore, SL route for treating VB12 deficiency has several advantages, including potentially good adherence to treatment, safety, and low cost 1 .…”

Section: Introductionmentioning

confidence: 99%

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Comparison of Sublingual and Intramuscular Administration of Vitamin B12 for the Treatment of Vitamin B12 Deficiency in Children

Tuğba-Kartal

Çağla-Mutlu²

2021

RIC

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Background: In most countries, contrary to some disadvantages, such as pain, relatively higher cost, and poor adherence to treatment, intramuscular (IM) route is still the primary treatment method for Vitamin B12 (VB12) deficiency. In recent years, because of these difficulties, new treatment methods are being sought for VB12 deficiency. Objectives: We aimed to compare sublingual (SL) and IM routes of VB12 administration in children with VB12 deficiency and to compare the efficacy of methylcobalamin and cyanocobalamin therapy in these children. Methods: This retrospective study comprised 129 patients with VB12 deficiency (serum Vitamin 12 level ≤ 200 pg/mL) aged 5-18 years. Based on the formulations of Vitamin 12, we divided the patients into three treatment groups as IM cyanocobalamin, SL cyanocobalamin, and SL methylcobalamin. Results: After Vitamin 12 therapy, serum Vitamin 12 levels increased significantly in all patients, and there was a statistically significant difference between the treatment groups (p < 0.05). Conclusions: SL cyanocobalamin and methylcobalamin were found as effective as IM cyanocobalamin for children with Vitamin 12 deficiency in correcting serum Vitamin 12 level and hematologic abnormalities.

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“…Strong et al demonstrated that sublingual treatment of diabetic patients with decreased serum vitamin B12 concentration is as effective as intramuscular injection in correcting a low vitamin B12 status over 6 months [68]. A recent retrospective study carried out by Bensky et al on more than 4800 patients evaluated the differences between vitamin B12 serum levels after sublingual treatment and intramuscular injections; this study demonstrated that sublingual and intramuscular routes are equally efficient in raising vitamin B12 levels, underlining an even superior efficacy of the sublingual route, which brought to an increase by 193% [69].…”

Section: Cobalamin (Vitamin B12)mentioning

confidence: 99%

Vitamin B Supplementation and Nutritional Intake of Methyl Donors in Patients with Chronic Kidney Disease: A Critical Review of the Impact on Epigenetic Machinery

Cappuccilli

Bergamini²,

Giacomelli³

et al. 2020

Nutrients

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Cardiovascular morbidity and mortality are several-fold higher in patients with advanced chronic kidney disease (CKD) and end-stage renal disease (ESRD) than in the general population. Hyperhomocysteinemia has undoubtedly a central role in such a prominent cardiovascular burden. The levels of homocysteine are regulated by methyl donors (folate, methionine, choline, betaine), and cofactors (vitamin B6, vitamin B12,). Uremia-induced hyperhomocysteinemia has as its main targets DNA methyltransferases, and this leads to an altered epigenetic control of genes regulated through methylation. In renal patients, the epigenetic landscape is strictly correlated with the uremic phenotype and dependent on dietary intake of micronutrients, inflammation, gut microbiome, inflammatory status, oxidative stress, and lifestyle habits. All these factors are key contributors in methylome maintenance and in the modulation of gene transcription through DNA hypo- or hypermethylation in CKD. This is an overview of the epigenetic changes related to DNA methylation in patients with advanced CKD and ESRD. We explored the currently available data on the molecular dysregulations resulting from altered gene expression in uremia. Special attention was paid to the efficacy of B-vitamins supplementation and dietary intake of methyl donors on homocysteine lowering and cardiovascular protection.

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Comparison of sublingual vs. intramuscular administration of vitamin B12 for the treatment of patients with vitamin B12 deficiency

Cited by 33 publications

References 17 publications

Nutritional Deficiencies in Patients after Roux-en-Y Gastric Bypass and Sleeve Gastrectomy during 12-Month Follow-Up

Nutritional Deficiencies in Patients after Roux-en-Y Gastric Bypass and Sleeve Gastrectomy during 12-Month Follow-Up

Comparison of Sublingual and Intramuscular Administration of Vitamin B12 for the Treatment of Vitamin B12 Deficiency in Children

Vitamin B Supplementation and Nutritional Intake of Methyl Donors in Patients with Chronic Kidney Disease: A Critical Review of the Impact on Epigenetic Machinery

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