Comparison of sedation scores and propofol induction doses in dogs after intramuscular administration of dexmedetomidine alone or in combination with methadone, midazolam, or methadone plus midazolam

Canfrán, Susana; Bustamante, Rocío; González, Pablo; Cediel, Rafael; Re, Michela; Segura, Ignacio A. Gómez de

doi:10.1016/j.tvjl.2016.01.015

Cited by 30 publications

(33 citation statements)

References 19 publications

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“…Alone, in healthy dogs it provides minimal sedation (Court & Greenblatt 1992). The combination has been described in a few experimental studies in dogs that suggest improved sedation and a decrease in propofol requirements compared to medetomidine alone (Hayashi et al 1994;Canfrán et al 2016).…”

Section: Introductionmentioning

confidence: 99%

Use of midazolam in combination with medetomidine for premedication in healthy dogs

Chevallier

Slingsby

Murrell

2019

Veterinary Anaesthesia and Analgesia

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Objective To assess the sedative effects, propofol sparing properties and impact on quality of induction and intubation of intravenous (IV) medetomidine and midazolam administered consecutively at different doses compared to medetomidine alone in healthy dogs for premedication. Study design Prospective, randomized, blinded, clinical study. Animals A total of 40 adult healthy client owned dogs, weighing 18 ± 7 kg (mean ± standard deviation). Methods Dogs were assigned to four groups: medetomidine 15 µg kg-1 (positive control group), medetomidine 10 µg kg-1 & midazolam 0.2 mg kg-1 , medetomidine 5 µg kg-1 & midazolam 0.3 mg kg-1 and medetomidine 5 µg kg-1 & midazolam 0.2 µg kg-1. The same clinician assessed sedation after administration at T2.5 minutes and T5 minutes using a composite simple descriptive sedation scale (CSDS) between 0 and 15 (0= no sedation;15=profound sedation). The dose of propofol for induction, quality of induction, ease of intubation and any adverse events were recorded. Results There was no significant difference in sedation scores between treatment groups at T2.5 minutes or T5 minutes (p=0.82 and p=0.63 respectively). Administration of midazolam in combination with medetomidine resulted in 71% of dogs displaying paradoxical behaviours (p<0.0001) such as agitation, excitation, restlessness, aggression and vocalization which was different from pre-sedation. Propofol requirement was not different between groups. Induction and tracheal intubation quality was smooth in all groups. Conclusion In healthy dogs, at the doses studied, the combination of medetomidinemidazolam administered IV for premedication provided moderate sedation but was associated with a high incidence of paradoxical behaviours. This drug combination IV is not recommended for premedication in healthy dogs.

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Section: Introductionmentioning

confidence: 99%

Use of midazolam in combination with medetomidine for premedication in healthy dogs

Chevallier

Slingsby

Murrell

2019

Veterinary Anaesthesia and Analgesia

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“…This effect may be attributed to the wide action of methadone on the nociceptive pathway, giving it superior antinociceptive potency and duration (Gourlay et al 1982;Sarrau et al, 2007), thus leading to a more effective block of central sensitization (Dyson, 2008;Gottschalk et al, 2011). The propofol sparring effect observed in the MET group (20%) has been described for other opioids (Short and Bufalari 1999;Covey-Crump and Murison 2008;Kaur et al, 2013) and for the methadone/ dexmedetomidine association (Canfrán et al, 2016) and can be attributed to the strong sedative effect of methadone on dogs (Monteiro et al, 2009), which was not observed when tramadol was used. However, the sedation in these animals was not evaluated and is a limiting factor in the present study.…”

Section: Discussionmentioning

confidence: 88%

Pre-emptive methadone or tramadol analgesia for mastectomy and ovariohysterectomy in bitches

