Comparison of some effects of acetylsalicylic acid and rofecoxib during orthodontic tooth movement

Sarı, Emel; Ölmez, Hüseyin; Gürton, A.Ümit

doi:10.1016/j.ajodo.2003.04.006

Cited by 46 publications

(26 citation statements)

References 24 publications

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“…These data do not agree with previous studies that showed an increase in the levels of PGE 2 in young individuals (17 years on average) after 24 and 48 hours, and a decrease after 168 hours of application of the orthodontic force. 11,21 In another study, 5 in patients 11 to 27 years old, the levels of pro-inflammatory cytokines were significantly elevated in the early stage of tooth movement but at different time points, IL-6, IL-1β and TNFa at 24 hours and IL-8 at 1 month. However, during the linear stage of tooth movement, all cytokines were reduced to their baseline levels.…”

Section: Discussionmentioning

confidence: 99%

“…Cellular differentiation is also affected, which results in a decreased number of osteoblasts and osteoblastprecursor cells. 11,19,25 The clinical significance of research regarding the mechanism of bone metabolism in orthodontic tooth movement is related to its potential pharmacologic modulation. This includes the effects of adjunctive PGE and IL-1β, as well as prostaglandin-inhibiting drugs, on the rate of tooth movement.…”

Section: Discussionmentioning

confidence: 99%

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Juveniles versus adults: differences in PGE2 levels in the gingival crevicular fluid during orthodontic tooth movement

2010

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Juveniles versus adults: differences in PGE 2 levels in the gingival crevicular fluid during orthodontic tooth movement Abstract: This study aimed to investigate age-related changes in the biosynthetic capacity of prostaglandin E 2 (PGE 2 ) in the gingival crevicular fluid (GCF) during one month of orthodontic treatment. Twentyfive juvenile subjects (mean age 13 ± 2.1 years) and 23 adults (mean age 24 ± 2.1 years) were included. GCF was collected immediately before the force application at the baseline, 2, 21 and 28 days, with periopaper inserted into the gingival crevice of the maxillary lateral incisors. The mediator levels were determined with an EIA kit. The results showed that the PGE 2 concentrations were significantly elevated from the baseline to 21 days (129.35 and 198.84 pg/µL, p = 0.0169) in juvenile subjects and reduced from 21 to 28 days (198.84 to 112.60 pg/µL, p = 0.0032). Adults, however, had no significant changes in the PGE 2 levels. The total amounts of PGE 2 from both groups changed between the baseline to 21 and 21 to 28 days (p = 0.0119 and p = 0.0076, respectively). The PGE 2 initial and final levels showed significant differences between the juveniles and adults, being higher in adults (baseline: juvenile = 129.35 pg/µL vs. adult = 163.20 pg/µL, p = 0.0379; t3: juvenile = 112.60 pg/µL and adult = 175.30 pg/µL, p = 0.0005). In conclusion, the results demonstrate the presence of variation in the PGE 2 levels according to age and the orthodontic activation period, which can explain why the speed of orthodontics treatment may be different in adults vs. juveniles.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Juveniles versus adults: differences in PGE2 levels in the gingival crevicular fluid during orthodontic tooth movement

2010

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“…This inflammatory reaction may trigger biologic processes that result in bone resorption. 1,2 Various cytokines and hormones regulate this process. 3 Proinflammatory cytokines play important roles in bone resorption as in any root resorption process.…”

Section: Introductionmentioning

confidence: 99%

Identification of tumor necrosis factor-α levels around miniscrews during canine distalization

et al. 2011

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Objective: The aim of this study was to measure tumor necrosis factor-α (TNF-α) levels around miniscrews used for anchorage during a 3-month period of canine distalization. Methods: Sixteen patients (8 boys, 8 girls; mean age, 16.6 ± 2.4 years) whose upper first premolars were extracted for orthodontic treatment were included in this study. Miniscrews were used as an anchorage unit in canine distalization. Thirty-two (32) miniscrew implants were placed bilaterally in the alveolar bone between the maxillary second premolars and first molars. The treatment, miniscrew, and control groups comprised upper canines, miniscrew implants, and upper first premolars, respectively. Peri-miniscrew implant crevicular fluid and gingival crevicular fluid were obtained before applying force and at 1, 24, and 48 hours, and at 7 and 21 days, and 3 months after applying force. Results: During the 3-month period, the TNF-α levels increased significantly at 24 hours only in the treatment group (p ＜ 0.01). In the miniscrew and control groups, there were no statistically significant changes. No significant differences were observed between groups. Conclusions: Miniscrews can be conveniently used for anchorage in orthodontics.

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“…38,39 Thus, the trend toward a reduction in the number of osteoclasts observed in the present study indicates that our results need to be reevaluated and confirmed under other experimental sets, including the evaluation of osteoclastogenesis, cell fusion, acidification, and resorptive activity. Sari et al 40 showed that rofecoxib administration did not significantly affect PGE2 levels. However, our study used celecoxib, and the drug could affect other factors, such as interleukin-1 and -6, which are both related to bone resorption and tooth movement.…”

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confidence: 99%

Effects of Short- and Long-Term Celecoxib on Orthodontic Tooth Movement

Gameiro

Noüer

Neto

et al. 2008

The Angle Orthodontist

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Objective: To test the hypothesis that short-and long-term celecoxib administration has no effect on orthodontic tooth movement. Materials and Methods: Male Wistar rats were submitted to short-(3 days) and long-term (14 days) celecoxib administration, while the respective control groups received equivolumetric saline intraperitoneal injections. The upper left first molars of all rats were moved mesially for 14 days by a fixed orthodontic appliance exerting 50 g force upon insertion. After the experimental period, tooth movement was quantified and tissues around the first molar were processed for tartrateresistant acid phosphatase (TRAP) histochemistry. The amount of tooth movement and the number of TRAP-positive cells on the alveolar bone surface were evaluated. Results: The amount of tooth movement was significantly reduced in rats submitted to short-and long-term celecoxib administration, while the number of osteoclasts on the alveolar bone did not differ between the four groups studied. Conclusions: The hypothesis is rejected. Although celecoxib administration did not affect the number of osteoclasts, the osteoclast activity might be reduced, which could explain the inhibition of tooth movement observed in the celecoxib-treated animals. These results indicate that orthodontists should be aware of patients under short-and long-term therapy with celecoxib.

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Comparison of some effects of acetylsalicylic acid and rofecoxib during orthodontic tooth movement

Cited by 46 publications

References 24 publications

Juveniles versus adults: differences in PGE2 levels in the gingival crevicular fluid during orthodontic tooth movement

Juveniles versus adults: differences in PGE2 levels in the gingival crevicular fluid during orthodontic tooth movement

Identification of tumor necrosis factor-α levels around miniscrews during canine distalization

Effects of Short- and Long-Term Celecoxib on Orthodontic Tooth Movement

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