Comparison of serum and urinary nephrin levels between normal pregnancies and severe preeclampsia

Son, Ga Hyun; Kwon, Ja Young; Lee, Sanghoo; Park, Jimyeong; Kim, Young‐Jin; Yun, Bohyon; Park, Jung hwa

doi:10.1016/j.ejogrb.2012.10.011

Cited by 35 publications

(30 citation statements)

References 34 publications

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“…Several laboratories have independentlyconfirmed the urinary presence of podocytes, podocyte-specific tryptic peptides, or their respective mRNAs (9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20) (Table 1), following our initial report in 2007 that the urinary excretion of viable podocytes is a highly sensitive and specific marker for preeclampsia (9). These preliminary data also reported a positive correlation between the degree of proteinuria and podocyturia, as determined by podocin staining, further suggesting that these may be mechanistically related and that podocyte loss may contribute to proteinuria in preeclampsia.…”

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confidence: 99%

The Role of the Podocyte in Preeclampsia

Garovic

2014

Clinical Journal of the American Society of Nephrology

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confidence: 99%

The Role of the Podocyte in Preeclampsia

Garovic

2014

Clinical Journal of the American Society of Nephrology

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“…While, a significant decrease in serum nephrin level was recorded in rats pretreated with sodium selenite or taurine prior HgCl 2 . Son et al 73 observed that both serum and urine concentrations of nephrin were significantly higher in the sever preeclamptic group than in the normal pregnancy group. They explained this result as that preeclampsia is associated with renal pathologic changes as glomerular endotheliosis.…”

Section: Discussionmentioning

confidence: 98%

Nephroprotective potential of selenium and taurine against mercuric chloride induced nephropathy in rats

et al. 2014

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Department of Hormones, National Research Centre, Cairo, Egypt AbstractThe study was aimed to estimate whether pre-treatment with sodium selenite or taurine would reverse kidney damage induced by intraperitoneal injection of mercuric chloride in rats. Animals were divided into six groups: (1) control group; (2) sodium selenite group; (3) taurine group; (4) HgCl 2 group; (5) sodium selenite pretreated group; (6) taurine pretreated group. The results demonstrated that HgCl 2 causes significant enhancement in serum malondialdehyde (MDA), creatinine, N-acetyl-beta-D-glucosaminidase (NAG), cystatin C, nephrin and interleukin 6 (IL-6) levels accompanied with significant reduction in serum nitric oxide (NO) level. Pretreatment with sodium selenite or taurine produces significant depletion in MDA, NAG, cystatin C, nephrin and IL-6 levels in concomitant with significant elevation in serum NO level as compared to HgCl 2 group. HgCl 2 induced pathological alterations in the kidney. The ultrastructural investigation of renal cortex of HgCl 2 -administered group revealed that the glomerular basement membrane is uniform, the fenestrations of endothelial cells are swollen, and the secondary foot processes appear also swollen even fused at some points. The proximal convoluted tubules showed apical short and few microvilli, while, some tubular cells showed relatively normal microvilli. In contrast, sodium selenite or taurine pretreatment could significantly reduce the pathological alterations in the kidney caused by HgCl 2 intoxication. The current results suggested that selenium and taurine possess nephroprotective efficacy due to their antioxidative capacity and anti-inflammatory activity.

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“…Another 10 blood experimental biomarkers (AT-1AA [31], calcyclin, copeptin [34], galectin-1 [36], Gas6 [37], HIF-1aOH [38], IGFALS [41], mammalian HtrA3 [45], NT-proBNP [47], and PTX3 [49]), and four urine ones (C5b-9 [33], nephrin [46], iodine [42], and prolactin [52]) had limited clinical evaluation information, which impeded the evaluation of their performance for the diagnosis of PE. No clinical data were found for the remaining nine blood markers, which consisted of adipsin, α enolase, ADMA, Ba, 2,3-BPGM, Fetal DNA, marinobufagenin, plasma UA [51], and soluble CD117.…”

Section: Resultsmentioning

confidence: 99%

Towards biomarker-based tests that can facilitate decisions about prevention and management of preeclampsia in low-resource settings

Acestor

Goett

Lee

et al. 2016

Clinical Chemistry and Laboratory Medicine (CCLM)

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Abstract:In recent years, an increasing amount of literature is emerging on candidate urine and blood-based biomarkers associated with incidence and severity of preeclampsia (PE) in pregnant women. While enthusiasm on the usefulness of several of these markers in predicting PE is evolving, essentially all work so far has focused on the needs of high-resource settings and high-income countries, resulting primarily in multi-parameter laboratory assays based on proteomic and metabolomics analysis techniques. These highly complex methods, however, require laboratory capabilities that are rarely available or affordable in low-resource settings (LRS). The importance of quantifying maternal and perinatal risks and identifying which pregnancies can be safely prolonged is also much greater in LRS, where intensive care facilities that can rapidly respond to PE-related health threats for women and infants are limited. For these reasons, simple, low cost, sensitive, and specific point-of-care (POC) tests are needed that can be performed by antenatal health care providers in LRS and that can facilitate decisions about detection and management of PE. Our study aims to provide a comprehensive systematic review of current and emerging blood and urine biomarkers for PE, not only on the basis of their clinical performance, but also of their suitability to be used in LRS-compatible test formats, such as lateral flow and other variants of POC rapid assays.

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Comparison of serum and urinary nephrin levels between normal pregnancies and severe preeclampsia

Cited by 35 publications

References 34 publications

The Role of the Podocyte in Preeclampsia

The Role of the Podocyte in Preeclampsia

Nephroprotective potential of selenium and taurine against mercuric chloride induced nephropathy in rats

Towards biomarker-based tests that can facilitate decisions about prevention and management of preeclampsia in low-resource settings

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