Comparison of skin calming effects of cosmetic products containing 4‐t‐butylcyclohexanol or acetyl dipeptide‐1 cetyl ester on capsaicin‐induced facial stinging in volunteers with sensitive skin

Abstract

Objective To assess and compare the skin calming effect of cosmetic products containing 4-t-butylcyclohexanol (Eucerin â UltraSensitive Soothing Care Dry Skin) or acetyl dipeptide-1 cetyl ester (La Roche-Posay Toleriane â UltraIntense Soothing Care) on subjective symptoms of skin sensitivity, a controlled, single-blind, randomized split-face capsaicin-induced stinging test was conducted.Methods Thirty-one female test subjects, ranging from 19 to 65 years of age, with self-perceived sensitive to very sensitive skin were enrolled. After a 3-day preconditioning period with no application of facial products and positive reaction to stimulation with a 40 ppm capsaicin cream, the test products were randomly applied to either the right or left nasolabial fold. Burning severity was assessed immediately after capsaicin application, and 1, 2, 5, 10 and 15 min after application of the test products.Results All 31 subjects reported a stinging/burning sensation on both nasolabial folds after application of capsaicin.Treatment with the 4-t-butylcyclohexanol containing product resulted in significant lower values for burning/stinging after one, and two minutes post-application in comparison to the values for the acetyl dipeptide-1 cetyl ester containing product. No significant difference was determined between the two test products for the point in time with most intense burning sensation, the severity of burning and the duration of burning after capsaicin application and subsequent application of the test products.Conclusion Both products alleviated capsaicin-induced burning during the first 15 min after application. A faster and more pronounced soothing effect in vivo was demonstrated for the 4-t-butylcyclohexanol containing cosmetic product in comparison to the acetyl dipeptide-1 cetyl ester containing cosmetic formulation.

A novel multifunctional skin care formulation with a unique blend of antipollution, brightening and antiaging active complexes

“…Studies have shown the importance of specific barrier markers such as FLG, AQP3, Caspase 14, keratin10 in maintaining skin pH, water holding capacity, natural moisturizing factors (NMFs) production, and keratinocyte differentiation . Earlier study identified acetyl dipeptide‐1 cetyl ester as skin calming active on capsaicin‐induced facial stinging in volunteers with sensitive skin, but nothing was reported about its impact on skin barrier properties. Here, using in vitro keratinocyte monoculture model, we showed that acetyl dipeptide 1 cetyl ester (active D) significantly upregulated all tested epidermal barrier genes (Figure A).…”

Clinical evidences of benefits from an advanced skin care routine in comparison with a simple routine

“…Nonetheless, the percentage of positive respondents was slightly in favor of the AR group. Yet, it is worth mentioning that the AR was not formulated specifically for this type of skin concern but some data indicate that a routine purely intended to address this type of issue can perform with the right actives …”

“…While countless vehicle‐controlled studies have demonstrated about the benefit of actives over a vehicle alone and/or vs gold standard ingredients, clinical evidence about the benefits of a skin care routine remains scarce, despite the claimed benefits of using products as part of a regimen. Reported efficacy of regimens is available in the dermatological field, to address skin conditions such as acne, atopic dermatitis, or rosacea . The efficacy of a skin care regimen comprising of a serum with a retinol ester, a lotion with SPF 30 and a night cream, was evaluated vs another regimen consisting of a SPF 30 sunscreen combined with a prescription tretinoin formulation, a very potent active .…”

Characterization of Reactive and Sensitive Skin Microbiota: Effect of Halymenia durvillei (HD) Extract Treatment

“…The concept of the human skin exposome was introduced more than a decade ago, inducing cutaneous aging, sensitive, and reactive skin [18]. Hyperreactivity of the skin's neural response is postulated to play a role in sensitive skin [19]. The treatment of reactive skin is challenging and generally based on the continuous and topical application of antisensitive, moisturizing, and extreme tolerance products that improve skin features.…”