Comparison of SSS and SRS calculated from normal databases provided by QPS and 4D-MSPECT manufacturers and from identical institutional normals

Knollmann, Daniela; Knebel, Ingrid; Koch, Karl‐Christian; Gebhard, M W; Krohn, Thomas; Buell, U.; Schaefer, Wolfgang M.

doi:10.1007/s00259-007-0600-5

Cited by 23 publications

(11 citation statements)

References 16 publications

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“…Knollmann et al13 compared summed scores using the manufacturer-based and institution-based normal database. Both QPS and 4D-MSPECT yielded higher scores when the institutional database was used as opposed to the manufacturer’s database, but the authors did not compare the characteristics and differences between the databases.…”

Section: Discussionmentioning

confidence: 99%

The importance of population-specific normal database for quantification of myocardial ischemia: comparison between Japanese 360 and 180-degree databases and a US database

Nakajima

Okuda

Kawano

et al. 2009

Journal of Nuclear Cardiology

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Objectives-We aimed to develop a Japanese normal database for specific acquisition conditions, to compare US and Japanese normal populations, and to examine effects of camera rotation angle range on the normal limits.Methods and Results-Stress-rest 99m Tc myocardial perfusion databases for 360° (Jp360) and 180° (Jp180) acquisitions were created by the working group activity of the Japanese Society of Nuclear Medicine using Japanese patients. A standard 180° database (US180) had been previously generated by the Cedars Sinai Medical Center based on American patients. Additionally, 90 Japanese patients underwent coronary arteriography and stress-rest 99m Tc perfusion study with 360°a cquisition for validation purposes, and quantitative evaluation was performed by QPS software using the above three normal database sets. Major differences between US180 and Jp360 databases were found in the apex and in the anterior wall in females and in the inferior wall in males. When the diagnostic performance was evaluated by receiver-operating characteristic analysis, area under the curve was the highest for Jp360 (0.842), followed by Jp180 (0.758) and US180 (0.728) databases (P = .019, Jp360 vs US180; P = .035, Jp360 vs Jp180). The coronary territory score at stress was highest with the Jp360 database in male patients with right coronary artery stenosis (n = 26, Jp360: 4.92 ± 4.61 [mean ± SD], Jp180: 4.23 ± 4.29, US180: 2.92 ± 3.53; P < .0001 between Jp360 and US180) and in female patients with left anterior descending artery stenosis (n = 12, Jp360: 6.33 ± 4.76, Jp180: 5.25 ± 4.83, US180: 4.50 ± 4.15; P = .0076 between Jp360 and US180).Conclusion-Because of the differences between US and Japanese normal databases, it is essential to use population-and acquisition-specific databases when using quantitative perfusion SPECT software.

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Section: Discussionmentioning

confidence: 99%

The importance of population-specific normal database for quantification of myocardial ischemia: comparison between Japanese 360 and 180-degree databases and a US database

Nakajima

Okuda

Kawano

et al. 2009

Journal of Nuclear Cardiology

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“…By comparing manufacturer databases and institutional databases, Knollmann et al found some differences in quantitative scores between software algorithms as well as between manufacturer databases [9]. The merit of an individualized database is its specificity to camera types, camera rotation ranges, orbits, multi-detector configuration, and therefore higher diagnostic performance would be expected.…”

Section: Discussionmentioning

confidence: 99%

The validity of multi-center common normal database for identifying myocardial ischemia: Japanese Society of Nuclear Medicine working group database

