Comparison of Speed of Sound Measures Assessed by Multisite Quantitative Ultrasound to Bone Mineral Density Measures Assessed by Dual-Energy X-Ray Absorptiometry in a Large Canadian Cohort: the Canadian Multicentre Osteoporosis Study (CaMos)

Olszynski, Wojciech P.; Adachi, J.D.; Hanley, David A.; Davison, K. Shawn; Brown, Jacques P.

doi:10.1016/j.jocd.2015.04.004

Cited by 17 publications

(9 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The system is equipped with a convex 3.5 MHz transducer, which simultaneously detects B-mode ultrasound signals and unprocessed radiofrequency signals. Those which are analyzed by the machine's statistical algorithm (EchoStudio ® ; Echolight SRL) for each region of interest (ROI), taking into account the patient's ethnicity, age, sex and BMI and comparing them to a database of ~10,000 subjects (18,20,24–26). The ROI for each patient included the usual sites for the diagnosis of osteoporosis: The lumbar spine (L1-L4 vertebrae approached from the abdomen) and the femoral necks.…”

Section: Methodsmentioning

confidence: 99%

A novel quantitative method for estimating bone mineral density using B‑mode ultrasound and radiofrequency signals‑a pilot study on patients with rheumatoid arthritis

et al. 2019

View full text Add to dashboard Cite

The objective of the present study was to evaluate whether an innovative quantitative ultrasound (QUS) technique, Radiofrequency Echographic Multi Spectromety, which combines B-mode ultrasound and radiofrequency signals, is reliable in typical Romanian patients compared to previous results obtained using dual-energy X-ray absorptiometry (DXA). The study prospectively included previously unscreened post-menopausal females with rheumatoid arthritis (RA) and age-matched healthy controls. Bone mineral density (BMD) measurements were performed with an EchoS machine (Echolight ® ), which combines B-mode ultrasound and radiofrequency signals. The study included 106 RA patients, with a median disease duration of 3.2 (0.5–22) years and 119 controls. RA patients had a significantly lower body weight, body mass index (BMI) and basal metabolic rate (BMR) than the controls, while the prevalence of obesity and body fat differed insignificantly. RA patients had a significantly lower spine and hip BMD, higher fracture risk and higher prevalence of osteoporosis. Compared to RA patients without osteoporosis, those with osteoporosis were significantly older and had a longer menopause duration, but they had a significantly lower BMI, body fat, BMR and prevalence of obesity. Among the controls and RA patients, the median spine and hip BMD became significantly higher as the BMI increased from underweight to obesity. In conclusion, osteoporosis is prevalent among RA patients, as a part of a complex transformation of body mass composition, involving BMI and fat mass. The novel QUS scanning technique was able to replicate the results of the established DXA measurement of BMD and is potentially suitable for screening wide populations for osteoporosis.

show abstract

Section: Methodsmentioning

confidence: 99%

A novel quantitative method for estimating bone mineral density using B‑mode ultrasound and radiofrequency signals‑a pilot study on patients with rheumatoid arthritis

et al. 2019

View full text Add to dashboard Cite

show abstract

“…However, the relative contributions of structural and material properties to the measured sound propagation characteristics remain challenging to discern [46]. QUS devices are portable, use non-ionizing radiation, and are increasingly applied in clinical studies [48,49] at distal sites of the skeleton (e.g., radius and tibia), which represent the same imaging target of HR-pQCT. With this respect, 3D descriptions of the local cortical porosity obtained from HR-pQCT could be combined with site-matched experimental measurements and numerical simulations of ultrasound propagation in long bones, to help elucidating the interplay between ultrasound and the cortical microstructure.…”

Section: A Bmd-based Measurement Of Ct Po Localmentioning

confidence: 99%

BMD-based assessment of local porosity in human femoral cortical bone

Iori

Heyer

Kilappa³

et al. 2018

Bone

View full text Add to dashboard Cite

Cortical pores are determinants of the elastic properties and of the ultimate strength of bone tissue. An increase of the overall cortical porosity (Ct.Po) as well as the local coalescence of large pores cause an impairment of the mechanical competence of bone. Therefore, Ct.Po represents a relevant target for identifying patients with high fracture risk. However, given their small size, the in vivo imaging of cortical pores remains challenging. The advent of modern high-resolution peripheral quantitative computed tomography (HR-pQCT) triggered new methods for the clinical assessment of Ct.Po at the peripheral skeleton, either by pore segmentation or by exploiting local bone mineral density (BMD). In this work, we compared BMD-based Ct.Po estimates with high-resolution reference values measured by scanning acoustic microscopy. A calibration rule to estimate local Ct.Po from BMD as assessed by HR-pQCT was derived experimentally. Within areas of interest smaller than 0.5 mm, our model was able to estimate the local Ct.Po with an error of 3.4%. The incorporation of the BMD inhomogeneity and of one parameter from the BMD distribution of the entire scan volume led to a relative reduction of the estimate error of 30%, if compared to an estimate based on the average BMD. When applied to the assessment of Ct.Po within entire cortical bone cross-sections, the proposed BMD-based method had better accuracy than measurements performed with a conventional threshold-based approach.

