Comparison of seven different anesthesia protocols for nicotine pharmacologic magnetic resonance imaging in rat

Paasonen, Jaakko; Salo, Raimo A.; Shatillo, Artem; Forsberg, Markus; Närväinen, Johanna; Huttunen, Jari T.; Gröhn, Olli

doi:10.1016/j.euroneuro.2015.12.034

Cited by 56 publications

(65 citation statements)

References 45 publications

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“…injections 15 minutes apart (1.25–1.50 g/kg) while gradually lowering the isoflurane level, reaching 0% after the last injection. We chose to use urethane as it enables a strong blood-oxygen-level dependent (BOLD) response [12, 13] and it is known to maintain near normal electrophysiology and blood gases in spontaneously breathing animals [14, 15]. …”

Section: Methodsmentioning

confidence: 99%

Orientation selective deep brain stimulation

et al. 2017

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Objective Target selectivity of deep brain stimulation (DBS) therapy is critical, as the precise locus and pattern of the stimulation dictates the degree to which desired treatment responses are achieved and adverse side effects are avoided. There is a clear clinical need to improve DBS technology beyond currently available stimulation steering and shaping approaches. We introduce orientation selective neural stimulation as a concept to increase the specificity of target selection in DBS. Approach This concept, which involves orienting the electric field along an axonal pathway, was tested in the corpus callosum of the rat brain by freely controlling the direction of the electric field on a plane using a three-electrode bundle, and monitoring the response of the neurons using functional magnetic resonance imaging (fMRI). Computational models were developed to further analyze axonal excitability for varied electric field orientation. Main results Our results demonstrated that the strongest fMRI response was observed when the electric field was oriented parallel to the axons, while almost no response was detected with the perpendicular orientation of the electric field relative to the primary fiber tract. These results were confirmed by computational models of the experimental paradigm quantifying the activation of radially distributed axons while varying the primary direction of the electric field. Significance The described strategies identify a new course for selective neuromodulation paradigms in DBS based on axonal fiber orientation.

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Section: Methodsmentioning

confidence: 99%

Orientation selective deep brain stimulation

et al. 2017

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“…injections 15 minutes apart (1.25–1.50 g/kg) while gradually lowering the isoflurane level, reaching 0% after the last injection. Urethane anesthesia enables a strong BOLD response and it is known to maintain near normal electrophysiology and blood gases in spontaneously breathing animals (Huttunen et al, 2008; Paasonen et al, 2016). …”

Section: Methodsmentioning

confidence: 99%

MB-SWIFT functional MRI during deep brain stimulation in rats

et al. 2017

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Recently introduced 3D radial MRI pulse sequence entitled Multi-Band SWeep Imaging with Fourier Transformation (MB-SWIFT) having inherently zero acquisition delay was used to obtain functional MRI (fMRI) contrast in rat’s brain at 9.4 Tesla during deep brain stimulation (DBS). The results demonstrate that MB-SWIFT allows images free of susceptibility artefacts, and provides an excellent fMRI activation contrast in the brain. Flip angle dependence of the MB-SWIFT fMRI signal and elimination of the fMRI contrast while using saturation bands, indicate a blood flow origin of the observed fMRI contrast. MB-SWIFT fMRI modality permits activation studies in the close proximity to the implanted lead, which is not possible to achieve with conventionally used gradient echo and spin echo - echo planar imaging fMRI techniques. We conclude that MB-SWIFT fMRI is a powerful imaging modality for investigations of functional responses during DBS.

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“…Performing MRI of animals typically requires anesthesia to obtain adequate immobilization and to reduce stress or pain in relation to diseases and/or invasive procedures . A multitude of different anesthetics and anesthesia procedures are used throughout the literature, potentially affecting the acquired bio‐chemical information and thus imposing constraints on the comparability of studies performed under different circumstances.…”

Section: Introductionmentioning

confidence: 99%

Effects of anesthesia on renal function and metabolism in rats assessed by hyperpolarized MRI

Mariager

Lindhardt

et al. 2018

Magnetic Resonance in Med

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This study demonstrates different renal metabolic and hemodynamic changes under 3 different anesthetics, using hyperpolarized MR in rats. Inactin and sevoflurane were found to affect the renal hemodynamic and metabolic status to a lesser degree than FFM. Sevoflurane anesthesia is particularly easy to induce and maintain during the whole anesthesia procedure, and as such, represents a good alternative to inaction, although it alters the blood glucose level.

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Comparison of seven different anesthesia protocols for nicotine pharmacologic magnetic resonance imaging in rat

Cited by 56 publications

References 45 publications

Orientation selective deep brain stimulation

Orientation selective deep brain stimulation

MB-SWIFT functional MRI during deep brain stimulation in rats

Effects of anesthesia on renal function and metabolism in rats assessed by hyperpolarized MRI

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