Comparison of Spectralis-OCT, GDxVCC and GDxECC in assessing retinal nerve fiber layer (RNFL) in glaucomatous patients

Schallenberg, Maurice; Dekowski, Dirk; Selbach, J. Michael; Steuhl, Klaus‐Peter

doi:10.1007/s00417-012-2219-x

Cited by 11 publications

(15 citation statements)

References 37 publications

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“…Recently, we were able to demonstrate that an undifferentiated comparison of RNFL thickness assessment between GDx VCC, GDx Pro and Spectralis OCT is not feasible. The measurements with SD OCTs are generally higher than with GDx VCC and GDx Pro, the reasons being physical differences of the imaging methods [ 8 ] but also software dependent. In the standard clinical glaucoma RNFL protocols and printouts of almost all OCT devices, blood vessels are not extracted from RNFL measurements [ 9 ].…”

Section: Discussionmentioning

confidence: 99%

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Optical Coherence Tomography, Scanning Laser Polarimetry and Confocal Scanning Laser Ophthalmoscopy in Retinal Nerve Fiber Layer Measurements of Glaucoma Patients

Fanihagh¹,

Anastassiou²,

Schallenberg³

et al. 2015

TOOPHTJ

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Purpose: To determine the correlations and strength of association between different imaging systems in analyzing the retinal nerve fiber layer (RNFL) of glaucoma patients: optical coherence tomography (OCT), scanning laser polarimetry (SLP) and confocal scanning laser ophthalmoscopy (CSLO).Materials and Methodology: 114 eyes of patients with moderate open angle glaucoma underwent spectral domain OCT (Topcon SD-OCT 2000 and Zeiss Cirrus HD-OCT), SLP (GDx VCC and GDx Pro) and CSLO (Heidelberg Retina Tomograph, HRT 3). Correlation coefficients were calculated between the structural parameters yielded by these examinations. The quantitative relationship between the measured RNFL thickness globally and for the four regions (superior, inferior, nasal, temporal) were evaluated with different regression models for all used imaging systems.Results: The strongest correlation of RNFL measurements was found between devices using the same technology like GDx VCC and GDx Pro as well as Topcon OCT and Cirrus OCT. In glaucoma patients, the strongest associations (R²) were found between RNFL measurements of the two optical coherence tomography devices Topcon OCT and Cirrus OCT (R² = 0.513) and between GDx VCC and GDx Pro (R² = 0.451). The results of the OCTs and GDX Pro also had a strong quantitative relationship (Topcon OCT R² = 0.339 and Cirrus OCT R² = 0.347). GDx VCC and the OCTs showed a mild to moderate association (Topcon OCT R² = 0.207 and Cirrus OCT R² = 0.258). The confocal scanning laser ophthalmoscopy (HRT 3) had the lowest association to all other devices (Topcon OCT R² = 0.254, Cirrus OCT R² = 0.158, GDx Pro R² = 0.086 and GDx VCC R² = 0.1).Conclusion: The measurements of the RNFL in glaucoma patients reveal a high correlation of OCT and GDx devices because OCTs can measure all major retinal layers and SLP can detect nerve fibers allowing a comparison between the results of this devices. However, CSLO by means of HRT topography can only measure height values of the retinal surface but it cannot distinguish between different retinal layers.This may explain the rather poor correlations and associations between CSLO measurements and those of all other imaging devices which makes it difficult to compare HRT 3 nerve fiber data.These correlations are important in clinical routine especially when different techniques are used in the follow-up of glaucoma patients.

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Section: Discussionmentioning

confidence: 99%

“…The atypical retardation pattern (ARP) has a major impact on the RNFL thickness results of GDx devices and it is significantly lower in GDx Pro than in GDx VCC. This must be taken into consideration when evaluting RNFL thickness measurements and may be an explanation for the higher correlations of GDx Pro with SD OCT data [ 8 ].…”

Section: Discussionmentioning

confidence: 99%

Optical Coherence Tomography, Scanning Laser Polarimetry and Confocal Scanning Laser Ophthalmoscopy in Retinal Nerve Fiber Layer Measurements of Glaucoma Patients

Fanihagh¹,

Anastassiou²,

Schallenberg³

et al. 2015

TOOPHTJ

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“…Schallenberg et al . [ 75 ] used GDx-VCC, GDx-ECC, and Spectralis-OCT to study RNFL measurements in 92 eyes of 92 glaucoma patients with various amount of glaucomatous damage and found that they cannot be directly compared because of differences in method of the devices.…”

