Comparison of soluble thrombomodulin, von Willebrand factor, tPA/PAI-1 complex, and high-sensitivity CRP concentrations in serum, EDTA plasma, citrated plasma, and acidified citrated plasma (Stabilyte™) stored at −70 °C for 8–11 years

Nilsson, Torbjörn; Boman, Kurt; Jansson, Jan‐Håkan; Thøgersen, Anna Margrethe; Berggren, Mona; Broberg, Annette; Granlund, Anna

doi:10.1016/j.thromres.2004.12.005

Cited by 44 publications

(34 citation statements)

References 15 publications

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“…Another potential limitation involves the use of frozen serum samples to estimate hs-CRP concentrations, which may have affected the accuracy of these readings. Although we did not monitor longterm changes in hs-CRP levels of stored serum samples, previous studies have confirmed that hs-CRP levels are stable in serum samples stored for up to 7 years at −70 ℃ 45) .…”

Section: Discussionmentioning

confidence: 87%

The Impact of C-Reactive Protein on Risk of Stroke, Stroke Subtypes, and Ischemic Heart Disease in Middle-Aged Japanese: the Japan Public Health Center-Based Study

Iso

Noda

Ikeda

et al. 2012

JAT

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Aim:To examine the impact of C-reactive protein on the risks of stroke and its subtypes, particularly among Asian populations in which median C-reactive protein levels are typically lower than in Western populations. Methods: A prospective, nested case-control study was conducted to examine the associations between high sensitivity-CRP (hs-CRP) and risks of cardiovascular disease within a cohort of 29,876 men and women aged 40-69 years, with no history of stroke, ischemic heart disease or cancer, who submitted blood samples between 1990 and 1993. Systematic cardiovascular surveillance was performed throughout 2007. One control for each stroke and two controls for each ischemic heart disease were matched for sex, age, date of blood drawing, time since last meal and study location. Results: We documented 1,132 incident strokes (638 ischemic and 494 hemorrhagic strokes) and 209 ischemic heart diseases (168 myocardial infarctions and 41 sudden cardiac deaths), and observed a linear association between hs-CRP levels and risks of ischemic stroke and ischemic heart disease, more specifically myocardial infarction. The multivariable odds ratios associated with 1-SD increment of logarithmically transformed hs-CRP were 1.13 (0.99-1.29), p=0.07 for ischemic stroke, 1.16 (0.96-1.41), p=0.13 for lacunar infarction, 1.41 (0.98-2.01), p=0.06 for embolic infarction, and 1.28 (1.03-1.59), p= 0.03 for myocardial infarction. The predictive value of hs-CRP for ischemic stroke was reduced primarily after adjustment for hypertensive status and body mass index. No association was found between hs-CRP levels and the risk of hemorrhagic or total stroke. Conclusions: High serum hs-CRP levels were associated with the risk of myocardial infarction and more weakly with the risk of ischemic stroke among middle-aged Japanese men and women.

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Section: Discussionmentioning

confidence: 87%

The Impact of C-Reactive Protein on Risk of Stroke, Stroke Subtypes, and Ischemic Heart Disease in Middle-Aged Japanese: the Japan Public Health Center-Based Study

Iso

Noda

Ikeda

et al. 2012

JAT

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“…In addition, banked frozen (À80°C) serum samples from 10 dogs participating in a previously published study describing EBP were included. 24,25 Healthy blood donor dogs with no signs of illness, with normal physical examination findings, and with normal hematology and biochemistry findings were eligible for inclusion as healthy controls.…”

Section: Study Populationmentioning

confidence: 99%

Serum C‐Reactive Protein as a Diagnostic Biomarker in Dogs with Bacterial Respiratory Diseases

Viitanen

Laurila

Lilja‐Maula

et al. 2013

Veterinary Internal Medicne

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Background: C-reactive protein (CRP) is a major acute-phase protein in dogs. Serum concentrations are low in healthy animals, but increase rapidly after inflammatory stimuli.Objective: The aim of the study was to investigate CRP concentrations in various respiratory diseases of dogs and to determine if CRP can be used as a biomarker in the diagnosis of bacterial respiratory diseases.Animals: A total of 106 privately owned dogs with respiratory diseases ( Methods: The study was conducted as a prospective cross-sectional observational study. CRP was measured in serum samples. Diagnosis was confirmed by clinical and laboratory findings, diagnostic imaging, and selected diagnostic methods such as cytological and microbiological analysis of respiratory samples, echocardiography, and histopathology.Results: Dogs with BP had significantly higher CRP concentrations (median, 121 mg/L; interquartile range, 68-178 mg/L) than dogs with BTB (23, 15-38, P = .0003), CB (13, 8-14, P < .0001), EBP (5, 5-15, P < .0001), CIPF (17, 10-20, P < .0001), or CPE (19, 13-32, P < .0001) and healthy controls (14,(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20), P < .0001). Dogs with BTB had significantly higher CRP concentrations than dogs with CB (P = .001) or EBP (P < .0001) and healthy controls (P = .029).Conclusion and Clinical Importance: These results indicate that CRP has potential for use as an additional biomarker, especially in the diagnostics of BP.

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“…22,28 Macy et al 22 reported several types of intra-individual variability using samples collected at a single time point. They compared sample types; serum, SCAT-1 plasma, SCAT-2 plasma, EDTA plasma, and citrate plasma samples in six individuals, CRP values were lower in sodium citrate tubes than in other types of Ishikawa S, et al studies or cohort studies, when we examine new risk factors.…”

mentioning

confidence: 99%

“…They also found that there were no significant differences in CRP levels with up to a 6 hour delay in specimen processing. Nisson et al 28 reported in 34 patients admitted to a coronary care unit using 10 year frozen samples that hsCRP showed a predictable slope in the regression between serum and citrate plasma ([hsCRP]citrate=0.902…”

mentioning

confidence: 99%

Comparison of C-reactive Protein Levels between Serum and Plasma Samples on Long-term Frozen Storage after a 13.8 Year Interval: The JMS Cohort Study

Ishikawa

Kayaba

Gotoh

et al. 2007

Journal of Epidemiology

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Comparison of soluble thrombomodulin, von Willebrand factor, tPA/PAI-1 complex, and high-sensitivity CRP concentrations in serum, EDTA plasma, citrated plasma, and acidified citrated plasma (Stabilyte™) stored at −70 °C for 8–11 years

Cited by 44 publications

References 15 publications

The Impact of C-Reactive Protein on Risk of Stroke, Stroke Subtypes, and Ischemic Heart Disease in Middle-Aged Japanese: the Japan Public Health Center-Based Study

The Impact of C-Reactive Protein on Risk of Stroke, Stroke Subtypes, and Ischemic Heart Disease in Middle-Aged Japanese: the Japan Public Health Center-Based Study

Serum C‐Reactive Protein as a Diagnostic Biomarker in Dogs with Bacterial Respiratory Diseases

Comparison of C-reactive Protein Levels between Serum and Plasma Samples on Long-term Frozen Storage after a 13.8 Year Interval: The JMS Cohort Study

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