Comparison of selective head cooling versus whole‐body cooling

Çelik, Yalçın; Atıcı, Aytuğ; Gülaşı, Selvi; Okuyaz, Çetin; Makharoblidze, Khatuna; Sungur, Mehmet Alı

doi:10.1111/ped.12747

Cited by 22 publications

(15 citation statements)

References 33 publications

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“…A research study comparing selective head cooling therapy with whole body cooling therapy in newborns with hypoxic ischemic encephalopathy uncovered no difference between the two methods in terms of adverse effects and short-term results (Atici et al, 2015). Other research studies have also reached similar conclusion about hypoxic ischemic encephalopathy (Sarkar et al, 2009a,b; Celik et al, 2016). However, it was reported that local hypothermia is better than general hypothermia with a significantly lower rate of severe cortex lesions (Rutherford et al, 2005).…”

Section: Hypothermia Induction Methodssupporting

confidence: 71%

Neuroprotection by Therapeutic Hypothermia

et al. 2019

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Hypothermia therapy is an old and important method of neuroprotection. Until now, many neurological diseases such as stroke, traumatic brain injury, intracranial pressure elevation, subarachnoid hemorrhage, spinal cord injury, hepatic encephalopathy, and neonatal peripartum encephalopathy have proven to be suppressed by therapeutic hypothermia. Beneficial effects of therapeutic hypothermia have also been discovered, and progress has been made toward improving the benefits of therapeutic hypothermia further through combination with other neuroprotective treatments and by probing the mechanism of hypothermia neuroprotection. In this review, we compare different hypothermia induction methods and provide a summarized account of the synergistic effect of hypothermia therapy with other neuroprotective treatments, along with an overview of hypothermia neuroprotection mechanisms and cold/hypothermia-induced proteins.

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Section: Hypothermia Induction Methodssupporting

confidence: 71%

Neuroprotection by Therapeutic Hypothermia

et al. 2019

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“…Two methods of cooling have been used in clinical trialsselective head cooling and whole body cooling. One small single-centre trial compared both methods of cooling and found no difference in outcomes at 12 months of age in infants enrolled (29). Larger clinical trials found similar effects on death and disability outcomes when either method was compared with placebo (30).…”

Section: Which Methods Should Be Used To Provide Hypothermia?mentioning

confidence: 99%

Hypothermia for newborns with hypoxic-ischemic encephalopathy

Lemyre

Chau

2018

Paediatrics &Amp; Child Health

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“…The same team of researchers conducted a small randomized study (17 in SHC vs. 12 in WBC group) and recorded the death rate at 41 vs. 33% and survivors without disability of 18 vs. 33% in the SHC and WBC respectively [32]. However, the differences did not reach the level of statistical significance, which may be ascribed to a limited study group.…”

Section: Discussionmentioning

confidence: 99%

Therapeutic hypothermia in asphyxiated newborns: selective head cooling vs. whole body cooling — comparison of short term outcomes

et al. 2019

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Objectives: Therapeutic hypothermia TH became broadly used in the management of the asphyxiated newborns. Although two cooling methods are used, so far the superiority of none of them has been established. The purpose of the study is to compare two cooling methods: selective head cooling (SHC) and whole body cooling (WBC) Material and methods:We conducted a prospective observational study in newborns with HIE. The patients received one of methods: SHC or WBC. The eligibility criteria were similar to previous studies. Stability of cardio-respiratory parameters and short term outcomes were analyzed.Results: 78 neonates with hypoxic-ischemic encephalopathy due to perinatal asphyxia were involved in this study. The SHC group consisted of 51 newborns, the WBC group consisted of 27 patients. Both study groups had similar baseline characteristics and condition at birth. There were no significant differences in hospital course, neurological status and adverse effects associated with cooling procedure between groups. Analyzing the rate of thrombocytopenia and the number of transfusions of blood components no statistically significant differences were found between the groups. Conclusions:Results of our study indicate that two compared methods of TH despite varied target core temperature ranges do not differ significantly according to clinical course and risk of adverse events. Further observations are conducted and we look forward to the results of the long neurodevelopmental care.

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Comparison of selective head cooling versus whole‐body cooling

Abstract: There were no significant differences in adverse effects, 12 month neuromotor development, or mortality rate between SHC and WBC in newborns with HIE, born after >35 weeks of gestation.

Cited by 22 publications

References 33 publications

Neuroprotection by Therapeutic Hypothermia

Neuroprotection by Therapeutic Hypothermia

Hypothermia for newborns with hypoxic-ischemic encephalopathy

Therapeutic hypothermia in asphyxiated newborns: selective head cooling vs. whole body cooling — comparison of short term outcomes

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