Comparison of simultaneous 18F-2-[18F] FDG PET/MR and PET/CT in the follow-up of patients with differentiated thyroid cancer

Klain, Michele; Nappi, Carmela; Nicolai, Emanuele; Romeo, Valeria; Piscopo, Leandra; Giordano, A; Gaudieri, Valeria; Zampella, Emilia; Pace, Leonardo; Cavaliere, Carlo; Salvatore, Marco; Schlumberger, Martin; Cuocolo, Alberto

doi:10.1007/s00259-020-04938-0

Cited by 30 publications

(18 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…3 Other studies have reported different cut-offs of serum Tg levels for predicting PET/CT results. 5,21 Klain et al 16 reported that PET/MR was positive in 10/22 patients (45%) with serum Tg ≥ 2 ng/mL and in only 1/18 patients (5%) with serum Tg < 2 ng/mL. To our knowledge, there has been no study concerning serum Tg levels for predicting PET/MR results.…”

Section: Discussionmentioning

confidence: 97%

“…Similarly, a recent study showed that PET/ MR brought only slight improvements over PET/CT numerically. 16 In this study, we did not compare the diagnostic ability of PET/MR and PET/CT because none of the patients had PET/CT scans at the same time. In the present study, PET/ MR was able to identify metastatic cervical lymph nodes in four patients classified as benign lesions by MRI, and pulmonary metastases in two patients missed by MRI.…”

Section: Discussionmentioning

confidence: 99%

“…13,14 There are currently few studies with a limited number of cases on the application of 18 F-FDG PET/MR in DTC patients. 15,16 These studies revealed that PET/MR performed equivalently to PET/CT. However, PET/MR appeared to be less sensitive than PET/CT in assessing lung nodules.…”

Section: Introductionmentioning

confidence: 98%

See 2 more Smart Citations

Value of 18F-FDG Hybrid PET/MR in Differentiated Thyroid Cancer Patients with Negative 131I Whole-Body Scan and Elevated Thyroglobulin Levels

Chen

Wang

et al. 2021

CMAR

View full text Add to dashboard Cite

Purpose: To evaluate the diagnostic performance of 18 F-FDG PET/MR in detecting recurrent or metastatic disease in patients with differentiated thyroid cancer (DTC) who have increased thyroglobulin (Tg) levels but a negative 131 I whole-body scan (WBS). The relationship between 18 F-FDG PET/MR and serum Tg levels was explored. We also evaluated the therapeutic impact of PET/MR on patient clinical management. Patients and Methods: Twenty-nine DTC patients with a negative 131 I-WBS of the last post-therapeutic and increased Tg levels under thyroid-stimulating hormone suppression treatment who underwent 18 F-FDG PET/MR examination were retrospectively analyzed. Results: Of those 29 patients, 18 F-FDG PET/MR findings were true positive, true negative, false positive, and false negative in 18, 7, 2, and 2 patients, respectively. The overall sensitivity, specificity, and accuracy were 90.0%, 77.8%, and 86.2%, respectively. We noticed significant differences in serum Tg levels between the PET/MR-positive and PET/ MR-negative patient groups (P=0.049). Receiver operating characteristic curve analysis showed that a Tg level of 2.4 ng/mL was the optimal cut-off value for predicting PET/MR results. The sensitivity, specificity, and accuracy of PET/MR were higher in patients with Tg levels greater than 2.4 ng/mL than in patients with lower levels. By detecting recurrent or metastatic disease, 18 F-FDG PET/MR altered the clinical management in 7 patients (24.1%) of the overall population. Conclusion: 18 F-FDG PET/MR has high diagnostic accuracy for detecting recurrent or metastatic diseases in DTC patients and is useful for clinical management.

show abstract

Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Value of 18F-FDG Hybrid PET/MR in Differentiated Thyroid Cancer Patients with Negative 131I Whole-Body Scan and Elevated Thyroglobulin Levels

Chen

Wang

et al. 2021

CMAR

View full text Add to dashboard Cite

show abstract

“…Ultimately, the literature search led to 15 studies suitable for the inclusion in the systematic review and meta-analysis [19][20][21][22][23][24][25][26][27][28][29][30][31] .…”

Section: Literature Search and Eligibility Assessmentmentioning

confidence: 99%

“…Freudenberg et al [19] 2007 36 Papillary (21), Follicular (15) CT Histology, clinical follow-up Klain et al [20] 2020 40 Differentiated (papillary = 30) MRI, 18 F-FDG PET/MRI Clinical follow-up Kundu et al [21] 2015 62 Papillary (56), Follicular ( 6) 68 Ga-DOTANOC PET/CT Histology, clinical follow-up Leboulleux et al [22] 2012 34 Papillary (32), Follicular (2), Poorly differentiated (2)…”

Section: Years No Patients Histotype Other Imaging Modalities Used For Comparison Standard Of Referencementioning

confidence: 99%

Role of 18F-FDG PET/CT in detection of hematogenous metastases of advanced differentiated thyroid carcinoma: a systematic review and meta-analysis

Quartuccio¹,

Rubello²

2021

JCMT

View full text Add to dashboard Cite

show abstract

Recent Advances in Radio‐Frequency Coil Technologies: Flexible, Wireless, and Integrated Coil Arrays

Darnell

Truong

Song

2021

Magnetic Resonance Imaging

View full text Add to dashboard Cite

Radio-frequency (RF) coils are to magnetic resonance imaging (MRI) scanners what eyes are to the human body. Because of their critical importance, there have been constant innovations driving the rapid development of RF coil technologies. Over the past four decades, the breadth and depth of the RF coil technology evolution have far exceeded the space allowed for this review article. However, these past developments have laid the very foundation on which some of the recent technical breakthroughs are built upon. Here, we narrow our focus on some of the most recent RF coil advances, specifically, on flexible, wireless, and integrated coil arrays. To provide a detailed review, we discuss the theoretical underpinnings, experimental implementations, promising results, as well as future outlooks covering these exciting topics. These recent innovations have greatly improved patient comfort and ease of scan, while also increasing the signal-to-noise ratio, image resolution, temporal throughput, and diagnostic and treatment accuracy. Together with advances in other MRI subfields, they will undoubtedly continue to drive the field forward and lead us to an ever more exciting future. Level of Evidence: 5 Technical Efficacy: Stage 1

show abstract

Comparison of simultaneous 18F-2-[18F] FDG PET/MR and PET/CT in the follow-up of patients with differentiated thyroid cancer

Cited by 30 publications

References 21 publications

Value of 18F-FDG Hybrid PET/MR in Differentiated Thyroid Cancer Patients with Negative 131I Whole-Body Scan and Elevated Thyroglobulin Levels

Value of 18F-FDG Hybrid PET/MR in Differentiated Thyroid Cancer Patients with Negative 131I Whole-Body Scan and Elevated Thyroglobulin Levels

Role of 18F-FDG PET/CT in detection of hematogenous metastases of advanced differentiated thyroid carcinoma: a systematic review and meta-analysis

Recent Advances in Radio‐Frequency Coil Technologies: Flexible, Wireless, and Integrated Coil Arrays

Contact Info

Product

Resources

About