Comparison of short-term results of intraarticular platelet-rich plasma (PRP) and hyaluronic acid treatments in early-stage gonarthrosis patients

Abstract

The present study aimed to compare short-term clinical outcomes between intraarticular platelet-rich plasma (PRP) and hyaluronic acid (HA) treatments in early-stage gonarthrosis patients. Data of gonarthrosis patients, who were stage 1 or stage 2 according to Kellgren-Lawrence classification and underwent intraarticular PRP or HA treatment, were obtained retrospectively. The patients received treatment for three times at one-week intervals (intraarticular PRP or HA). They were evaluated using the Knee Society's Knee Scoring System (KSS) and the visual analog scale (VAS) scoring system before treatment and at the second and sixth months of treatment. The study included 132 patients (mean age, 55.06±8.41 years). Sixty-three patients (86 knees) were in the HA group and 69 patients (89 knees) were in the PRP group. Changes in KSS and VAS scores over time and the differences between the treatment groups in terms of changes in KSS and VAS scores over time were significant. In conclusion, PRP appears to be an appropriate option for intraarticular treatment in patients with early-stage knee osteoarthritis.

Platelet-Rich Plasma Augmentation of Arthroscopic Hip Surgery for Femoroacetabular Impingement: A Prospective Study With 24-Month Follow-up

“…Analysis of these 3 variables showed that GPS III has some proinflammatory cells that may reduce the anti-inflammatory effect of PRP. 33,34 We conducted a comprehensive review of publications to date. However, we could not find any items directly related to hip arthroscopy.…”

Is there a treatment protocol in which platelet-rich plasma is effective?

“…34 It is also known that transforming growth factor beta-1 induces chondrogenic activity 2 and fibroblastic growth factor; bone morphogenetic protein-2, -4, -6 induces osteoblastic stimulation and osteogenesis, 2,35 bone morphogenetic protein-12 induces tenogenic activity. 36 Nonetheless, without knowing the concentration of growth factors in PRP content and compound, they are applied.…”

Tratamiento farmacológico invasivo articular en la artrosis

“…Las variables estudiadas de alivio del dolor y mejoría en el funcionalismo mejoraron en ambos grupos comparado con placebo, encontrando resultados prometedores sin diferencias significativas entre ambos modelos de tratamiento. Concluyó que el PRP podría ser una modalidad a tener en cuenta en etapas inicilaes de gonartrosis, sobre todo en adultos jóvenes (6).…”