show abstract

“…Studies investigating the association between the measurements of DXA and QUS revealed inconsistent results. While a number of studies showed a significant positive correlation between DXA and QUS ( Van Rijn et al, 2000 ; Di Mase et al, 2012 ; Falcini et al, 2000 ; Gonçalves et al, 2014 ; Hartman et al, 2004a ; Pluskiewicz et al, 2002 ; Sani et al, 2011 ; Sundberg et al, 1998 ; Xu et al, 2014 ; Bąk-Drabik et al, 2016 ; Catalano et al, 2017 ; Olszynski et al, 2016 ; Zuckerman-Levin et al, 2007 ; Mora et al, 2009 ; Weeks et al, 2016 ; Halaba et al, 2005 ; Catalano et al, 2013 ), others found a discrepancy between the measurements of the two methods ( Gianni et al, 2008 ; Halaba et al, 2005 ; Chong et al, 2015 ; Christoforidis et al, 2010 ; Christoforidis et al, 2011 ; Hartman et al, 2004b ; Williams et al, 2012 ; Alwis et al, 2010 ). This could be a result of the different QUS measurement sites or different patient categories investigated.…”

Section: Introductionmentioning

confidence: 99%

“…This could be a result of the different QUS measurement sites or different patient categories investigated. Only a limited number of studies used the phalangeal QUS ( Di Mase et al, 2012 ; Gonçalves et al, 2014 ; Pluskiewicz et al, 2002 ; Bąk-Drabik et al, 2016 ; Catalano et al, 2017 ; Olszynski et al, 2016 ; Halaba et al, 2005 ; Catalano et al, 2013 ) and only one study looked at the specific group of former preterm born children ( Gianni et al, 2008 ).…”

Section: Introductionmentioning

confidence: 99%

Evaluation of bone mineralization in former preterm born children: Phalangeal quantitative ultrasound cannot replace dual-energy X-ray absorptiometry

et al. 2018

View full text Add to dashboard Cite

BackgroundPreterm infants are at risk of impaired bone health in later life. Dual-energy X-ray absorptiometry-scan (DXA) is the gold standard to determine bone mineralization. Phalangeal quantitative ultrasound (pQUS) is an alternative technique that is inexpensive, easy to use and radiation-free. The aim of this study was to investigate whether both techniques reveal equivalent results.Materials and methodsSixty former preterm infants (31 boys; 29 girls) received a DXA and pQUS at age 9 to 10 years. DXA measured bone mineral content (BMC) and bone mineral density (BMD) for total body and lumbar spine (L1-4), while pQUS measured the amplitude dependent speed of sound (AD-SoS) and bone transit time (BTT) at metacarpals II-IV providing continuous values and Z-scores based on age and sex. Four statistical methods evaluated the association between both techniques: Pearson's correlation coefficients, partial correlation coefficients adjusted for gestational age, height and BMI, Bland-Altman analysis and cross tabulation.ResultsBoth techniques showed a statistically significant weak correlation for continuous values as well as Z-scores (0.291–0.462, p < 0.05). Boys had significant and relatively high correlations (0.468–0.585, p < 0.05). In comparison, the correlations for girls were not significant. Correlation coefficients further decreased while calculating the partial correlations. The Bland-Altman plots showed poor agreement. Sensitivity ranged from 33% to 92% and specificity from 16% to 68%. Positive and negative predictive values ranged from 4% to 38% and 82% to 97%, respectively.ConclusionsWe found statistically significant weak correlations and poor agreement between DXA and pQUS measurements. DXA is not equivalent to pQUS and therefore not replaceable by this technique in former preterm born children at the age of 9 to 10 years.

show abstract

Comparison of Speed of Sound Measures Assessed by Multisite Quantitative Ultrasound to Bone Mineral Density Measures Assessed by Dual-Energy X-Ray Absorptiometry in a Large Canadian Cohort: the Canadian Multicentre Osteoporosis Study (CaMos)

Cited by 17 publications

References 27 publications

A novel quantitative method for estimating bone mineral density using B‑mode ultrasound and radiofrequency signals‑a pilot study on patients with rheumatoid arthritis

A novel quantitative method for estimating bone mineral density using B‑mode ultrasound and radiofrequency signals‑a pilot study on patients with rheumatoid arthritis

BMD-based assessment of local porosity in human femoral cortical bone

Evaluation of bone mineralization in former preterm born children: Phalangeal quantitative ultrasound cannot replace dual-energy X-ray absorptiometry

Contact Info

Product

Resources

About