Comparison of sperm viability with seminal plasma metal levels

Dawson, Earl B.; Ritter, Sherry; Harris, William A.; Evans, Douglas R.; Powell, Leslie C.

doi:10.1007/bf02783337

Cited by 51 publications

(31 citation statements)

References 10 publications

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“…It has also been reported that aluminum chloride decreases production of testicular testosterone in mice [10]. Elevated aluminum levels in spermatozoa and seminal plasma were previously shown to be correlated with decreased sperm motility [6]; however in a later study, NO levels were also shown to be increased in the related tissue of mice [10]. Interstitial macrophages in the testis are an important source of nitric oxide produced by iNOS.…”

Section: Discussionmentioning

confidence: 88%

Expression of Constitutive Endothelial, Neuronal and Inducible Nitric Oxide Synthase in the Testis and Epididymis of Horse

Ha¹,

Kim

Shin

2004

The Journal of Veterinary Medical Science

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ABSTRACT. The expression of three isoforms of nitric oxide synthase (NOS) were examined in the testis and epididymis of a thoroughbred horse. Immunohistochemical studies demonstrated the presence of eNOS immunostaining in some germ cells in the seminiferous tubules and in vascular endothelial cells in the interstitial tissues. Interstitial cells, most likely Leydig cells, were also intensel y immunopositive for eNOS. The pattern of immunostaining for nNOS was similar to that for eNOS in the testis. Weak expression of iNOS was detec ted in the seminiferous tubules of the testis, but intense expression was found in interstitial cells. Inducible NOS was also stron gly detected in stereocilia, sperm, epithelium and connective tissue of the epididymis of normal horses. These findings suggest that three isoforms of NOS are expressed in the testis and epididymis of horse and that they play important roles in the biology of interstitial cells that produce testosterone, as well as in spermatogenesis in the seminiferous tubules. KEY WORDS: epididymis, equine, nitric oxide synthase, testis.

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Section: Discussionmentioning

confidence: 88%

Expression of Constitutive Endothelial, Neuronal and Inducible Nitric Oxide Synthase in the Testis and Epididymis of Horse

Ha¹,

Kim

Shin

2004

The Journal of Veterinary Medical Science

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“…In humans, sperm cell motility was enhanced by 0.2−1.0mM of Mg 2+ , while higher concentration led to the same motility compared to control levels (Magnus et al, 1990). In sea urchin, as well as in humans, Mg 2+ has been found to increase viability of spermatozoa in dose-dependent manner (Dawson et al, 1998). Enhancing effect of Mg 2+ ions of seminal plasma on motility of spermatozoa was also found, among others, in fish (Hajirezaee et al, 2010;Bozkurt et al, 2011).…”

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confidence: 71%

Relationship of ejaculate quality and selected biochemical parameters of blood in cockerels of three laying lines

Jarinkovičová¹,

Máchal²,

Máchal³

et al. 2012

Czech J. Anim. Sci.