Section: Comparison With Other Diagnostic Modalitiesmentioning

confidence: 99%

Scanning laser polarimetry in glaucoma

Dada

Sharma

Angmo

et al. 2014

Indian J Ophthalmol

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Glaucoma is an acquired progressive optic neuropathy which is characterized by changes in the optic nerve head and retinal nerve fiber layer (RNFL). White-on-white perimetry is the gold standard for the diagnosis of glaucoma. However, it can detect defects in the visual field only after the loss of as many as 40% of the ganglion cells. Hence, the measurement of RNFL thickness has come up. Optical coherence tomography and scanning laser polarimetry (SLP) are the techniques that utilize the evaluation of RNFL for the evaluation of glaucoma. SLP provides RNFL thickness measurements based upon the birefringence of the retinal ganglion cell axons. We have reviewed the published literature on the use of SLP in glaucoma. This review elucidates the technological principles, recent developments and the role of SLP in the diagnosis and monitoring of glaucomatous optic neuropathy, in the light of scientific evidence so far.

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“…The OCT device used in our study, Spectralis HRA+OCT, is the only device has a long wavelength of 870 nm allowing a better penetration through existing cataract. And together with other enhancement such as a coefficient variance of less than 1.0, a faster scanning speed of 40000 A scans/sec, better axial resolution of 7 um and an eye-tracking system to account for eye movement, this probably explain why the RNFL thickness measurements by Spectalis HRA+OCT is less susceptible to the effect of media opacity as compared to previous literature using other OCT devices [24,25].…”

Section: Effect Of Cataract Extraction On Rnfl Thickness Measured By Octmentioning

confidence: 89%

Effects of Cataract Extraction on the Outcomes of Automated Perimetry and Retinal Nerve Fiber Layer Thickness Measurements by Optical Coherence Tomography in Primary Angle Closure Glaucoma

Man¹,

Chan²,

Lau³

et al. 2016

J Clin Exp Ophthalmol

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Objective: To evaluate the effect of cataract extraction on both visual field and retinal nerve fiber layer thickness measurements in primary angle closure glaucoma (PACG) eyes. Methods: Retrospective cohort study on 30 PACG eyes underwent cataract extraction. Changes in RNFL thickness and visual field parameters including mean deviation (MD), visual field index (VFI) and pattern standard deviation (PSD) were analyzed within 6 months before and after cataract extraction. Results: Overall, MD (p=0.003) and VFI (p=0.004) improved significantly after cataract extraction, whereas PSD showed no significant change (p=0.6). In the 10 eyes with MD worse than-20 dB, mean MD improved by 3.4 ± 3.56 dB (from-24.36 ± 3.06 dB to-20.96 ± 5.06 dB, p=0.01) and mean VFI improved by 16.25 ± 15.66% (from 23.38 ± 9.65% to 39.63 ± 20.83%, p=0.02). PSD showed no significant change after cataract extraction (p=0.07). In the 20 eyes with MD better than-20 dB, MD and VFI also improved postoperatively, but the changes did not reach statistical significance: mean MD improved by 1.64 ± 3.65 dB (from-11.57 ± 5.57 dB to-9.92 ± 5.36 dB, p=0.05) whilst mean VFI improved by 4.57 ± 12.29% (from 74.95 ± 17.95% to 79.52 ± 17.26%, p=0.07). RNFL thickness did not show any significant changes after cataract extraction (p=0.13). Conclusions: Both MD and VFI improved after cataract extraction, especially in eyes with pre-operative MD worse than-20 dB. PSD and RNFL thickness showed no significant change after cataract extraction.

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Comparison of Spectralis-OCT, GDxVCC and GDxECC in assessing retinal nerve fiber layer (RNFL) in glaucomatous patients

Cited by 11 publications

References 37 publications

Optical Coherence Tomography, Scanning Laser Polarimetry and Confocal Scanning Laser Ophthalmoscopy in Retinal Nerve Fiber Layer Measurements of Glaucoma Patients

Optical Coherence Tomography, Scanning Laser Polarimetry and Confocal Scanning Laser Ophthalmoscopy in Retinal Nerve Fiber Layer Measurements of Glaucoma Patients

Scanning laser polarimetry in glaucoma

Effects of Cataract Extraction on the Outcomes of Automated Perimetry and Retinal Nerve Fiber Layer Thickness Measurements by Optical Coherence Tomography in Primary Angle Closure Glaucoma

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