Comparison of soluble urokinase plasminogen activator receptor, soluble triggering receptor expressed on myeloid cells 1, procalcitonin and C-reactive protein in distinguishing concurrent bacterial infection from idiopathic inflammatory myopathy

Ye, Xiao; Luo, Hui; Zhou, Bin; Dai, Xiaodan; Huang, Jing; Duan, Liping; You, Yun; Zhang, Weiru; Zhao, Hongjun; Xie, Yanli; Zhou, Yujun; Ning, Wangbin; Li, Tong; Liu, Sijia; Zhu, Honglin; Xie, Xiaoyun; Jiang, Ying; Wu, Shiyao; He, Weiji; Li, Yisha

doi:10.1007/s00296-016-3609-x

Cited by 8 publications

(8 citation statements)

References 37 publications

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“…4C). In addition, clinical variables such as ASS and ILD, and proteins (plasminogen and thrombospondin) which have previously been linked to myositis were positively correlating with the Jo1 + patients 31–34 . Noteworthy, both the log(FA2_1/FA2_2) and the log Σ[B] data correlated weakly but significantly (R 2 = 0.13, p = 0.003 and R 2 = 0.09, p = 0.01, respectively) with accessible C reactive Protein (CRP) data linked to 70 of the measuring time points, (from 23 of the Jo1 − and of the 17 Jo1 + patients).…”

Section: Discussionmentioning

confidence: 81%

Patients with anti-Jo1 antibodies display a characteristic IgG Fc-glycan profile which is further enhanced in anti-Jo1 autoantibodies

Fernandes‐Cerqueira

Renard

Notarnicola

et al. 2018

Sci Rep

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IgG Fc-glycans affect IgG function and are altered in autoimmune diseases and autoantibodies. Anti-histidyl tRNA synthetase autoantibodies (anti-Jo1) are frequent in patients with idiopathic inflammatory myopathies (IIM) and anti-synthetase syndrome (ASS) with associated interstitial lung disease (ILD). Thus, we hypothesized that the total-IgG Fc-glycans from Jo1+ versus Jo1− patients and anti-Jo1-IgG would show characteristic differences, and that particular Fc-glycan features would be associated with specific clinical manifestations. By proteomics based mass spectrometry we observed a high abundance of agalactosylated IgG1 Fc-glycans in ASS/IIM patients (n = 44) compared to healthy age matched controls (n = 24). Using intra-individual normalization of the main agalactosylated glycan (FA2) of IgG1 vs FA2-IgG2, ASS/IIM and controls were distinguished with an area under the curve (AUC) of 79 ± 6%. For Jo1+ patients (n = 19) the AUCs went up to 88 ± 6%. Bisected and afucosylated Fc-glycans were significantly lower in Jo1+ compared to Jo1− patients. Anti-Jo1-IgG enriched from eleven patients contained even significantly lower abundances of bisected, afucosylated and galactosylated forms compared to matched total-IgG. ASS and ILD diagnosis, as well as lysozyme and thrombospondin correlated with Jo1+ characteristic Fc-glycan features. These results suggest that the anti-Jo1+ patient Fc-glycan profile contains phenotype specific features which may underlie the pathogenic role of Jo1 autoantibodies.

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Section: Discussionmentioning

confidence: 81%

Patients with anti-Jo1 antibodies display a characteristic IgG Fc-glycan profile which is further enhanced in anti-Jo1 autoantibodies

Fernandes‐Cerqueira

Renard

Notarnicola

et al. 2018

Sci Rep

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“…Due to their relative muscle specificity, serum CK levels are most frequently used for the diagnosis and monitoring of IIM, while the other markers (such as LD and transaminases) are present in almost all living cells and are far less specific for muscle damage (45). Moreover, elevated serum CRP is rarely seen in IIM, and is mostly observed in IIM-associated arthritis, ILD or cancer (46)(47)(48). In contrast, based on our diagnostic utility analysis, plasma Hsp90 outperformed CK and CRP in distinguishing IIM from HC, as well as PM and DM from HC.…”