et al. 2009

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Purpose. The Japanese Society of Nuclear Medicine (JSNM) working group has created a myocardial perfusion imaging database applicable to standard acquisition protocol. The aim of this study is to validate the diagnostic accuracy of the common normal database compared with the expert interpretation of each institute. Methods. Five institutions participated in this study and used different acquisition settings which included 360°/180° rotation, camera configuration and camera orbits. The software and its version used in each institution also varied. The working group database was applied to detect the culprit coronary territory from a total of 166 patients with coronary artery disease (CAD) and 145 patients with low-likelihood of CAD. Results. When summed stress score ≥4 was defined as significant abnormality, overall sensitivity, specificity and accuracy of patient-based analysis were 77%, 72% and 75%, respectively, based on quantitative analysis using the common database, whereas those by institutional visual expert reading were 72%, 79% and 75%, respectively. Conclusion. The common database, which was created by a multi-center working group and separated between male/female with 180/360° acquisitions, demonstrated comparable diagnostic accuracy to expert interpretation by each institute, and it may be applicable to multi-center studies.

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“…Validated automated algorithms provide semi-quantitative assessment of myocardial perfusion and left ventricular systolic function 11. In this study we aimed to assess the correlation between homocysteine level and myocardial SPECT abnormalities in 120 patients with suspected myocardial ischaemia.…”

Section: Introductionmentioning

confidence: 99%

Association between plasma homocysteine and myocardial SPECT abnormalities in patients referred for suspected myocardial ischaemia

Ankrah¹,

Buscombe²,

Sathekge³

2012

CVJA

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BackgroundElevated plasma homocysteine level has emerged as a relatively newly recognised risk factor for coronary artery disease (CAD). However, reduction of plasma homocysteine levels in large prospective studies did not appear to reduce the risk for subsequent cardiac events. In this study, we investigated the association between plasma homocysteine levels and quantitative indices of myocardial perfusion SPECT imaging in patients referred for myocardial ischaemia.MethodsQuantitative myocardial perfusion SPECT indices were obtained for 120 patients who were recruited for the study. All patients underwent a two-day rest–stress myocardial perfusion imaging. Plasma venous sampling was done on all patients after an overnight fast. Of the 120 participants (mean age 56 years, 53% males), 33% had elevated plasma homocysteine levels. The plasma homocysteine level was then compared to the results of imaging and other known risk factors.ResultsAfter adjustment for traditional risk factors of coronary artery disease, patients with elevated homocysteine levels had a significantly higher mean summed stress score (SSS) (11.3 vs 6.9, p = 0.02) than patients with a normal homocysteine level. This was true for both single- and multivessel disease. Also, patients with elevated homocysteine levels had a higher stress end-systolic volume (SESV) (137 vs 105 ml, p = 0.03) and lower post-stress left ventricular ejection fraction (SEF) (54 vs 64%, p = 0.02). The patients with elevated plasma homocysteine levels also had a significantly lower mean body mass index (BMI) (26.6 vs 30.6 kg/m2, p = 0.002). There was a significant relationship between the total number of known risk factors in a patient with CAD and the proportion of patients presenting with elevated plasma homocysteine levels (p = 0.03). Also, the extent of infarct, as measured by the summed rest score (SRS), was more closely correlated with an elevated homocysteine level than with the degree of ischaemia.ConclusionThere was a correlation between plasma homocysteine level and the presence and extent of myocardial perfusion abnormalities in patients with established coronary artery disease, in particular those with multiple risk factors and multi-vessel infarction.

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Comparison of SSS and SRS calculated from normal databases provided by QPS and 4D-MSPECT manufacturers and from identical institutional normals

Abstract: Considerable differences between SSS/SRS obtained with QPS and 4D-MSPECT were found when using M-NDB. Even using identical patients and identical I-NDB, the algorithms still gave substantial different results.

Cited by 23 publications

References 16 publications

The importance of population-specific normal database for quantification of myocardial ischemia: comparison between Japanese 360 and 180-degree databases and a US database

The importance of population-specific normal database for quantification of myocardial ischemia: comparison between Japanese 360 and 180-degree databases and a US database

The validity of multi-center common normal database for identifying myocardial ischemia: Japanese Society of Nuclear Medicine working group database

Association between plasma homocysteine and myocardial SPECT abnormalities in patients referred for suspected myocardial ischaemia

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