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In domestic fowl (Gallus gallus f. domestica), monitoring of both quantitative and qualitative parameters of ejaculates is an indispensable precondition of successful artificial insemination; on the basis of the obtained results it is then possible to select the individuals that produce sufficient amounts AbstRAct: Ejaculates and blood plasma were sampled from cocks of three laying lines: Barred Plymouth Rock (BPR), Sussex Light (SU), and Rhode Island Red (RIR). Ejaculates and blood plasma were sampled four times during the laying period of hens. The following ejaculate parameters were determined: sperm motility, concentrations of sperm cells, ejaculate volume. Sperm morphology was examined. In the blood samples, concentrations of glucose, cholesterol, creatinine, calcium, phosphorus, and magnesium were analysed. The motility of spermatozoa of the cocks was 47.0% (BPR), 47.7% (RIR), and 48.3% (SU), respectively. The highest volume of ejaculate was found in BPR line (0.66 cm 3 ), the lowest one in SU line (0.46 cm 3 , P ≤ 0.01); the highest sperm concentration was in SU line (2.46 × 10 6 /mm 3 ), the lowest one in RIR line (1.96 × 10 6 /mm 3 , P ≤ 0.01). The number of morphologically abnormal sperm cells was similar in all lines − 47.0% BPR, 47.7% RIR, and 48.3% SU, respectively. In general, the occurrence of defective spermatozoa was high in all three lines; the most frequent were tail defects (from 20.3 to 29.7%), while sperm cells with developmental anomalies were less frequent (only 0.3 to 0.4%). Calculated phenotypic correlation between sperm motility on the one hand and the occurrence of defective sperm cells on the other was negative (r p = −0.28, P ≤ 0.01), as well as the correlation between sperm motility and sperm numbers, and between sperm motility and ejaculate volume (r p = −0.28, P ≤ 0.01 and r p = −0.31, P ≤ 0.01, respectively). Negative correlations were found between the level of magnesium in blood plasma and numbers of morphologically defective spermatozoa in the ejaculate, defective heads and defective connecting pieces (r p = −0.33, P ≤ 0.01; r p = −0.23, P ≤ 0.05; and r p = −0.26, P ≤ 0.05). Level of magnesium was positively correlated to sperm motility (r p = 0.26, P ≤ 0.05). However, positive correlations existed between concentration of glucose in blood plasma of cocks and numbers of morphologically defective spermatozoa in sampled ejaculates (r p = 0.27, P ≤ 0.01). Our finding is in accordance with the results found in mammals and other animals, and it shows an important role of magnesium as a key contributor to the quality of ejaculate in aviary species, in our case in laying lines of domestic fowl (Gallus domesticus).

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“…Over the last years, concerns have increased about Al exposure and its relationship to reproductive health [9][10][11]. The decline of sperm quality and increases in infertility have been observed over recent decades [12][13][14], which suggests the involvement of environmental contributors to this phenomenon.…”

Section: Introductionmentioning

confidence: 99%

Aluminum exposure for 60 days at human dietary levels impairs spermatogenesis and sperm quality in rats

Martinez

Escobar

Uranga

et al. 2017

Reproductive Toxicology

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Highlights Our study shows that 60-day exposure to low doses of aluminum, which aimed to mimic human exposure to dietary aluminum is able to impair male reproductive health. Strikingly, the reproductive impairment was, sometimes, less-marked at the higher dose of Al, raising concerns regard to safe values for human exposure to aluminum. AbstractConcerns about environmental aluminum (Al) and reproductive health have been raised. We investigated the effects of Al exposure at a human relevant dietary level and a high level exposure to Al. Experiment 1 (Lower level) rats were treated orally for 60 days: a) controls -ultrapure water; b) aluminum at 1.5 mg/kg bw/day and c) aluminum at 8.3 mg/kg bw/day. Experiment 2 (High level) rats were treated for 42 days: a) controls -ultrapure water; b) aluminum at 100 mg/kg bw/day. Al decreased sperm count, daily sperm production, sperm motility, normal morphological sperm, impaired testis histology; increased oxidative stress in reproductive organs and inflammation in testis. Our study shows the specific presence of Al in the germinative cells and, that low concentrations of Al in testes (3.35 μg/g) are sufficient to impair spermatogenesis and sperm quality. Our findings provide a better understanding of the reproductive health risk of Al.

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Comparison of sperm viability with seminal plasma metal levels

Cited by 51 publications

References 10 publications

Expression of Constitutive Endothelial, Neuronal and Inducible Nitric Oxide Synthase in the Testis and Epididymis of Horse

Expression of Constitutive Endothelial, Neuronal and Inducible Nitric Oxide Synthase in the Testis and Epididymis of Horse

Relationship of ejaculate quality and selected biochemical parameters of blood in cockerels of three laying lines

Aluminum exposure for 60 days at human dietary levels impairs spermatogenesis and sperm quality in rats

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