Comparison of SPME and static headspace analysis of blood alcohol concentration utilizing two novel chromatographic stationary phases

Westland, Jessica; Dorman, Frank L.

doi:10.1016/j.forsciint.2013.05.007

Cited by 14 publications

(7 citation statements)

References 10 publications

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“…Ethanol is the most commonly monitored substance in routine forensic toxicological analysis, especially in cases associated with automobile fatalities, industrial accidents and other incidents such as alcohol poisoning and drug‐facilitated sexual assaults (Westland & Dorman, ). An analytical procedure using Carbowax/PDMS (65 μm) SPME fiber was developed for determination of blood ethanol concentration.…”

Section: Classification Of Microextraction Methodsmentioning

confidence: 99%

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Microextraction sample preparation techniques in forensic analytical toxicology

Concheiro

2018

Biomedical Chromatography

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Sample preparation is a critical step in forensic analytical toxicology. Different extraction techniques are employed with the goals of removing interferences from the biological samples, such as blood, tissues and hair, reducing matrix effects and concentrating the target analytes, among others. With the objective of developing faster and more ecological procedures, microextraction techniques have been expanding their applications in the recent years. This article reviews various microextraction methods, which include solid-based microextraction, such as solidphase microextraction, microextraction by packed sorbent and stir-bar sorptive extraction, and liquid-based microextraction, such as single drop/hollow fiber-based liquid-phase microextraction and dispersive liquid-liquid microextraction, as well as their applications to forensic toxicology analysis. The development trend in future microextraction sample preparation is discussed.

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Section: Classification Of Microextraction Methodsmentioning

confidence: 99%

“…An analytical procedure using Carbowax/PDMS (65 μm) SPME fiber was developed for determination of blood ethanol concentration. With the use of t ‐butanol as internal standard, a detection limit of 0.0006 g/dL was obtained (Westland & Dorman, ).…”

Section: Classification Of Microextraction Methodsmentioning

confidence: 99%

Microextraction sample preparation techniques in forensic analytical toxicology

Concheiro

2018

Biomedical Chromatography

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“…Thirty µl samples of worm homogenates were added to a 10 ml glass GC head-space sampling vial containing 100 µl of saturated NaCl and sealed with a crimpcap septum seal. Samples were heated to gaseous state and injected on to the gas chromatography system and detected with FID, as previously conducted [23]. The output was analyzed using LabSolutions chromatography analysis software and EtOH levels in samples were determined by comparison with a standard curve.…”

Section: Gas Chromatography Etoh Concentration Analysismentioning

confidence: 99%

Caenorhabditis elegans as a model system to identify therapeutics for alcohol use disorders

Katner¹,

Bredhold

Steagall³

et al. 2019

Behavioural Brain Research

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“…Due to the number of samples received, a toxicological laboratory requires a rapid and accurate analytical method for determining ethanol concentration [15]. Headspace gas chromatography with flame-ionization detection (HS-GC-FID) has become a gold standard for ethanol analysis because of ease of automation, accuracy, sensitivity, and specificity [16].…”

Section: Introductionmentioning

confidence: 99%

Validation of a method for ethanol analysis in biological and non-biological samples and its toxicological application

Kostić

Vujović

Milosavljevic

2021

Hem Ind

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A simple, cost-effective and fast headspace gas chromatography method coupled with flame ionization detection (HS-GC/FID) for determination of ethanol was developed and validated for clinical and forensic toxicology purposes. HS-GC/FID is often used for alcohol determination in different biological and non-biological samples. The calibration dependence of the method was linear in the range from 0.15 to 4.00 g dm-3 (r2=0.999) with adequate accuracy (99-106 %) and precision. The limit of detection (LOD) was 0.006 g dm-3. The method was quantitative (LOQ) above 0.020 g dm-3. The new method was successfully used for determination of ethanol in biological samples of intoxicated patients, car accidents participants, participants in criminal acts, and postmortem samples, non-biological samples such as alcoholic beverages, alcohol-based herbal preparations, cosmetic preparations, etc. This method is easy to perform, making it suitable not only for the routine applications in clinical biochemistry and forensic laboratories, but also in different fields of industry (e.g. for pharmaceutical preparations, cosmetics, dietary supplements, etc.). Some of the applications for ethanol determination in different samples related to various clinical-forensic cases are presented.

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Comparison of SPME and static headspace analysis of blood alcohol concentration utilizing two novel chromatographic stationary phases

Cited by 14 publications

References 10 publications

Microextraction sample preparation techniques in forensic analytical toxicology

Microextraction sample preparation techniques in forensic analytical toxicology

Caenorhabditis elegans as a model system to identify therapeutics for alcohol use disorders

Validation of a method for ethanol analysis in biological and non-biological samples and its toxicological application

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