Comparison of sotalol versus amiodarone in maintaining stability of sinus rhythm in patients with atrial fibrillation (Sotalol-Amiodarone Fibrillation Efficacy Trial [Safe-T])

Quality of Life and Exercise Performance in Patients in Sinus Rhythm Versus Persistent Atrial Fibrillation

“…The AF symptom burden score derived from AFSS is a summary score which averages the frequency, duration, and severity of AF episodes; a higher score indicates a greater AF symptomatology. The modified Naughton protocol was used for performing exercise treadmill tests as described previously (10,11). The QOL evaluation and exercise treadmill tests were performed at baseline and at the 8 weeks and 1 year follow-up visits.…”

Medikamentöse Therapie von Herzrhythmusstörungen

“…Amiodaron: Verschiedene Studien [12,13] konnten übereinstimmend belegen, dass Amiodaron das derzeit effektivste Antiarrhythmikum zum Erhalt des Sinusrhythmus ist. So betrug in der CTAF-Studie die Vorhofflimmerrezidivquote während eines Nachbeobachtungszeitraums von 468 ± 150 Tagen unter Amiodaron 35%, während sie bei Patienten, die mit Propafenon oder Sotalol behandelt wurden, bei 63% lag [12].…”

Rate versus rhythm control strategies for AF

“…Fewer strokes occurred in those remaining in AF. • SAFE-T, a double-blind trial of persistent AF, compared sotalol and amiodarone against a placebo measuring time to first AF recurrence once sinus rhythm was established [62]. Despite the fact that the antiarrhythmic drugs were more effective than placebo in maintaining sinus rhythm, there were no significant differences in the incidence of major adverse reactions among the three arms of the trial.…”