Comparison of Splenic and Renal Subcapsular Islet Autografting in Dogs

Islet Cell Transplantation

“…Fourteen patients achieved an insulin inde pendence that was maintained between 10 and 1,178 days. Four common characteristics have been found to play a pivotal role in achieving insulin independence: mean preservation time of the donor pancreas of less than 8 h, transplanted islet mass of more than 6,000 Eq islet/kg body weight, liver as the site of implantation and adminis tration of antilymphocyte globulin for induction of immu nosuppression [13], Furthermore, several reports showed that intrahepatic transplantation of purified or unpurified human islets can replace the pancreatic endocrine func tion in diabetic patients without any side effects for the patients or their liver function [14][15][16][17][18], According to these data islet transplantation can be considered a poten tial alternative to vascularized pancreas transplantation in the treatment of type I diabetes. But two main ques tions remain open in this field.…”

Economic 3D-printing approach for transplantation of human stem cell-derivedβ-like cells

“…Most current clinical approaches with cadaveric islets rely on infusion into the liver, rendering them irretrievable [3][4][5][6]. Other transplantation sites used in research, such as the kidney capsule [7,8,11] or fat pad [12], are not viable for clinical transplantation. Large spaces, such as subcutaneous [13,14], intraperitoneal (IP) [9,15], or in the omentum [16], can potentially hold a sufficiently large cellembedded device to convey a positive clinical outcome while also allowing for cell retrieval.…”