Comparison of serum 1,25-dihydroxycholecalciferol concentrations in rheumatoid arthritis and osteoarthrosis.

Bird, H. A.; Wright, V.; Hennes, U.; Theiss, Erich A.

doi:10.1136/ard.41.3.257

Cited by 26 publications

(5 citation statements)

References 3 publications

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“…Studies of vitamin D levels comparing populations with and without existent autoimmune diseases have been conducted around the world and with somewhat conflicting results. In RA, for example, two past studies revealed lower levels of 25(OH)D in RA patients than in healthy matched controls(114, 115), but five studies did not find such a difference (116-119, 120 ). Patel and colleagues found a strong inverse association between baseline levels of serum 25(OH)D in patients with newly diagnosed early inflammatory polyarthritis (45%of whom were classified as having RA at 1 year) and baseline disease activity, as assessed by tender joint counts, RA disease activity scores (DAS28) and health assessment questionnaires (HAQ) scores(121).…”

Section: Resultsmentioning

confidence: 98%

Does Vitamin D Affect Risk of Developing Autoimmune Disease?: A Systematic Review

Kriegel¹,

Manson²,

Costenbader³

2011

Seminars in Arthritis and Rheumatism

162

113

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Objectives We evaluated the epidemiologic evidence that vitamin D may be related to human autoimmune disease risk. Methods PubMed limited to English from inception through April 2010 was searched using keywords: “vitamin D”, “autoimmune” and autoimmune disease names. We summarized in vitro, animal, and genetic association studies of vitamin D in autoimmune disease pathogenesis. We sorted studies by design and disease and performed a systematic review of: a) cross-sectional data concerning vitamin D level and autoimmune disease; b) interventional data on vitamin D supplementation in autoimmune diseases and c) prospective data linking vitamin D level or intake to autoimmune disease risk. Results Vitamin D has effects on innate and acquired immune systems and vitamin D receptor polymorphisms have been associated with various autoimmune diseases. In experimental animal models, vitamin D supplementation can prevent or forestall autoimmune disease. We identified 76 studies in which vitamin D levels were studied in autoimmune disease patients, particularly with active disease, and compared to controls. Nineteen observational or interventional studies assessed the effect of vitamin D supplementation as therapy for various autoimmune diseases (excluding psoriasis and vitiligo) with a range of study approaches and results. The few prospective human studies performed conflict as to whether vitamin D level or intake is associated with autoimmune disease risk. No interventional trials have investigated whether vitamin D affects human autoimmune disease risk. Conclusions Cross-sectional data point to a potential role of vitamin D in autoimmune disease prevention, but prospective interventional evidence in humans is still lacking.

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Section: Resultsmentioning

confidence: 98%

Does Vitamin D Affect Risk of Developing Autoimmune Disease?: A Systematic Review

Kriegel¹,

Manson²,

Costenbader³

2011

Seminars in Arthritis and Rheumatism

162

113

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“…The principal action of 1,25(OH),D is to increase intestinal calcium absorption. Generally, the serum concentrations of 1 ,25(OH)2D are reported to be normal (6,11,17,19) in R A patients. In contrast to previous studies low serum 1,25 (OH),D concentrations both in the summer and winter seasons are reported in this study.…”

Section: Discussionmentioning

confidence: 94%

Low Serum Vitamin D Metabolites in Women with Rheumatoid Arthritis

Kröger

Penttilä²,

Alhava

1993

Scandinavian Journal of Rheumatology

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The etiology of osteoporosis associated with rheumatoid arthritis (RA) is unknown. We studied the calcium and vitamin D metabolism in 143 women with RA (mean age 50.7 years). Albumin corrected serum calcium was normal. Serum alkaline phosphatase was increased in 29 percent of cases. Serum vitamin D levels were frequently very low. In 16 percent of the RA patients serum 25(OH)D concentration was below 12.5 nmol/L, which is arbitrarily considered as the limit of vitamin D deficiency osteomalacia. In the winter season 73 percent of the patients had serum 1,25(OH)2D levels below the seasonally adjusted normal range. The lowest values were found in patients with high disease activity. We suggest that there is a disturbance in vitamin D metabolism in RA. This might play a role in osteoporosis associated with RA.

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“…The total amount of 25 hydroxyvitamin D is reported to be normal in all (12,14,17,18) but one study (13); the serum concentrations of 1,25 dihydroxyvitamin D are reported to be normal (12,13,18) or slightly increased (17). An increase was found in patients with a short disease duration, who also had an increased fractional calcium absorption (21).…”

Section: Generalised Bone Involvementmentioning

confidence: 85%

Bone metabolism in patients with rheumatoid arthritis

Bijlsma¹

1988

Clin Rheumatol

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Bone metabolism in patients with rheumatoid arthritis is reviewed. Two different entities are recognised: 1) a localised periarticular bone loss, due to inflammatory processes and 2) a generalised increased bone turnover, ultimately leading to a loss of axial bone mass. The mechanism of this loss of axial bone is not completely understood; probably immobilisation is the most important factor. The influence of certain drugs is discussed.

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Comparison of serum 1,25-dihydroxycholecalciferol concentrations in rheumatoid arthritis and osteoarthrosis.

Cited by 26 publications

References 3 publications

Does Vitamin D Affect Risk of Developing Autoimmune Disease?: A Systematic Review

Does Vitamin D Affect Risk of Developing Autoimmune Disease?: A Systematic Review

Low Serum Vitamin D Metabolites in Women with Rheumatoid Arthritis

Bone metabolism in patients with rheumatoid arthritis

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