Comparison of Seal Oil to Tuna Oil on Plasma Lipid Levels and Blood Pressure in Hypertriglyceridaemic Subjects

Abstract

Comparison of seal oil to tuna oil on plasma lipid levels and blood pressure in hypertriglyceridaemic subjects AbstractAs meat is a rich source of the omega-3 fatty acid docosapentaenoic acid (DPA) and Australians consume six times more meat than fish, investigation of the potential health benefit of DPA is warranted. The aims were to compare the effects of seal oil supplementation with fish oil, on measures of plasma lipids and blood pressure in hypertriglyceridaemic subjects. Forty-eight volunteers were recruited from the Wollongong community and were randomly allocated to one of three groups either receiving 1 g/day of long-chain omega-3 polyunsaturated fatty acids (LC n-3 PUFA) using one of three oils: seal oil capsules (340 mg eicosapentaenoic acid (EPA), 230 mg DPA, 450 mg DHA), fish oil capsules (210 mg EPA, 30 mg DPA, 810 mg DHA) or placebo capsules (containing sunola oil) for 6 weeks. Plasma triglycerides remained unchanged in the placebo group, whilst reductions of 7 and 14% (P\0.05) were seen in the fish oil and seal oil groups respectively. Systolic blood pressure improved by 8 and 5 mmHg with seal oil and fish oil respectively (P\0.05). The mean arterial pressure was significantly lower after seal oil supplementation (P\0.005) compared with the placebo group. These results indicate that seal oil is as effective as fish oil in lowering plasma triglycerides and blood pressure. AbstractAs meat is a rich source of the omega-3 fatty acid docosapentaenoic acid (DPA) and Australians consume 6 times more meat than fish, investigation of the potential health benefit of DPA is warranted. The aims were to compare the effects of seal oil supplementation with fish oil, on measures of plasma lipids and blood pressure in hypertriglyceridaemic subjects. Forty-eight volunteers were recruited from the Wollongong community and were randomly allocated to one of three groups receiving 1g/d of long chain omega-3 polyunsaturated fatty acids (LC n-3 PUFA) using one of three oils: seal oil capsules (340mg eicosapentaenoic acid (EPA), 230mg DPA, 450mg DHA), fish oil capsules (210mg EPA, 30mg DPA, 810mg DHA) or placebo capsules (containing sunola oil) for 6 weeks. Plasma triglycerides remained unchanged in the placebo group, whilst reductions of 7% and 14% (p<0.05) were seen in the fish oil and seal oil groups respectively. Systolic blood pressure improved by 8 and 5 mmHg with seal oil and fish oil respectively (p<0.05).The mean arterial pressure was significantly lower after seal oil supplementation (p<0.005) compared with the placebo group. These results indicate that seal oil is as effective as fish oil in lowering plasma triglycerides and blood pressure.

Effects of Seal Oil and Tuna‐Fish Oil on Platelet Parameters and Plasma Lipid Levels in Healthy Subjects

“…Intriguingly, combined seal oil/cod liver oil treatment reportedly decreased subject triacylglycerol levels where pure seal oil or cod liver oil did not [45], even at almost three times the dose of this study. The same modest seal oil dose as we have described, given over 6 weeks, also resulted in a significant decrease in plasma triacylglycerols as well as a significant improvement in blood pressure in hypertriglyceridaemic subjects, without a change in HDL-cholesterol [48]. In the present work, tuna-fish oil supplementation caused a non-significant (P = 0.06) decrease in triacylglycerols.…”

The relevance of serum levels of long chain omega-3 polyunsaturated fatty acids and prostate cancer risk: A Meta-analysis

“…DPA is found in whale meat, seal oil and, to a lesser extent, in marine fatty fish oil together with other long chain n-3 PUFA series (DHA and EPA). 39 Currently, few studies have been conducted to examine the biophysiological effect of DPA because of production costs. Human studies are lacking; most studies are in-vitro or with animal subjects.…”

Effects of feeding steers extruded flaxseed on its own before hay or mixed with hay on animal performance, carcass quality, and meat and hamburger fatty acid composition

“…However, this perception has started to change following recent studies demonstrating cardiovascular and immune health benefits associated with ALA and total n-3 PUFA intake (Fleming & Kris-Etherton, 2014;Molendi-Coste, Legry, & Leclercq, 2011). Furthermore, current LCn-3 PUFA recommendations do not include DPA, the predominant LCn-3 PUFA in beef, despite its similar health profile compared to EPA and DHA (Kaur, Cameron-Smith, Garg, & Sinclair, 2011;Meyer, Lane, & Mann, 2009;Morin, Hiram, Rousseau, Blier, & Fortin, 2014).…”