Comparison of Structures and Cytotoxicity of Mupirocin and Batumin Against Melanoma and Several Other Cancer Cell Lines

Abstract

Aim: To determine the computer-predicted anticancer activity of mupirocin and to compare its activities with those determined for another polyene antibiotic, batumin. Materials & methods: Molecular docking, cytotoxicity assays, cell microscopy and cell cycle progression were studied in cancer and nontumorigenic cell lines. Results & conclusion: Cytotoxicity of mupirocin against several cancerous cell lines was detected with the highest one (IC50 = 5.4 μg/ml) against melanoma cell line. The profile of cytotoxicity of mupirocin was similar to that reported for batumin. Nevertheless, the morphology of cells treated with these antibiotics and alterations in cell cycle progression suggested possible dissimilarity in their mechanisms of action. Selective cytotoxicity of mupirocin against melanoma cells potentiates further studies to discover nontoxic drugs for melanoma prevention.

In silico approaches to study the human asparagine synthetase: An insight of the interaction between the enzyme active sites and its substrates

“…Mupirocin has anti cancerous activity against the MCF-7 breast cancer cell line [ 40 ]. Like other inhibitors mupirocin was also docked with human ASNS, which showed that it binds with enzyme via hydrogen bonds (Asp261, Gly363, Glu443, Ser292, Asn478 and Trp480).…”