Comparison of small intestinal submucosa and polypropylene mesh for abdominal wall defect repair

Abstract

Abdominal wall defects are a common medical problem, and inadequate repair methods can lead to serious complications. Abdominal wall reconstruction using autologous tissue, or non-biological, biological, or composite patches is often performed to repair defective areas. In particular, composite patches containing both polymeric and biological materials have gained increasing attention due to their good mechanical properties and biocompatibility. However, it is still unclear whether the quality of repairs using composite patches is superior to that of a biological patch. Based on the limitations of previous studies, we compared small intestinal submucosa (SIS) patches with SIS + polypropylene mesh (PPM) patches for repairing abdominal wall defects in adult beagle dogs. Forty-five female dogs were subjected to surgical resection to produce abdominal wall defects. SIS or SIS + PPM was used as patch for the defects. Morphology, biomechanics, and histological evaluations were performed to evaluate the efficacy and safety of such therapies. Our findings demonstrated that SIS had advantages over SIS + PPM considering biological activity and histocompatibility without increasing the risk of repair failure.

Application of antibody-conjugated small intestine submucosa to capture urine-derived stem cells for bladder repair in a rabbit model

“…As a xenogeneic, acellular, biocompatible, biodegradable, and collagen-based scaffold, porcine SIS can enable bladder regeneration without ex vivo cell seeding before the implantation [ [40] , [41] , [42] , [43] ]. The particular biochemical components and excellent mechanical properties have conferred it with appropriate structure and microenvironment not only as a scaffold but also with specific physiological functions suitable for cell adhesion, proliferation, differentiation, and the ultimate tissue regeneration [ 35 , [44] , [45] , [46] , [47] , [48] , [49] , [50] , [51] , [52] , [53] ].…”

The Pathogenicity and Transcriptome Analysis of Methicillin-Resistant Staphylococcus aureus in Response to Water Extract of Galla chinensis

“…Then, we split the rat tibia shaft longitudinally for the histological evaluations. Briefly, the tibias were fixed in 10% neutral buffered formalin, decalcified in 10% EDTA, and embedded in paraffin as previously described [26]. The 5 μ m slices were Gram-stained to assess bacterial colonization.…”

Local wound management: A review of modern techniques and products

“…body wall defects following major oncological surgery, or perineal hernia repair). [113][114][115][116] Combination matrix based wound products have the advantage of synergistic effects of the various components in the matrix or dressing. An example is the combination of collagen and oxidised regenerated cellulose in a dressing sheet (e.g.…”

“…SIS xenografts commonly are used in veterinary patients to provide structural integrity to large wound defects (e.g. body wall defects following major oncological surgery, or perineal hernia repair) 113–116 …”