Comparison of Serum Lipoprotein (A) Level in Type 2 Dm and Non-Diabetic Patients With Acute Coronary Syndrome

Abstract

BACKGROUND Coronary artery disease has multifactorial origin including hereditary and acquired risk factors. Newer risk factors which ar e elevated in Indian population include Lp (a), CRP and homocysteine levels. Lipoprotein (a) levels are consistently elevated in Indian population compared to other ethnic groups. The aim of this study is to estimate lipoprotein (a) level in type 2 diabetic and non-diabetic patients with acute coronary syndrome and to correlate its levels with severity of ACS. MATERIALS AND METHODS The present study was a case control study, conducted at MBS Hospital, Kota. The sample size was 50 in each group. 50 patients were type 2 diabetics and 50 patients were non-diabetics. They were categorised as Unstable Angina, NSTEMI and STEMI groups. Lp(a)-C estimation was performed with EDC Helena electrophoretic analyser. Lp(a) was calculated from Lp(a)-C by multiplying with 3. RESULTS Lp(a) level was significantly higher in type 2 diabetics compared with non-diabetic group (15.15 ± 5.3 vs 11.93 ± 5.7, p < 0.02). More number of diabetics had Lp(a)-C level > 10 mg/dL than non-diabetic group. This difference was found to be significant (82% vs 38, p < 0.05). Lp(a)-C levels in all three subgroups of ACS (