Comparison of starting ovarian stimulation on day 2 versus day 15 of the menstrual cycle in the same oocyte donor and pregnancy rates among the corresponding recipients of vitrified oocytes

Martínez, Francisca; Clua, Elisabet; Devesa, Marta; Rodríguez, Ignacio; Arroyo, Gemma; González, Clara; Solé, Miquel; Tur, Rosa; Coroleu, Buenaventura; Barri, Pedro N.

doi:10.1016/j.fertnstert.2014.07.741

Cited by 54 publications

(33 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…One hypothetical explanation and also a potential risk of bias is that women who initiated their stimulation in the luteal phase represent only women who are regularly cycling, whereas the cohort of women in the follicular phase could include anovulatory women whose disease state is inhibiting normal hormonal pulsatility or women with other conditions, such as polycystic ovarian syndrome, hypothalamic amenorrhea, or premature ovarian insufficiency, who are theoretically, subfertile. This bias is addressed by one of the included [29]. Although using a small sample size, there were no differences in stimulation parameters or in recipient pregnancy rates.…”

Section: Discussionmentioning

confidence: 99%

“…Only four studies reported pregnancy outcomes and none of them included women undergoing fertility preservation [27][28][29]33]. The limited duration of follow-up and the novelty of fertility preservation make data on pregnancy outcomes limited as few patients have progressed in their treatment course to be ready to attempt pregnancy.…”

Section: Discussionmentioning

confidence: 99%

“…Human chorionic gonadotropin (hCG) was the predominant medication used to induce oocyte maturation. Although four authors induced maturation with a GnRH agonist [10,[27][28][29], three authors used either hCG or GnRH agonist depending on the clinical scenario [11,30,31], and one author performed in vitro maturation following neither hCG nor a GnRH agonist [32]. All of the included studies reported the primary outcome of number of oocytes retrieved.…”

Section: Qualitative Analysismentioning

confidence: 99%

“…This difference did not reach statistical significance. Finally, Martinez et al compared the cycles of nine oocyte donors who each underwent one luteal start COS and one follicular start COS [29]. There was no difference in pregnancy rates between recipients receiving oocytes retrieved after a luteal start COS (58.3 %, 7/12) and recipients of oocytes from a COS initiated in the early follicular phase (62.5 %, 5/8).…”

Section: Qualitative Analysismentioning

confidence: 99%

“…The final quantitative meta-analysis included eight published studies, plus the primary data from Washington University for a total of 338 women [7,11,29,33,34]. Eight of the qualitative studies were excluded due to the lack of a control group or due to a sample size of only one subject [8,10,28,32,[35][36][37][38].…”

Section: Quantitative Analysismentioning

confidence: 99%

See 4 more Smart Citations

Ovarian stimulation in the luteal phase: systematic review and meta-analysis

Boots

Meister

Cooper

et al. 2016

J Assist Reprod Genet

View full text Add to dashboard Cite

Purpose The purpose of this study was to evaluate whether outcomes are different if controlled ovarian stimulation (COS) is started in the luteal phase rather than the follicular phase. Methods A systematic review and meta-analysis was performed. Sixteen studies were included in the qualitative analysis, and eight studies with a total of 338 women were included in the quantitative analysis. Results Cycles initiated in the luteal phase were slightly longer (WMD 1.1 days, 95 % CI 0.39-1.9) and utilized more total gonadotropins (WMD 817 IU, 95 % CI 489-1144). However, no differences were noted in peak estradiol levels (WMD −411 pg/ml, 95 % CI −906-84.7) or in the total number of oocytes retrieved (WMD 0.52 oocytes, 95 % CI −0.74-1.7). There were slightly more mature oocytes retrieved in the luteal phase (WMD 0.77 oocytes, 95 % CI 0.21-1.3), and fertilization rates were significantly higher (WMD 10 %, 95 % CI 0.03-0.18). While only three studies reported pregnancy outcomes, no difference was noted in the FET pregnancy rates after COS in the luteal versus follicular phase (RR 0.95, 95 % CI 0.56-1.7).A post hoc power analysis revealed that a sample of this size was sufficient to detect a clinically meaningful difference of 2 oocytes retrieved with 93 % power.Conclusion Although initiating COS in the luteal phase requires a longer stimulation and a higher dose of total gonadotropin, these differences are not clinically significant. Furthermore, COS initiated in the luteal phase does not compromise the quantity or quality of oocytes retrieved compared to outcomes of traditional stimulation in the follicular phase.

show abstract

Section: Discussionmentioning

confidence: 99%