Comparison of serum procollagen III peptide concentrations and PGA index for assessment of hepatic fibrosis

Teare, Julian; Greenfield, S; Thompson, R. P. H.; Simpson, Jennifer; Sherman, David; Bray, G.; Williams, Roger; Peters, Timothy J.; Catterall, A.; Murray-Lyon, J.M.

doi:10.1016/0140-6736(93)91946-j

Cited by 108 publications

(50 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…It has been validated in patients with a variety of chronic liver diseases but particularly in patients with alcoholic liver disease. 24,64 Its accuracy for detecting cirrhosis has been reported to range from 66% to 72%. 24,63 …”

Section: Pga Indexmentioning

confidence: 99%

“…The levels reflect stage of fibrosis in chronic liver disease. 64,87,88 Serum levels of PIIINP reflect the degree of fibrosis in alcoholic liver disease, viral hepatitis, and primary biliary cirrhosis. 64,87,88 Reduction or normalization of PIIINP levels has been observed in those who abstain from alcohol.…”

Section: Piiinpmentioning

confidence: 99%

“…64,87,88 Serum levels of PIIINP reflect the degree of fibrosis in alcoholic liver disease, viral hepatitis, and primary biliary cirrhosis. 64,87,88 Reduction or normalization of PIIINP levels has been observed in those who abstain from alcohol. 89,90 In chronic HCV, PIIINP levels have not been shown to correlate with degree of fibrosis but do correlate with the scores for necrosis.…”

Section: Piiinpmentioning

confidence: 99%

See 2 more Smart Citations

Diagnosis and Quantitation of Fibrosis

2008

View full text Add to dashboard Cite

Section: Pga Indexmentioning

confidence: 99%

Section: Piiinpmentioning

confidence: 99%

Section: Piiinpmentioning

confidence: 99%

See 1 more Smart Citation

Diagnosis and Quantitation of Fibrosis

2008

View full text Add to dashboard Cite

“…Circulating and fluid PIIINP levels have been shown to reflect the fibrotic process occurring during various pathologic conditions, such as acute lung injury (3,4), viral and nonviral liver diseases (5,6), systemic sclerosis (7,8), and vascular remodeling (9). Besides, two previous studies have suggested that serum and urinary PIIINP levels may prove useful in the assessment of renal fibrosis in the native as well as in the transplanted kidney (1,10).…”

mentioning

confidence: 99%

Urinary Procollagen III Aminoterminal Propeptide (PIIINP)

Ghoul¹,

Squalli²,

Servais³

et al. 2010

Clinical Journal of the American Society of Nephrology

View full text Add to dashboard Cite

Background and objectives: Kidney biopsy (KB), to date the only tool for the evaluation of renal fibrosis, carries specific risks, and its relevance is limited by the small size of renal parenchyma assessed. Thus, a noninvasive alternative to KB is required. Collagen type III amino-terminal propeptide (PIIINP) is a degradation product of collagen type III, the increase of which may reflect an ongoing fibrotic process.Design, setting, participants, & measurements: In a prospective study including 199 patients with various stages of chronic kidney disease (CKD), the association between urinary PIIINP/creatinine ratio (UPIIINP/Cr), patients' characteristics, and renal fibrosis was assessed.Results: A total of 118 of the patients had UPIIINP/Cr measured simultaneously with the performance of a KB. In patients, median UPIIINP/Cr was 290 ng/mmol versus 93.7 ng/mmol in controls. In univariate analysis, UPIIINP/Cr was correlated with serum creatinine, estimated GFR, CKD stage, presence of coronary artery disease, and nephropathy type (glomerulonephritis versus other types). In multivariate analysis, only estimated GFR and nephropathy type were correlated with UPIIINP/Cr. UPIIINP/Cr was closely correlated with the extent of interstitial fibrosis in KB assessed using two different methods. Moreover, UPIIINP/Cr >800 ng/mmol had a negative predictive value of 94% to detect patients in whom KB will eventually prove "noninformative" (KB leading neither to a definite diagnosis of nephropathy nor to specific treatment).Conclusions: UPIIINP/Cr is a promising fibro-test for the kidney and may alleviate the need for KB in some patients with CKD. Its predictive value for CKD progression deserves evaluation in prospective studies.

show abstract

“…Показатель рассчитывается на основании протромбинового индекса, уровня гаммаглутамил-транспептидазы (ГГТП) и аполипопротеина А1. Было подтверждено, что у пациентов с хроническим заболеванием печени, а особенно, с АБП точность обнаружения цирроза колеблется в диапазоне от 66 до 72% [17].…”

unclassified

Modern possibilities of diagnosis and quantification of liver fibrosis

Zhuravlyova¹,

Ogneva²

2015

Shidnoevr. z. vnutr. simejnoi med.

View full text Add to dashboard Cite

Comparison of serum procollagen III peptide concentrations and PGA index for assessment of hepatic fibrosis

Cited by 108 publications

References 19 publications

Diagnosis and Quantitation of Fibrosis

Diagnosis and Quantitation of Fibrosis

Urinary Procollagen III Aminoterminal Propeptide (PIIINP)

Modern possibilities of diagnosis and quantification of liver fibrosis

Contact Info

Product

Resources

About