Comparison of Short- and Long-Term Cardiac Mortality in Early Versus Late Stent Thrombosis (from Pooled PROTECT Trials)

Secemsky, Eric A.; Matteau, Alexis; Yeh, Robert W.; Steg, Philippe Gabriel; Camenzind, Edoardo; Wijns, William; McFadden, Eugène; Mauri, Laura

doi:10.1016/j.amjcard.2015.03.010

Cited by 41 publications

(23 citation statements)

References 23 publications

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“…We found that early ST was associated with significantly higher inhospital and 30-day mortality, in keeping with the findings of previously published studies [18,19] found to be a predictor of ST, which was not the case in our study. The significant increase in the rate of minor bleeding in the early ST could be explained by the higher and longer use of anticoagulation post repeat revascularization.…”

Section: Discussionsupporting

confidence: 93%

Incidence, predictors, and clinical outcomes of early stent thrombosis in acute myocardial infarction patients treated with primary percutaneous coronary angioplasty (insights from the University of Ottawa Heart Institute STEMI registry)

Singh

Rashid

et al. 2017

Cathet Cardio Intervent

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Section: Discussionsupporting

confidence: 93%

Incidence, predictors, and clinical outcomes of early stent thrombosis in acute myocardial infarction patients treated with primary percutaneous coronary angioplasty (insights from the University of Ottawa Heart Institute STEMI registry)

Singh

Rashid

et al. 2017

Cathet Cardio Intervent

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“…DAPT significantly reduces the risk of stent thrombosis, 50,51,94,95,99 and discontinuation of DAPT in the weeks after stent implantation is one of the strongest risk factors for stent thrombosis, with the magnitude of risk and impact on mortality rate inversely proportional to the timing of occurrence after the procedure . 145,149,150 Older observational studies found that the risk of stent-related thrombotic complications is highest …”

Section: Perioperative Management-timing Of Elective Noncardiac Surgementioning

confidence: 99%

2016 ACC/AHA Guideline Focused Update on Duration of Dual Antiplatelet Therapy in Patients With Coronary Artery Disease: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines: An Update of the 2011 ACCF/AHA/SCAI Guideline for Percutaneous Coronary Intervention, 2011 ACCF/AHA Guideline for Coronary Artery Bypass Graft Surgery, 2012 ACC/AHA/ACP/AATS/PCNA/SCAI/STS Guideline for the Diagnosis and Management of Patients With Stable Ischemic Heart Di

et al. 2016

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“…7 Recent data suggest lower mortality than previously reported, with early ST having higher in-hospital mortality than late or very late ST (7.9, 3.8, and 3.6%, respectively, p < 0.001). 11,12 Our in-hospital mortality in patients who presented with STEMI due to ST was 2%.…”

Section: Discussionmentioning

confidence: 99%

ST-segment Elevation Myocardial Infarction Resulting from Stent Thrombosis in Contemporary Real-World Practice

et al. 2016

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Stent thrombosis (ST) is a rare but devastating complication after percutaneous coronary intervention. Newer generation drug-eluting stents (DES) and newer antiplatelet therapies have been shown to decrease the incidence of ST, but we continue to observe ST-segment elevation myocardial infarction (STEMI) due to ST in contemporary practice. A retrospective analysis of 527 patients who presented with STEMI was performed; 57 patients (11%) with angiographically confirmed ST were compared with the patients with STEMI due to de novo lesion. The type of previous stent, the timing of ST, and the use of antiplatelet therapy were reviewed in patients with ST. Patients with ST had higher prevalence of comorbid conditions, such as hypertension, diabetes mellitus, and coronary artery disease, and had lower left ventricular ejection fraction (37???5 vs. 44???16%, p?=?0.0011). There was no difference in in-hospital mortality (2 vs. 4%, p?=?0.7082). ST was seen most commonly as ?very late? (56%), and with previous second-generation DES (40%). Eighty-two percent of patients among early ST, compared with 22% of patients with very late ST were on dual antiplatelet therapy (DAPT). In 12% of patients, ST happened after DAPT was stopped by physician for procedures. ST is seen in a variety of clinical settings with the most common presentation being very late ST and in second-generation DES, which most likely represent the growing population with previous second-generation stents.

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Comparison of Short- and Long-Term Cardiac Mortality in Early Versus Late Stent Thrombosis (from Pooled PROTECT Trials)

Cited by 41 publications

References 23 publications

Incidence, predictors, and clinical outcomes of early stent thrombosis in acute myocardial infarction patients treated with primary percutaneous coronary angioplasty (insights from the University of Ottawa Heart Institute STEMI registry)

Incidence, predictors, and clinical outcomes of early stent thrombosis in acute myocardial infarction patients treated with primary percutaneous coronary angioplasty (insights from the University of Ottawa Heart Institute STEMI registry)

ST-segment Elevation Myocardial Infarction Resulting from Stent Thrombosis in Contemporary Real-World Practice

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