Comparison of sedation in dogs: methadone or butorphanol in combination with dexmedetomidine intravenously

Trimble, Toby; Bhalla, Rebecca J.; Leece, Elizabeth A

doi:10.1016/j.vaa.2018.03.008

Cited by 8 publications

(7 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Additionally, methadone acts as a noncompetitive antagonist of glutamate binding to n‐Methyl‐D‐aspartate (NMDA) receptors (Gorman, Elliott, & Inturrisi, ) and can inhibit serotonin and norepinephrine reuptake and promote the blockage of nicotinic receptors, all of which contribute to its analgesic activity (Codd, Shank, Schupsky, & Raffa, ). Methadone is a potent analgesic that causes dose‐dependent sedation in dogs; moreover, it can be as effective as morphine but with fewer side effects, such as nausea, vomiting and dysphoria (Monteiro et al, ; Trimble, Bhalla, & Leece, ).…”

Section: Introductionmentioning

confidence: 99%

Clinical pharmacokinetics of a dexmedetomidine–methadone combination in dogs undergoing routine anaesthesia after buccal or intramuscular administration

Cesare

Gioeni

Ravasio

et al. 2019

Vet Pharm & Therapeutics

View full text Add to dashboard Cite

This study aimed to define the pharmacokinetic profiles of dexmedetomidine and methadone administered simultaneously in dogs by either an oral transmucosal route or intramuscular route and to determine the bioavailability of the oral transmucosal administration relative to the intramuscular one of both drugs, so as the applicability of this administration route in dogs. Twelve client‐owned dogs, scheduled for diagnostic procedures, were treated with a combination of dexmedetomidine hydrochloride (10 μg/kg) and methadone hydrochloride (0.4 mg/kg) through an oral transmucosal route or intramuscularly. Oral transmucosal administration caused ptyalism in most subjects, and intramuscular administration caused transient peripheral vasoconstriction. The results showed reduced and delayed absorption of both dexmedetomidine and methadone when administered through an oral transmucosal route, with median (range) Cmax values of 0.82 (0.42–1.49) ng/ml and 13.22 (2.80–52.30) ng/ml, respectively. The relative bioavailability was low: 16.34% (dexmedetomidine) and 15.5% (methadone). Intramuscular administration resulted in a more efficient absorption profile, with AUC and Cmax values for both drugs approximately 10 times higher. Dexmedetomidine and methadone administered simultaneously by an oral transmucosal route using injectable formulations were not well absorbed through the oral mucosa. Nevertheless, additional studies on these drugs combination using alternative administration routes are recommended.

show abstract

Section: Introductionmentioning

confidence: 99%

Clinical pharmacokinetics of a dexmedetomidine–methadone combination in dogs undergoing routine anaesthesia after buccal or intramuscular administration

Cesare

Gioeni

Ravasio

et al. 2019

Vet Pharm & Therapeutics

View full text Add to dashboard Cite

show abstract

“…Congdon et al (2011) [5] also observed potent sedation enabling minor clinical procedures in dogs with intramuscular administration of dexmedetomidine @10 mcg/kg. Similarly, Trimble et al (2018) [32] also reported high sedation with butorphanol and dexmedetomidine in dog. The induction dose (mg/kg) of propofol in Group A was 0.68± 0.06 and ketamine in Group B was 2.63±0.26.…”

Section: Resultsmentioning

confidence: 80%

Propofol and ketamine CRI in dexmedetomidine and butorphanol premedicated dogs

Bayan¹,

Sarma²,

Rao³

et al. 2020

Pharma Innovation

View full text Add to dashboard Cite

The study was carried out to evaluate propofol and ketamine CRI in dexmedetomidine and butorphanol pre-medicated dogs undergoing elective ovariohysterectomy. Animals were randomly divided into two Groups (A and B) comprising six animals in each. All the animals were administered glycopyrrolate @ 0.01 mg/kg IM. Fifteen minutes later dexmedetomidine 5µg/kg IV and butorphanol 0.1mg/kg IV and two minutes later induction and maintenance of anaesthesia was done with propofol in Group A and ketamine in Group B. The mean induction times (Sec) in Group A and B were recorded as 34.67 ± 2.12 and 36.67±1.63, respectively. The induction doses of propofol and ketamine were recorded as 0.68± 0.06 and 2.63±0.26 mg/kg, respectively. The recovery time were recorded as 10.25±0.44 and 14.83±1.26 min in Group A and B, respectively. The maintenance dose of propofol and ketamine for CRI were recorded as 0.24±0.01 and 0.013±0.60 mg/kg/min, respectively in Group A and B. Quality of anaesthesia was excellent in both the group and the clinical parameters remained with the physiological limit.

show abstract

“…There are differences in the sedative effects between opioids, with butorphanol producing greater sedation than methadone in combination with dexmedetomidine in healthy dogs (Trimble and others 2018), and methadone producing greater sedation than butorphanol in dogs sedated with acepromazine (Monteiro and others 2009).…”

Section: Clinical Pharmacology Of Commonly Used Premedicant Agentsmentioning

confidence: 99%

Premedicants in cats and dogs: which one should you choose and when?

Murrell¹

2022

In Practice

View full text Add to dashboard Cite

Background: Premedication is an integral part of any anaesthetic protocol and the drugs chosen for premedication will determine the characteristics of the ensuing anaesthetic. Choosing appropriate premedicant drugs for the individual patient is vital to ensure a smooth and stress‐free anaesthetic. Normally, a balanced premedication protocol involving both a sedative and a hypnotic is advocated. This allows the two key aims of premedication – sedation and analgesia – to be met. Synergistic sedation between most sedatives and opioids also means that combining these drugs allows lower doses of each individual agent to be used.Aim of the article: This article discusses how it is important to know the clinical pharmacology of the different drugs used for premedication in order to make a rational decision about premedicant selection. One way to think about premedicant selection is based on the American Society of Anaesthesiologists (ASA) physical status classification system of the cat or dog, whereby the health status of the individual is used to inform about suitable premedication protocols.

show abstract

Comparison of sedation in dogs: methadone or butorphanol in combination with dexmedetomidine intravenously

Cited by 8 publications

References 19 publications

Clinical pharmacokinetics of a dexmedetomidine–methadone combination in dogs undergoing routine anaesthesia after buccal or intramuscular administration

Clinical pharmacokinetics of a dexmedetomidine–methadone combination in dogs undergoing routine anaesthesia after buccal or intramuscular administration

Propofol and ketamine CRI in dexmedetomidine and butorphanol premedicated dogs

Premedicants in cats and dogs: which one should you choose and when?

Contact Info

Product

Resources

About