Comparison of subcutaneous versus intranasal immunization of male koalas (Phascolarctos cinereus) for induction of mucosal and systemic immunity against Chlamydia pecorum

Waugh, Courtney; Andrew, Dean; Rawlinson, Galit; Brumm, Jacqui; Nilsson, Kjell; Beagley, Kenneth W.

doi:10.1016/j.vaccine.2014.12.052

Cited by 20 publications

(19 citation statements)

References 34 publications

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“…Although a report by Waugh et al. () has made preliminary observations on a mucosal vaccination route in koalas, it did not demonstrate a protective immune response.…”

Section: Resistance and Tolerance At Individual And Population Levelsmentioning

confidence: 89%

“…A recent study by Stary et al (2015) highlights the difficulties involved in developing a vaccine for chlamydia; the authors argue earlier chlamydial vaccines for human and other animal use have been at best ineffective and worse sometimes harmful, because vaccines have been developed using: (1) wrong antigen, (2) wrong adjuvant, and (3) wrong mode of administration (nonmucosal). Although a report by Waugh et al (2015) has made preliminary observations on a mucosal vaccination route in koalas, it did not demonstrate a protective immune response.…”

Section: Vaccination or Treatmentmentioning

confidence: 93%

“…But, first, there needs to be a demonstrably effective vaccine. While progress has undoubtedly been made toward a vaccine against chlamydia in koalas (Waugh et al, 2015(Waugh et al, , 2016, the effectiveness of this vaccine has not yet been established with double blind challenge trials. It is salutary to note here that despite more than 50 years research, a safe and effective vaccine against human strains of chlamydia has yet to be developed (Mabey, Hu, Bailey, Burton, & Holland, 2014;Stary et al, 2015).…”

Section: Filling Research Gapsmentioning

confidence: 99%

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Assessing the significance of endemic disease in conservation—koalas, chlamydia, and koala retrovirus as a case study

McCallum

Kerlin

Ellis

et al. 2017

CONSERVATION LETTERS

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It can be difficult to establish the conservation significance of endemic infectious diseases-those that are well established in a population-in contrast with infectious diseases that are still invading. This difficulty can have important implications for designing policy to address species declines. The infectious diseases of koalas provide an ideal case study to examine issues involved in identifying the role of endemic disease in conservation biology. Koala populations are in decline, amidst claims for many years that infectious diseases, particularly those with chlamydial etiology, play a key role in this loss. However, weak associations between prevalence of infection, clinical signs of disease, and population decline mean that it remains unclear whether infectious disease is a primary driver of koala population decline. There are multiple causes of koala decline including drought, habitat destruction, and disease. Welldesigned experiments, linked to appropriate models, are necessary to determine the true role of infectious disease in the current koala population declines and whether a focus on disease is likely to be a feasible, let alone the most cost-effective, means of preventing further declines.

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“…Although a report by Waugh et al. () has made preliminary observations on a mucosal vaccination route in koalas, it did not demonstrate a protective immune response.…”

Section: Resistance and Tolerance At Individual And Population Levelsmentioning

confidence: 89%

Section: Vaccination or Treatmentmentioning

confidence: 93%

Section: Filling Research Gapsmentioning

confidence: 99%

See 1 more Smart Citation

Assessing the significance of endemic disease in conservation—koalas, chlamydia, and koala retrovirus as a case study

McCallum

Kerlin

Ellis

et al. 2017

CONSERVATION LETTERS

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“…Recently, C. pneumoniae has been identified as a zoonotic pathogen, and it can infect a wide range of host species, such as the koala, frogs, and reptiles (Roulis et al 2013; Waugh et al 2015). The mouse model is used extensively in the investigation of a possible causal link between respiratory Chlamydia pneumoniae infection and asthma, COPD, and atherosclerosis and for the evaluation of immunopathogenic mechanisms (Campbell et al 2005a; Campbell and Kuo 1999; Chen et al 2010a; Zafiratos et al 2015).…”

Section: Animal Models Of Chlamydial Pathogenesismentioning

confidence: 99%

“…The mouse model is used extensively in the investigation of a possible causal link between respiratory Chlamydia pneumoniae infection and asthma, COPD, and atherosclerosis and for the evaluation of immunopathogenic mechanisms (Campbell et al 2005a; Campbell and Kuo 1999; Chen et al 2010a; Zafiratos et al 2015). It also has been used to screen vaccine candidates (Waugh et al 2015). …”

Section: Animal Models Of Chlamydial Pathogenesismentioning

confidence: 99%

Immunopathogenesis of Chlamydial Infections

Murthy¹,

Li²,

Ramsey

2016

Biology of Chlamydia

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Chlamydial infections lead to a number of clinically relevant diseases and induce significant morbidity in human populations. It is generally understood that certain components of the host immune response to infection also mediate such disease pathologies. A clear understanding of pathogenic mechanisms will enable us to devise better preventive and/or intervention strategies to mitigate the morbidity caused by these infections. Over the years, numerous studies have been conducted to explore the immunopathogenic mechanisms of Chlamydia-induced diseases of the eye, reproductive tract, respiratory tract, and cardiovascular systems. In this article, we provide an overview of the diseases caused by Chlamydia, animal models used to study disease pathology, and a historical context to the efforts to understand chlamydial pathogenesis. Furthermore, we discuss recent findings regarding pathogenesis, with an emphasis on the role of the adaptive immune response in the development of chlamydial disease sequelae. Finally, we summarize the key insights obtained from studies of chlamydial pathogenesis and avenues that remain to be explored in order to inform the next steps of vaccine development against chlamydial infections.

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Koala translocations and Chlamydia : Managing risk in the effort to conserve native species

Waugh

Hanger

2016

Biological Conservation

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Comparison of subcutaneous versus intranasal immunization of male koalas (Phascolarctos cinereus) for induction of mucosal and systemic immunity against Chlamydia pecorum

Cited by 20 publications

References 34 publications

Assessing the significance of endemic disease in conservation—koalas, chlamydia, and koala retrovirus as a case study

Assessing the significance of endemic disease in conservation—koalas, chlamydia, and koala retrovirus as a case study

Immunopathogenesis of Chlamydial Infections

Koala translocations and Chlamydia : Managing risk in the effort to conserve native species

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