Uscategui

Tiosso

Moro

et al. 2017

Rev Colomb Cienc Pecu

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Analgesia preventiva con tramadol o metadona para mastectomia y ovario histerectomía en perrasAnalgesia preventiva com tramadol ou metadona para mastectomia e ováriohisterectomia em cadelas Abstract Background: mastectomy and ovariohysterectomy (OVH) in bitches are critical surgeries and pain control can be challenging. Objective: to evaluate the efficacy of pre-emptive analgesia with methadone (MET) or tramadol (TRA) in postoperative pain intensity, cardiorespiratory effects, and anaesthetic/analgesic consumption in female dogs undergoing mastectomy and OVH. Methods: a prospective randomized blind clinical trial was used to evaluate 48 bitches of various breeds, aged 10 ± 3.7 years, weighing 16 ± 12 Kg, and with multiple mammary tumours. The animals were distributed in two groups: TRA group received 5 mg/Kg tramadol and MET group 0.5 mg/Kg methadone intramuscularly, 10 min prior to anaesthesia induction with propofol followed by maintenance with isoflurane. Heart (HR) and respiratory (RR) rates, mean arterial pressure (MAP), propofol induction dose (PID), oxyhemoglobin saturation (SpO 2 ), end-tidal isoflurane concentration (EtISO), and carbon dioxide pressure (EtCO 2 ) were measured during the intra-operative period. Post-operative pain was evaluated for 12 h and rated according to the Melbourne scale. Rescue analgesia (0.5 mg/Kg methadone, 2 mg/Kg lidocaine, or 0.01 mg/Kg/min ketamine IV) was given when necessary and post-operative analgesic consumption recorded. Statistical tests were used to compare treatments. Results: rescue analgesia requirements, pain score, PID and analgesic consumption were significantly lower (p<0.05) in MET group. The HR was higher in TRA group, while EtCO 2 and MAP were higher in MET group (p<0.05). Conclusion: methadone was more effective than tramadol in pre-emptive analgesia but not completely adequate on controlling pain in bitches subjected to

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“…A administração de midazolan concomitante à cetamina minimiza o efeito estimulante cardiovascular (CANFRAN, et al,2016), e os fenotiazínicos e opióides promovem bradicardia atenuando a ação do anestésico dissociativo (MIZIARA et al, 2016). Neste estudo, com intenção de minimizar os efeitos da cetamina, no GA (P1) foram administrados na MPA acepromazina e fentanil, porém, ainda percebeu-se presença de elevação no ritmo e frequência cardíaca constante, mas, sem significância durante todos os tempos analisados de transoperatório com o efeito de manipulação abdominal.…”

Section: Resultsunclassified

Parâmetros Eletrocardiográficos De Cães Submetidos À Anestesia Dissociativa E Total Intravenosa Em Procedimento Acadêmico De Ovariossalpingohisterectomia

Zanella¹,

Vieira²,

Locatelli³

et al. 2016

Encicl. Biosf.

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RESUMO Objetivou-se avaliar os efeitos eletrocardiográficos durante a manipulação cirúrgica de OSH em cadelas submetidas a dois protocolos anestésicos em ambiente acadêmico. Em sete cadelas (GA/P1) a medicação pré-anestésica utilizada foi acepromazina (0,05 mg.kg-1) e fentanil (0,02 mg.kg-1), seguido da indução e manutenção anestésica com midazolan (0,05 mg.kg-1) e cetamina (6mg.kg-1). Outras sete cadelas (GB/P2) receberam atropina (0,044 mg.kg-1) e xilazina (0,5 mg.kg-1) e associação de diazepan (1 mg.kg-1) e propofol (5 mg.kg-1) respectivamente. Os seguintes parâmetros foram monitorados pelo eletrocardiograma (ECG): frequência cardíaca (FC) e ritmo, polaridade da onda T, polaridade do complexo QRS e nivelamento do segmento ST. Houve diferença significativa da FC sem alterações eletrocardiográficas (P>0,05) entre os grupos. Não se observou elevação da polaridade da onda T, aumento de amplitude do complexo QRS nem desnivelamento do segmento ST. A manipulação cirúrgica e os protocolos anestésicos não influenciaram no traçado do ECG (P>0,05). PALAVRAS-CHAVE: ambiente acadêmico, eletrocardiograma, protocolo anestésico.

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Comparison of sedation scores and propofol induction doses in dogs after intramuscular administration of dexmedetomidine alone or in combination with methadone, midazolam, or methadone plus midazolam

Cited by 30 publications

References 19 publications

Use of midazolam in combination with medetomidine for premedication in healthy dogs

Use of midazolam in combination with medetomidine for premedication in healthy dogs

Pre-emptive methadone or tramadol analgesia for mastectomy and ovariohysterectomy in bitches

Parâmetros Eletrocardiográficos De Cães Submetidos À Anestesia Dissociativa E Total Intravenosa Em Procedimento Acadêmico De Ovariossalpingohisterectomia

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