Comparison of sodium, potassium, calcium, magnesium, zinc, copper and iron concentrations of elements in 24-h urine and spot urine in hypertensive patients with healthy renal function

Chang, Xiaoyu; Liu, Wanlu; Li, Xiaoxia; Wang, Faxuan; Huang, Liping; Liao, Shuhan; Liu, Xiuying; Zhang, Yuhong; Zhao, Yi

doi:10.1016/j.jtemb.2017.06.006

Cited by 17 publications

(10 citation statements)

References 27 publications

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“…Thus, urine magnesium concentration was only used as a descriptive marker in this work and its association with cardiovascular risk factors was not analyzed. There are several works showing a good correlation between magnesium concentrations in the early morning urine sample and magnesium in the 24-hour urine collection method [66,67]. Some authors, however, have indicated that the early morning urine sample and the 24-hour urine collection cannot be used interchangeably in the evaluation of urinary magnesium excretion, as a good correlation does not translate into an agreement between the two measurements [68].…”

Section: Discussionmentioning

confidence: 99%

Influence of Demographic and Lifestyle Variables on Plasma Magnesium Concentrations and Their Associations with Cardiovascular Risk Factors in a Mediterranean Population

et al. 2020

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Several studies have shown that a low magnesium (Mg) intake in the diet is associated with greater cardiovascular risk and greater risk of diabetes. However, the results are not consistent in all populations. To minimize the biases derived from diet measurement, more objective biomarkers of magnesium status have been proposed. Although there is still no ideal biomarker for Mg, several studies have shown that plasma Mg concentrations could be a relatively acceptable biomarker for cardiovascular risk assessment. However, further studies are required to better characterize this marker in different populations. Our aim was to analyze the association between plasma Mg concentrations (measured through inductively coupled plasma mass spectrometry (ICP-MS)) methods, and cardiovascular risk factors in individuals from a general Mediterranean population (aged 18–80 years). The influence of demographic and lifestyle variables, including adherence to the Mediterranean diet, on plasma Mg concentrations was analyzed. The mean Mg level of the population studied was 0.77 ± 0.08 mmol/L, the prevalence of hypomagnesemia (<0.70 mmol/L) being 18.6%. We did not find any statistically significant differences between plasma Mg concentrations and sex, age, tobacco smoking and total adherence to the Mediterranean diet (p > 0.05). We found a statistically significant association between plasma Mg concentrations and the prevalence of type-2 diabetes (0.77 ± 0.08 mmol/L in non-diabetics versus 0.73 ± 0.13 mmol/L in diabetics; p = 0.009). Despite the low prevalence of type-2 diabetes in this population (11.24% in subjects with hypomagnesemia versus 3.91%, in normomagnesemia; p = 0.005), hypomagnesemia was associated with greater odds of being diabetic in comparison with normomagnesemia (OR = 3.36; p = 0.016, even after adjustment for sex, age, obesity, and medications). On the other hand, no statistically significant association of plasma Mg concentrations with obesity, hypertension, fasting triglycerides, HDL-cholesterol or uric acid was found. However, in contrast to what was initially expected, a statistically significant association was found between plasma Mg concentrations (basically in the highest quartile) and greater total cholesterol (p < 0.05) and LDL-cholesterol concentrations (p < 0.05). In conclusion, our results contribute to increasing the evidence gathered by numerous studies on the inverse association between hypomagnesemia and type-2 diabetes, as well as to the observation, previously reported in some studies, of a direct association with hypercholesterolemia. This paradoxical link should be deeply investigated in further studies.

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Section: Discussionmentioning

confidence: 99%

Influence of Demographic and Lifestyle Variables on Plasma Magnesium Concentrations and Their Associations with Cardiovascular Risk Factors in a Mediterranean Population

et al. 2020

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“…Among chemicals, potassium ions have critical importance for all levels of vital activities [2]. In fact, potassium monitoring in food and serum [3], urine [4], and potentially in brain [5] has been a routine analysis in the clinical and medical fields to reveal physical conditions of the patients having renal diseases, hypopotassemia, alkalosis, cirrhosis of liver, or using diuretic drugs [6]. Thus, miniaturized K + sensor is highly demanded for wearable health monitoring system.…”

Section: Introductionmentioning

confidence: 99%

Potassium Ion Selective Electrode Using Polyaniline and Matrix-Supported Ion-Selective PVC Membrane

2018

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Solid-state potassium ion selective electrode (K + ISE) has been the most studied chemical sensors due to its practical importance in biomedical applications. One of the major obstacles that prevented widespread use of solid-state K + ISE has been output potential drift problem. In this paper, we developed an electrochemical sensing unit in which working, counter, and reference electrodes are integrated in a single plane as all-solid-state form. In order to mitigate the output potential drift, a polyaniline intermediate layer and salt-saturated polyvinylebutyral top coating are introduced in the working and reference electrodes, respectively. Using cyclic voltammetry (CV), uniform layers of polyaniline are deposited on carbon electrode, as confirmed by scanning electron microscope observation. Potentiometry and electrochemical impedance spectroscopy measurement on our K + ISE show high sensitivity (60.5 mV/decade), low concentration for the limit of detection (10 −5.8 M), and large range of linear detection (10 −5 − 1 M), and superior selectivity of K + ISE against NH + 4 , Na + , Mg 2+ , Ca 2+ , and Fe 3+. With its high potential to be miniaturized, we foresee that our solid-state K + ISE will motivate the future applications in microdevices for clinical analysis, agricultural, and environmental applications.

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“…In addition, care should be taken to avoid external contaminations, which are very common for urine collections (27). At last, this determination is not applicable in case of renal impairment (28). Interpreting 24-h urinary copper excretion may be difficult.…”

Section: H-urinary Copper Excretionmentioning

confidence: 99%

New tools for Wilson’s disease diagnosis: exchangeable copper fraction

Djebrani‐Oussedik

Poujois

2019

Ann. Transl. Med

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Wilson's disease (WD) biochemical markers continue to evolve. Classical tests [serum copper, serum ceruloplasmin (Cp), urinary copper] have their own limits, and they are often insufficient to diagnose or exclude WD. So, calculated estimation of copper that is not bound to Cp has been proposed, but it is flawed. Therefore, we focused our research on a direct measurement of serum copper labile fraction. Exchangeable copper (CuEXC) offers a correct view of the free copper overload. It provides information on the spread and severity of WD. Relative exchangeable copper (REC) (percentage of exchangeable to total serum copper) that appreciates the toxic fraction of copper in blood is an excellent biomarker for WD diagnosis. These two tests are reliable and non-invasive. They give rapid answers for an appropriate diagnosis and make possible to start the treatment quickly without waiting for the result of the genetic tests.

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Comparison of sodium, potassium, calcium, magnesium, zinc, copper and iron concentrations of elements in 24-h urine and spot urine in hypertensive patients with healthy renal function

Cited by 17 publications

References 27 publications

Influence of Demographic and Lifestyle Variables on Plasma Magnesium Concentrations and Their Associations with Cardiovascular Risk Factors in a Mediterranean Population

Influence of Demographic and Lifestyle Variables on Plasma Magnesium Concentrations and Their Associations with Cardiovascular Risk Factors in a Mediterranean Population

Potassium Ion Selective Electrode Using Polyaniline and Matrix-Supported Ion-Selective PVC Membrane

New tools for Wilson’s disease diagnosis: exchangeable copper fraction

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