Section: Discussionmentioning

confidence: 99%

Hsp90 Levels in Idiopathic Inflammatory Myopathies and Their Association With Muscle Involvement and Disease Activity: A Cross-Sectional and Longitudinal Study

et al. 2022

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BackgroundHeat shock proteins (Hsp) are chaperones playing essential roles in skeletal muscle physiology, adaptation to exercise or stress, and activation of inflammatory cells. We aimed to assess Hsp90 in patients with idiopathic inflammatory myopathies (IIM) and its association with IIM-related features.MethodsHsp90 plasma levels were analyzed in a cross-sectional cohort (277 IIM patients and 157 healthy controls [HC]) and two longitudinal cohorts to assess the effect of standard-of-care pharmacotherapy (n=39 in early disease and n=23 in established disease). Hsp90 and selected cytokines/chemokines were measured by commercially available ELISA and human Cytokine 27-plex Assay.ResultsHsp90 plasma levels were increased in IIM patients compared to HC (median [IQR]: 20.2 [14.3–40.1] vs 9.8 [7.5–13.8] ng/mL, p<0.0001). Elevated Hsp90 was found in IIM patients with pulmonary, cardiac, esophageal, and skeletal muscle involvement, with higher disease activity or damage, and with elevated muscle enzymes and crucial cytokines/chemokines involved in the pathogenesis of myositis (p<0.05 for all). Plasma Hsp90 decreased upon pharmacological treatment in both patients with early and established disease. Notably, Hsp90 plasma levels were slightly superior to traditional biomarkers, such as C-reactive protein and creatine kinase, in differentiating IIM from HC, and IIM patients with cardiac involvement and interstitial lung disease from those without these manifestations.ConclusionsHsp90 is increased systemically in patients with IIM. Plasma Hsp90 could become an attractive soluble biomarker of disease activity and damage and a potential predictor of treatment response in IIM.

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“…Besides, the retrospective design and the new definition of intraoperative urosepsis may lead to an inaccurate estimation of urosepsis occurrence. Moreover, limited to the study design and missing data, we did not analyze more risk factors such as preoperative midstream urine culture and some biomarkers like C-reactive protein, procalcitonin and intraoperative perfusion pressure, which previous studies have shown a correlation with the risk of sepsis [19, 27, 38–42]. Combining these weak points, our analyses should be interpreted prudently and further multi-center randomized controlled studies including a larger case number are needed.…”

Section: Discussionmentioning

confidence: 99%

Risk factors and outcomes of urosepsis in patients with calculous pyonephrosis receiving surgical intervention: a single-center retrospective study

et al. 2019

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Background Urosepsis is a catastrophic complication, which can easily develop into septic shock and lead to death if not diagnosed early and effectively treated in time. However, there is a lack of evidence on the risk factors and outcomes in calculous pyonephrosis patients. Therefore, this study was conducted to identify risk factors and outcomes of intra- and postoperative urosepsis in this particular population. Methods Clinical data of 287 patients with calculous pyonephrosis were collected. In the univariate and multivariate analysis, all patients were divided into urosepsis group and non-urosepsis group. The diagnosis of urosepsis was mainly on the basis of the criteria of American College of Chest Physicians (ACCP)/Society of Critical Care Medicine (SCCM). Patient characteristics and outcomes data were analyzed, and risk factors were assessed by binary logistic regression analysis. Results Of 287 patients, 41 (14.3%) acquired urosepsis. Univariate analysis showed that white blood cell (WBC > 10*10^9/L) before surgery ( P = 0.027), surgery types ( P = 0.009), hypotension during surgery ( P < 0.001) and urgent surgery ( P < 0.001) were associated with intra- and postoperative urosepsis for calculous pyonephrosis patients. In multivariate analysis, hypotension during surgery and urgent surgery were closely related to intra- and postoperative urosepsis. Outcome analysis suggested that patients developing urosepsis had a longer intensive care unit (ICU) stay and postoperative hospital stay and higher mortality. Conclusions Hypotension during surgery and urgent surgery were risk factors of intra- and postoperative urosepsis for calculous pyonephrosis patients, which may lead to a prolonged ICU stay, postoperative hospital stay and higher mortality.

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Comparison of soluble urokinase plasminogen activator receptor, soluble triggering receptor expressed on myeloid cells 1, procalcitonin and C-reactive protein in distinguishing concurrent bacterial infection from idiopathic inflammatory myopathy

Cited by 8 publications

References 37 publications

Patients with anti-Jo1 antibodies display a characteristic IgG Fc-glycan profile which is further enhanced in anti-Jo1 autoantibodies

Patients with anti-Jo1 antibodies display a characteristic IgG Fc-glycan profile which is further enhanced in anti-Jo1 autoantibodies

Hsp90 Levels in Idiopathic Inflammatory Myopathies and Their Association With Muscle Involvement and Disease Activity: A Cross-Sectional and Longitudinal Study

Risk factors and outcomes of urosepsis in patients with calculous pyonephrosis receiving surgical intervention: a single-center retrospective study

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