Comparison of sotalol with digoxin-quinidine for conversion of acute atrial fibrillation to sinus rhythm (the sotalol-digoxin-quinidine trial)

The safety and efficacy of sotalol in the management of acute atrial fibrillation: a retrospective case control study

“…It is difficult to draw robust conclusions since there were a low number of patients that were recruited in this trial [12].…”

Antiarrhythmic Medications for Cardioversion and Maintenance of Sinus Rhythm in Patients with Cardiac Arrhythmias: A Review of the Literature

“…When administered with propranolol, Antonelli et al found the conversion efficacy rate to be 88%. (Antonelli et al, 1985) The mean time to conversion ranged from 4.0 ± 2.9 hours for quindine and digoxin to 10.8 ± 10.5 hours for quinidine alone [28,30].…”

“…When administering quinidine alone, the conversion efficacy ranged from 40-84% [24,25,27]. Quinidine administered with digoxin had an efficacy range of 47-86% [28,29]. When administered with propranolol, Antonelli et al found the conversion efficacy rate to be 88%.…”

“…Halinen et al compared efficacy of sotalol to quinidine and in the quinidine group administered digoxin if the ventricular rate was >100 bpm. The quinidine group demonstrated superior efficacy to sotalol for conversion of atrial fibrillation to sinus rhythm (86% vs. 52%) [28]. Capucci et al looked at recent onset atrial fibrillation, <8 days, and found that quinidine administered with digoxin was inferior to propafenone (48% vs. 83%) [30].…”

Pharmacological Treatment for Atrial Fibrillation

“…31) In Japan, K channel blockers are less frequently used for prevention of atrial fibrillation because the coverage of the National Health Insurance System price for amiodarone is limited to use in patients with atrial fibrillation accompanied by hypertrophic cardiomyopathy. However, based on clinical results in Europe and America, [12][13][14][15]21,29,30) application of K channel blockers is gradually increasing to include patients suffering from intractable atrial fibrillation. Considering this background, the enrolled patients were still …”