Comparison of Six Oxygen Delivery Systems for COPD Patients at Rest and during Exercise

Braun, Sheldon R.; Spratt, Ginger; Scott, Graham; Ellersieck, Mark R.

doi:10.1378/chest.102.3.694

Cited by 31 publications

(28 citation statements)

References 11 publications

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“…Braun et al 21 again compared COPD patient oxygenation using 5 different PF devices with a constant pulse volume or constant minute volume. At rest, PF was found to be equivalent to CF.…”

Section: Discussionmentioning

confidence: 99%

Effect of the Anatomic Reservoir on Low-Flow Oxygen Delivery Via Nasal Cannula: Constant Flow Versus Pulse Flow With Portable Oxygen Concentrator

Zhou

Chatburn

2014

Respir Care

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BACKGROUND: The F IO 2 for a nasal cannula with constant flow (CF) depends on the anatomic reservoir (AR), which is affected by changes in frequency and end-expiratory flow. Conversely, pulse flow (PF) devices do not require the AR. The purpose of this study was to compare the F IO 2 delivered by a nasal cannula supplied by CF via oxygen tank with that delivered by PF delivered via portable oxygen concentrator. Hypotheses were (1) a lung model of COPD with non-zero end-expiratory flow decreases F IO 2 for CF more than for PF, and (2) CF and PF perform differently in terms of F IO 2 delivery, despite having equivalent settings. METHODS: Normal and COPD lung models were simulated (IngMar Medical ASL 5000) using published human data: normal: breathing frequency ‫؍‬ 15 breaths/min, R in ‫؍‬ 4 cm

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“…Braun et al 21 again compared COPD patient oxygenation using 5 different PF devices with a constant pulse volume or constant minute volume. At rest, PF was found to be equivalent to CF.…”

Section: Discussionmentioning

confidence: 99%

Effect of the Anatomic Reservoir on Low-Flow Oxygen Delivery Via Nasal Cannula: Constant Flow Versus Pulse Flow With Portable Oxygen Concentrator

Zhou

Chatburn

2014

Respir Care

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“…Ambulatory oxygen was delivered through small pressurised cylinders (PulseDose EX-2000D; DeVilbiss, Sunrise Medical, CA, USA; fig. 1) [9]. As some of the benefits obtained from ambulatory oxygen therapy can be ascribed to a placebo effect [10], a third study period was included, where patients were provided with portable compressed air.…”

Section: Interventionsmentioning

confidence: 99%

Randomised trial of ambulatory oxygen in oxygen-dependent COPD

Lacasse¹

2005

European Respiratory Journal

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Long-term oxygen therapy may limit a patient's ability to remain active and may be detrimental to the rehabilitation process. This study aimed to determine the effect of ambulatory oxygen on quality of life and exercise capacity in patients with chronic obstructive pulmonary disease fulfilling the usual criteria of long-term oxygen therapy.In a 1-yr, randomised, three-period, crossover trial, 24 patients (mean age 68 yrs; mean arterial partial pressure of oxygen at rest 7.1 kPa (53 mmHg)) were allocated to one of the six possible sequences generated by three interventions: 1) standard therapy (home oxygen therapy with an oxygen concentrator only); 2) standard therapy plus as-needed ambulatory oxygen; and 3) standard therapy plus ambulatory compressed air. The comparison of ambulatory oxygen versus ambulatory compressed air was double blind. The main outcomes were quality of life (Chronic Respiratory Questionnaire), exercise tolerance (6-min walk test) and daily duration of exposure to oxygen therapy.The trial was stopped prematurely after an interim analysis. On average, the patients used few ambulatory cylinders (7.5 oxygen cylinders versus 7.4 compressed air cylinders over a 3-month study period). Ambulatory oxygen had no effect on any of the outcomes.In conclusion, the current results do not support the widespread provision of ambulatory oxygen to patients with oxygen-dependent chronic obstructive pulmonary disease.

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“…When the patient is at rest, the 2 types of systems have proven to be equivalent. [9][10][11] However, when oxygen requirements increase, specifically during exercise [10][11][12][13][14][15][16] and in patients with ILD, 17 oxygenconserving devices do not seem to provide equivalent benefits.…”

Section: Introductionmentioning

confidence: 99%

Are Oxygen-Conserving Devices Effective for Correcting Exercise Hypoxemia?

Martí

Pajares²,

Morante³

et al. 2013

Respir Care

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BACKGROUND: Correction of exercise hypoxemia in advanced lung diseases is crucial and often challenging. However, oxygen-conserving devices have been introduced in the market with limited evidence of effectiveness. In the present study the efficacy of 2 oxygen-conserving devices, a pulse demand oxygen delivery (DOD) system and pendant reservoir cannula (PRC), were evaluated in subjects with COPD and interstitial lung disease (ILD). METHODS: A cross-sectional, crossover study included 28 COPD and 31 ILD subjects with oxygen desaturation on the 6-min walk test (average S pO 2 < 88%). Each subject underwent 3 walk tests with DOD, PRC, and continuous oxygen flow by standard nasal cannula (CFNC), in random order, taking average S pO 2 > 90% as the resaturation criterion. RESULTS: Exercise desaturation was corrected in 79%, 79%, and 86% of COPD subjects with CFNC, DOD, and PRC, respectively, and in 77%, 61%, and 81% of ILD subjects with CFNC, DOD, and PRC, respectively. When compared to CFNC, the oxygen-conserving devices showed similar efficacy, except a lower performance for the DOD in the ILD subjects (P ‫؍‬ .01). CONCLUSIONS: Although these oxygen-conserving devices corrected exercise hypoxemia in most COPD and ILD subjects, correction was not achieved in about 20% of the severe COPD subjects, regardless of the device, and in nearly 40% of the ILD subjects with the DOD device. These findings underscore that individualized adjustment of oxygen flow is needed for optimal correction of exercise hypoxemia, especially with a DOD in an ILD patient. (Clinical Trials.gov NCT01086891).

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Comparison of Six Oxygen Delivery Systems for COPD Patients at Rest and during Exercise

Cited by 31 publications

References 11 publications

Effect of the Anatomic Reservoir on Low-Flow Oxygen Delivery Via Nasal Cannula: Constant Flow Versus Pulse Flow With Portable Oxygen Concentrator

Effect of the Anatomic Reservoir on Low-Flow Oxygen Delivery Via Nasal Cannula: Constant Flow Versus Pulse Flow With Portable Oxygen Concentrator

Randomised trial of ambulatory oxygen in oxygen-dependent COPD

Are Oxygen-Conserving Devices Effective for Correcting Exercise Hypoxemia?

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